Conserved Protein Domain Family
TGF_beta_maverick

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cd13755: TGF_beta_maverick 
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins
Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.
Statistics
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PSSM-Id: 381633
Aligned: 14 rows
Threshold Bit Score: 152.079
Created: 16-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens myostatin (5F3H) forms a homodimer.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # # #       # # #      # #####        ## ### ###  ##     ###### ####  # 
NP_524626    598 HQRCCRNQLDVAFk----SIKGFEFILQPKVFDAGYCHGRCPPr-hNPAHHHALLQSLIWq--eDHKRAPRPCCTPSKLE 670 fruit fly
XP_002425332 203 PGKCVRHPWEVDLg----KLKGYEYIVQPRKFDAGLCAGKCTGq-wNLATQHSNLQYLFSn---IDKTIPKPCCAPSKME 274 human body louse
XP_018012949 272 PNRCCKRSMTVRFd----DLPGFDFIAAPKDFDAYYCSGKCPPr-yNPANEHALLQSLINm--qKKKEVPRPCCAPTDLK 344 Hyalella azteca
XP_023327191 250 RGRCCRQSMPVDLr----QLKGFEFIMQPDVFDAYYCKGKCHSr-dLALNDHSLLQYFMHl---RDSKVKKPCCSPRKYE 321 Eurytemora affinis
PRD25766     194 GGKCCRRPLSISF-----ADIGWNWIVQPKEFEAFYCKGRCNDskgHFANTHALMQSILKi---KGHNVSRPCCAPKKLR 265 Nephila clavipes
XP_013792707 398 TTLCCRYSMTISF-----EELKWHWIIRPKQFEAYFCKGRCDPnykNYVSRHARIQNLIRrikdRRKEIPRSCCTPKKMK 472 Atlantic horses...
XP_023219628 199 NYDCCLKKLKVNF-----KEIGWNWIYRPESFDFYYCKGKCRNd-tSILSQNALIRSILRs---RSIKVPRLCCAPKRTG 269 bark scorpion
OXA43914     363 GKTCCRRSLKIKFs----DLGISEVIIEPAEFDAHVCVGRCNAkrvSYSSTHAIFQHILHek-kGKGFVPRPCCAPTKLA 437 Folsomia candida
XP_013773421 302 TKKCCRYKMKVSFqsiplKGTGWEYVIEPKEFDAFVCKGKCNKryrNFLNKHALIQNWMRr--iMKNKIPRLCCTSKKRE 379 Atlantic horses...
XP_002410919 157 TDLCCRHSLKVSF-----AEIGWDWVAEPKEFDAYMCKGRCPNdnrNFNSTHALVQSLMS----ERADVPSPCCAPKSLK 227 black-legged tick
Feature 1           # #               #### #     
NP_524626    671 MLEILHVDenh--sdkLKISTWSDMQVVECAC 700 fruit fly
XP_002425332 275 SLEILYPDedn--pkkLKVSVWNDTKIIECAC 304 human body louse
XP_018012949 345 GLYILHYDhs----gkLKTVLWRDVIVTECGC 372 Hyalella azteca
XP_023327191 322 SRDILHLDemd--strLKVTNWKNIIVRECAC 351 Eurytemora affinis
PRD25766     266 PLELLHYDdkn--ppeLTVTKMKGMIVKECAC 295 Nephila clavipes
XP_013792707 473 PLQVVYLKnk----seVDTKKLRGMIVSQCGC 500 Atlantic horseshoe crab
XP_023219628 270 SLRILHYTdsd--ppkLVVRKLKGMVVKSCGC 299 bark scorpion
OXA43914     438 ELDVIHINsvnpskpkLEVTVLKDAIVSECGC 469 Folsomia candida
XP_013773421 380 PLMVKVIDsh----sqRREGKLDDMIVTECGC 407 Atlantic horseshoe crab
XP_002410919 228 GLSLLYQEgpn--sdlYTVATQQGMVVEECAC 257 black-legged tick

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