5F3H,5E4G,3HH2,5NTU,5NXS


Conserved Protein Domain Family
TGF_beta_GDF8_like
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cd13751: TGF_beta_GDF8_like 
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transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, GDF8 and GDF11, and similar proteins
The family includes GDF8 and GDF11. GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.
Links
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Statistics
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PSSM-Id: 381629
Aligned: 44 rows
Threshold Bit Score: 116.986
Created: 16-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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homodimer
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:5F3H; Homo sapiens myostatin forms a homodimer, contacts at 4A.
  • Structure:5NTU; Homo sapiens pro-myostatin forms a homodimer, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # # #   # #  #      # #####            # ### ###  ##            # ####  #
5F3H_I        12 SRCCRYPLTVDF-EAFGW-DWIIAPKRYKANYCSGECEFvf----lQKYPHTHLVHQANprg-------saGPCCTPTKM 78  human
NP_524626    599 QRCCRNQLDVAFkSIKGF-EFILQPKVFDAGYCHGRCPPrh----nPAHHHALLQSLIWqedh----krapRPCCTPSKL 669 fruit fly
XP_003745948 277 PGCCRYPFEVDF-HQIGW-DWIILPKSYKPNFCRGTCNLev----nLQRQHTIVMSAYMkhypsqakkielSMCCTGVKM 350 western predato...
XP_013781895 321 TRCCRHPLTVDF-AEMKW-DFIIVPLRYQAYYCGGDCPPaf----lPEHLHTVLAQHAAvdks----veplSQCCSASSL 390 Atlantic horses...
XP_018020242 377 TRCCRFPLPVNF-TEHNF-DFIVAPKVYMANFCNGTCDYly----aQQHIHMAMVQKIHsgt------athGPCCGAKEL 444 Hyalella azteca
XP_006814731 276 NYCCRHPLVVNF-TELGYsDWILQPKSYDAYYCSGECRLm-----nPYNPYLDYSILVSth--------giQQCCNPAKM 341 Saccoglossus ko...
XP_006824735 285 EQCCRHPLEVNF-KNDGM-EYVAAPKTYDAYYCTGECNI-------RSNAYSLLLSLRGi-----------EQCCNPLQR 344 Saccoglossus ko...
AEP16386     274 KKCCRYHYFVKF-ADLGM-DWILAPDGYDAYYCSGDCPFmylaeqkSSLYYTFVIARANynnp----maspRPCCTPASL 347 sea walnut
PIK62560     128 ELCCQFPITVTF-DDIGL-NWIVYPKKYTTYQCAGGCPSdd---rlLSLARNDLAVIRSslhrln-sslhpAPCCVPTKL 201 Japanese sea cu...
XP_022087886 327 TTCCRYGQNVSY-SELGWsDWIIQPSHYVSYQCAGDCPTnf----rPATAYSRIKSLMHaidp----ddwnAPCCAPTRF 397 crown-of-thorns...

Feature 1            # #                  #### #     
5F3H_I        79 SPINMLYFNgk-------eqIIYGKIPAMVVDRCGC 107 human
NP_524626    670 EMLEILHVDenh-----sdkLKISTWSDMQVVECAC 700 fruit fly
XP_003745948 351 SSLNIAYSVdg-------knVHQSTLENMIVDECHC 379 western predatory mite
XP_013781895 391 SPITIIYRDeak------nnYLRVLVEDMIVNSCSC 420 Atlantic horseshoe crab
XP_018020242 445 MPLNMLYYDhd-------rkIRFDTINDMIIEKCSC 473 Hyalella azteca
XP_006814731 342 SGIQIIFFTds-------ytIKVDTLHDVVVKKCVC 370 Saccoglossus kowalevskii
XP_006824735 345 EAITIIYYTds-------ytLKKARINDMVVNKCEC 373 Saccoglossus kowalevskii
AEP16386     348 SDLSIMFSSgkvdstgqpldVEIHNLEDMVVDECGC 383 sea walnut
PIK62560     202 SHLDILYTTedd-----pptLEMQELRDFVVEECQC 232 Japanese sea cucumber
XP_022087886 398 GSTAYLFVNgt-------ggLEIAVQRDSVVLECQC 426 crown-of-thorns starfish

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