1S50,1YAE,2I0B,3G3G,3G3H,3G3I,3G3J,3G3K,2XXR,2XXW,2XXU,4BDL,4BDQ,4BDN


Conserved Protein Domain Family
PBP2_iGluR_Kainate_GluR6
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cd13721: PBP2_iGluR_Kainate_GluR6 
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GluR6 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily.
This group contains glutamate receptor domain GluR. These domains are found in the GluR proteins that have been shown to function as L-glutamate activated potassium channels, also known ionotropic glutamate receptors or iGluRs. In addition to two ligand binding core domains, iGluRs typically have a channel-like domain inserted in the middle of the GluR-like domain. Animal iGluRs mediate the ion flux in the synapses of the CNS and can be subdivided into several classes depending on the neurotransmitter specificity and ion conductance properties. Their plant homologs have been shown to function in light signal transduction and calcium homeostasis. The GluR proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Links
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Statistics
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PSSM-Id: 270439
Aligned: 22 rows
Threshold Bit Score: 487.992
Created: 23-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide bindingdimer interface
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:1S50; Rattus norvegicus GluR6 binds glutamate, contacts at 4 A
  • Structure:1YAE; Rattus novegicus GluR6 binds Domoic acid (agonist), contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                  #                     
1S50_A         3 NRSLIVTTILEEPYVLFKksdkplygnDRFEGYCIDLLRELSTILGFTYEIRLVEdgkYGAQDdvnGQWNGMVRELIDHK 82  Norway rat
1YAE_A        12 NRSLIVTTILEEPYVLFKksdkplygnDRFEGYCIDLLRELSTILGFTYEIRLVEdgkYGAQDdvnGQWNGMVRELIDHK 91  Norway rat
3G3G_A         3 NRSLIVTTILEEPYVLFKksdkplygnDRFEGYCIDLLRELSTILGFTYEIRLVEdgkYGAQDdvnGQWNGMVRELIDHK 82  Norway rat
P42260       430 NRSLIVTTILEEPYVLFKksdkplygnDRFEGYCIDLLRELSTILGFTYEIRLVEdgkYGAQDdvnGQWNGMVRELIDHK 509 Norway rat
NP_068775    430 NRSLIVTTILEEPYVLFKksdkplygnDRFEGYCIDLLRELSTILGFTYEIRLVEdgkYGAQDdanGQWNGMVRELIDHK 509 human
CAG03648     129 NKSLRVSTILEEPYVMFKksdkplygnDRFEGYCIDLLRELSSILGFRYELRLVEdgkYGALDestGQWNGMVRELMDHK 208 spotted green p...
Q38PU3       430 NRSLIVTTILEEPYVLFKksdkplygnDRFEGYCIDLLRELSTILGFTYEIRLVEdgkYGAQDdanGQWNGMVRELIDHK 509 crab-eating mac...
P39087       430 NRSLIVTTILEEPYVLFKksdkplygnDRFEGYCIDLLRELSTILGFTYEIRLVEdgkYGAQDdvnGQWNGMVRELIDHK 509 house mouse
BAH14032     381 NRSLIVTTILEEPYVLFKksdkplygnDRFEGYCIDLLRELSTILGFTYEIRLVEdgkYGAQDdanGQWSGMVRELIDHK 460 human
XP_002196529 430 NRSLVVTTILEEPYVMFKksdkplygnDRFEGYCIDLLRELSTILGFSYEIRLVEdgkYGAQEdasGQWNGMVRELIDHK 509 zebra finch

Feature 1              ###    #                                                                  
1S50_A        83 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGT------------------------------------------- 119 Norway rat
1YAE_A        92 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflngg------------------------------ 141 Norway rat
3G3G_A        83 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGT------------------------------------------- 119 Norway rat
P42260       510 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdiwmyillaylgvscvlfviarfspyew 589 Norway rat
NP_068775    510 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdiwmyillaylgvscvlfviarfspyew 589 human
CAG03648     209 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdiwmyillaclgvscvlfviarfspyew 288 spotted green p...
Q38PU3       510 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdiwmyvllaclgvscvlfviarfspyew 589 crab-eating mac...
P39087       510 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdiwmyillaylgvscvlfviarfspyew 589 house mouse
BAH14032     461 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdiwmyillaylgvscvlfviarfspyew 540 human
XP_002196529 510 ADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdiwmyillaylgvscvlfviarfspyew 589 zebra finch

