Conserved Protein Domain Family
GluR_Plant
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cd13686: GluR_Plant 
Plant glutamate receptor domain; the type 2 periplasmic binding protein fold
This subfamily contains the glutamate receptor domain GluR. These domains are found in the GluR proteins that have been shown to function as L-glutamate activated potassium channels, also known ionotropic glutamate receptors or iGluRs. In addition to two ligand binding core domains, iGluRs typically have a channel-like domain inserted in the middle of the GluR-like domain. Animal iGluRs mediate the ion flux in the synapses of the CNS and can be subdivided into several classes depending on the neurotransmitter specificity and ion conductance properties. Their plant homologs have been shown to function in light signal transduction and calcium homeostasis. The GluR proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Links
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Statistics
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PSSM-Id: 270404
Aligned: 73 rows
Threshold Bit Score: 227.403
Created: 3-Oct-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O04660        452 KRLQIGVPVNn--TFQQFVKATrdpit-nstiFSGFSIDYFEAVIQai--pYDISYDFIPfq------dgGYDALVYQVY 520  thale cress
Q8LGN1        446 KKLRVLVPAGn--ITPQILEVKtdfkt-gvtaATGYCIDVFETSILp----FNYEVEYIPwpga--inykNYNDLVYTLY 516  thale cress
Q9LV72        440 KKLRVLVTSSn--RFPRLMKVEtdpitheitiVEGFCIEVFQASIAp----FNYEVEYIRwln-----gtNYTKLAYALH 508  thale cress
Q9M8W7        421 KVLRVLVTAGn--KVPHLVSVRpdpet-gvntVSGFCVEVFKTCIAp----FNYELEFIPyr-------gNNDNLAYLLS 486  thale cress
NP_001063236  450 RRLRVAVPGSvnpGYRAIVHLDvdaat-nrttAGGFVVEVFEAAVRll--pYALPVEYVKae------smPYDKLVQMVA 520  Japanese rice
CAN64921      380 KKLRIGVPVId--GFTELVKVDrdlqt-gavsVSGFCIDVFKAAVEnl--pYALTYEFIPfadyngnsagTYSDLVFQVY 454  wine grape
CAN61321      151 KPLKIGIPANg--TFKNFVEVGeaqie-pekkYTGFCIDIFHEVLKileqnYSLPYEFHPvv-------gTYDELVDCVY 220  wine grape
EEC84618      451 RRLRVAVPGSvnpGYRAIVHLDvdaat-nrttAGGFVVEVFEAAVRll--pYALPVEYVKae------smPYDKLVQMVA 521  Indian rice
XP_002316840  363 KPLRIIVPQRt--SFDKFVTFRsge-----krPVGFCVDLFDEVVRrl--nYSIPHVFVHfd-------gQYGDMIEGVY 426  black cottonwood
CBI30648      841 KPLKIGIPANt--TFKNYVKVDvdqie-pekkYTGFCIDIFHEVLKileqnYSLPYEFHPvv-------gTYDELVDCVY 910  wine grape

O04660        521 LGk-----------------------YDAVVADTTISSNRSMYVDFSLPYTPSGVGLVVPVKDsvrrsstiflmpltlal 577  thale cress
Q8LGN1        517 SQkd---------------------kYDAAVGDITITDNRSLYVDFTLPFTDMGLAVVTAKDKsmwiifkpltlslwlti 575  thale cress
Q9LV72        509 SQkd---------------------kYDAAVGDITITSDRSMYVDFTLPYTEMGLGIVAAKERsmwvffqpltpnlwits 567  thale cress
Q9M8W7        487 TQrd---------------------kYDAAVGDITITSNRSLYVDFTLPYTDIGIGILTVKKKsqgmwtffdpfekslwl 545  thale cress
NP_001063236  521 DGa-----------------------FDAAVADMTITAARSSYVDFTLPFMASGIAMVAPLRDvgrggertwvflkplry 577  Japanese rice
CAN64921      455 LQv-----------------------FDAVVGDVTITANRSLYVDFTLPYTELGVGMVVPIEIgkaknmwiflepltvdl 511  wine grape
CAN61321      221 NKt-----------------------YDAVVGDVTILATRSKKVEFTVPYAESGLVIVQVTSEephkawmflkpftrkmw 277  wine grape
EEC84618      522 DGa-----------------------FDAAVADMTITAARSSYVDFTLPFMASGIAMVAPLRDvghggertwvflkplry 578  Indian rice
XP_002316840  427 NKlffqhyfcaechcltlvplvnrktYDAAIGDITILAERTEYVEFTQPYAESGLSMIVPFETedttwifvkpfnlemwm 506  black cottonwood
CBI30648      911 NKt-----------------------YDAVVGDVTILATRSKKVEFTVPYAESGLVIVQVTSEephkawmflktftwetw 967  wine grape

O04660        578 wlisllsffiiglvvwvlehrvnpdfdgpgqyqlstif--wfsfsimvfaprervlsfwarvvviiwyflvlvltqsyta 655  thale cress
Q8LGN1        576 asffiltgaivwlierhdnadfqgscfqqigt-------------llcfgfstlvfahrerlqhnmsrfvvivwifavli 642  thale cress
Q9LV72        568 aaffvltgiivwlieraenkefqgswpqqigv-------------viwfgfstlvyahreklqhnlsrfvvtvwvfavli 634  thale cress
Q9M8W7        546 asgaffvltgivvwlversvnpefqgsw----------------------gqqlsmmlwfgfstivfahreklqkmssrf 603  thale cress
NP_001063236  578 dlwlasaafllltgfavwfvehrgnaefrgppwhqlgtllyfgfstlvfahredlrsnlarlaavvwffvvlilqssyta 657  Japanese rice
CAN64921      512 wlvsgaffiltgcivwfierkindefkgstaqqv---------gmifwysfstlvfsqreklisnlskfvvivwvfavli 582  wine grape
CAN61321      278 vttgallvytmfivwameyqsnnpafrgpwrsqlgtal--wftfsslffahretirsnitrvvivvwlfvvfiltssyta 355  wine grape
EEC84618      579 dlwlasaafllltgfavwfvehrgnaefrgppwhqlgtllyfgfstlvfahrenlrsnlarlaavvwffvvlilqssyta 658  Indian rice
XP_002316840  507 vscaifiytmliiwflehqtnpefrgprkyqfgtafw----ftfsslffaqreklysnftrvvvvawlcvvfiltssyta 582  black cottonwood
CBI30648      968 vvtgalliytmfivwvleyqsnnpafrgpwrsqlgtal--wftfsslffahretirsnitrvvivvwlfvvfvltssyta 1045 wine grape

O04660        656 slasllttqhlhptVTNINSlla-kgESVGYQSSFILGRLRdsgf-seasLVSYGSPEHCDALLSKGqaeggvSAVLMEV 733  thale cress
Q8LGN1        643 ltsnytatltsvmtVQQIRGlks-neNIGFFSASIAANVVNdnptfqgprYKGLKTADDFTNALRNGt----iSFIVDEV 717  thale cress
Q9LV72        635 lvtsytatltsmmtVQQIRFnan-edYVGHLSGSLIANAALtnsslramrLLGLNTSEDYAQALMNKs----vSYIVSEL 709  thale cress
Q9M8W7        604 lvivwvfvvliltsSYSANLtstktiSRMQLNHQMVFGGSTtsm---takLGSINAVEAYAQLLRDGt----lNHVINEI 676  thale cress
NP_001063236  658 sltsmltvprlepsIAGYAAlwrgaeRVGIMNNSFMRGAMTrsgf-pparLVPYGAAQSFHEALLNGt----iGAVVDET 732  Japanese rice
CAN64921      583 ltssytaslssmltANRLQMlqk-gsFIGYQKGSLVREVVNnlnf-gdssLKAYGSIEAYAHALTEGskkggvSAIIDEI 660  wine grape
CAN61321      356 slssmltvrrldsnVMDIEWlkatrsVVGCNGASFVRKFLEnvtkfeaadIKNISSQYQYPGEFHSGn----iSAAFLEL 431  wine grape
EEC84618      659 sltsmltvprlepsIAGYAAlwrgaeRVGIMNNSFMRGAMTrsgf-pparLVPYGAAQSFHEALLNGt----iGAVVDET 733  Indian rice
XP_002316840  583 sltsmltvqrmkpnFSEFEKlkkdklNVGCDDDSFVQQYLQdvlgfdhdkIKVFNRENNYTTEFERNs----iAAAFLEL 658  black cottonwood
CBI30648     1046 slssmltvqrldsnVMDIEWlkatrsVVGCNGASFVRQYLEnvfnfegahIKNICNQNQYHGEFQSGn----iSAAVLGL 1121 wine grape

O04660        734 PYVRIFLGQyCNKYKMVqt------pfKVDGLGFVFPIGSPLVADISRAILKVEESNKANQLENAWF 794  thale cress
Q8LGN1        718 PYVKLFVAKhPSEFVIVet------esVTNGFGFAFQKGSPLVQKVSREIEKLRRTEKLKAIENWWF 778  thale cress
Q9LV72        710 PYLKILLGEnPGHFLMVkt------qsTTNGFGFMFQKGSELAPNVSREIAKLRTSERLNEMERRWF 770  thale cress
Q9M8W7        677 PYLSILIGNyPNDFVMTdr------vtNTNGFGFMFQKGSDLVPKVSREIAKLRSLGMLKDMEKKWF 737  thale cress
NP_001063236  733 PYLRIFLKSyCDRFAMAggggg-gqpnKTGGFGFAFPKGSPYVADLSRAILALTESEEMNLIERKWF 798  Japanese rice
CAN64921      661 PYIKLFLAQyGDQYTMIepe-----ylTTNGFGFAFPKGSPLVPDISWAIAKLREDGKLDMIQQTWF 722  wine grape
CAN61321      432 PYAKIFTSQfCKNYTAGqp------lnRFGGLGFAFQKGSPLAADFSEAILTLSEKGRIKELEDKWF 492  wine grape
EEC84618      734 PYLRIFLKSyCDRFAMAgggggggqpnKTGGFGFAFPKGSPYVADLSRAILALTESEEMNLIERKWF 800  Indian rice
XP_002316840  659 PYERLFLNQhCKSYSGSka------tyRFGGLGFAFQKGSPFAADFSREILCLSEDGNITFFEEKWF 719  black cottonwood
CBI30648     1122 PHAKILTSQfCKNYTAGqp------lnRFGGLGFAFQKGSPLATDVSEAILTISEKRILKELEDKWF 1182 wine grape
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