Feature 1                                                                                        
1S50_A       120 -----------------------------------------------------------------------------PID 122 Norway rat
1YAE_A       142 -----------------------------------------------------------------slvprgsermesPID 156 Norway rat
3G3G_A       120 -----------------------------------------------------------------------------PID 122 Norway rat
P42260       590 ynphpcnpdsdvvennftllnsfwfgvgalmqqgselmpkalstrivggiwwfftliiissytanlaafltvermesPID 669 Norway rat
NP_068775    590 ynphpcnpdsdvvennftllnsfwfgvgalmqqgselmpkalstrivggiwwfftliiissytanlaafltvermesPID 669 human
CAG03648     289 ynphpcnpdsdvvennftllnsfwfgvgalmqqgselmpkalstrivggiwwfftliiissytanlaafltvermesPID 368 spotted green p...
Q38PU3       590 ynphpcnpdsdvvennftllnsfwfgvgalmrqgselmpkalstrivggiwwfftliiissytanlaafltvermesPID 669 crab-eating mac...
P39087       590 ynphpcnpdsdvvennftllnsfwfgvgalmqqgselmpkalstrivggiwwfftliiissytanlaafltvermesPID 669 house mouse
BAH14032     541 ynphpcnpdsdvvennftllnsfwfgvgalmrqgselmpkalstrivggiwwfftliiissytanlaafltvermesPID 620 human
XP_002196529 590 ynphpcnpdsdvvennftllnsfwfgvgalmqqgselmpkalstrivggiwwfftliiissytanlaafltvermesPID 669 zebra finch

Feature 1                                                                                        
1S50_A       123 SADDLakqtkIEYGAVEDGATMTFFKKskISTYDKMWAFMSSRrqSVLVKSNEEGIQRVLTSdYAFLMESTTIEFVTQRn 202 Norway rat
1YAE_A       157 SADDLakqtkIEYGAVEDGATMTFFKKskISTYDKMWAFMSSRrqSVLVKSNEEGIQRVLTSdYAFLMESTTIEFVTQRn 236 Norway rat
3G3G_A       123 SADDLakqtkIEYGAVEDGATMTFFKRskISTYDKMWAFMSSRrqSVLVKSNEEGIQRVLTSdYAFLMESTTIEFVTQRn 202 Norway rat
P42260       670 SADDLakqtkIEYGAVEDGATMTFFKKskISTYDKMWAFMSSRrqSVLVKSNEEGIQRVLTSdYAFLMESTTIEFVTQRn 749 Norway rat
NP_068775    670 SADDLakqtkIEYGAVEDGATMTFFKKskISTYDKMWAFMSSRrqSVLVKSNEEGIQRVLTSdYAFLMESTTIEFVTQRn 749 human
CAG03648     369 SADDLakqtkILYGVVEDGATMTFFKKtkISTYDKMWEFMNSRrqSVMVKNVDEGIQRVLTSdYAFLMESTTIEFVTQRn 448 spotted green p...
Q38PU3       670 SADDLakqtkIEYGAVEDGATMTFFKKskISTYDKMWAFMSSRrqSVLVKSNEEGIQRVLTSdYAFLMESTTIEFVTQRn 749 crab-eating mac...
P39087       670 SADDLakqtkIEYGAVEDGATMTFFKKskISTYDKMWAFMSSRrqSVLVKSNEEGIQRVLTSdYAFLMESTTIEFVTQRn 749 house mouse
BAH14032     621 SADDLakqtkIEYGAVEDGATMTFFKKskISTYDKMWAFMSSRrqSVLVKSNEEGIQRVLTSdYAFLMESTTIEFVTQRn 700 human
XP_002196529 670 SADDLakqtkIEYGAVEDGATMTFFKKskISTYDKMWAFMSSRrqSVLVKSNEEGIQRVLTSdYAFLMESTTIEFVTQRn 749 zebra finch

Feature 1                                                           
1S50_A       203 CNLTQIGglIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 253 Norway rat
1YAE_A       237 CNLTQIGglIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 287 Norway rat
3G3G_A       203 CNLTQIGglIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 253 Norway rat
P42260       750 CNLTQIGglIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 800 Norway rat
NP_068775    750 CNLTQIGglIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 800 human
CAG03648     449 CNLTQIGglIDSTAYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 499 spotted green pufferfish
Q38PU3       750 CNLTQIGglIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 800 crab-eating macaque
P39087       750 CNLTQIGglIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 800 house mouse
BAH14032     701 CNLTQIGglIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 751 human
XP_002196529 750 CNLTQIGglIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 800 zebra finch

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