Conserved Protein Domain Family
PBP2_TRAP_DctP2_like
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cd13676: PBP2_TRAP_DctP2_like 
Substrate-binding component of Tripartite ATP-independent Periplasmic transporter DctP2 and related proteins; the type 2 periplasmic-binding protein fold
This subgroup includes TRAP transporter DctP2 and its similar proteins. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Links
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Statistics
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PSSM-Id: 270394
Aligned: 29 rows
Threshold Bit Score: 391.587
Created: 6-Jun-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative chemical substrate binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic ectoine-binding protein from Teaabc Trap-transporter of Halomonas elongata.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                               
goetting:HRM2_08520  31 NIKFGHvapp-fhgQAKAADAFAAYVKEktqgriDITTFPtgqlggersMAEQVQSgtlQIAAltt-avlQNFVPQCAil 108 Desulfob...
BAL01293             49 TLTAIVagltedspSGQALKKFADLCNQysggsvTIDCFFntelgsvasCVESTAQgtiDIVStgt-syfSGYVPAIQvf 127 Oscillib...
EFY08056             31 NMRFANatn---qaAKDAAVAMIDVVQKesggtiQIKHFPdnmlgddrvAIESTIMgdiDIVLaqp-stlTSFIPDVYlw 106 Succinat...
EGA93568             59 TLKAAHvfqe-shpIHKGMELFAQRVNEntggavTVEIYPnsvlggeneQLQQLIQgsiDCDMvsgvamyQGYDARAGie 137 Clostrid...
EFM22655             62 MSLFAGslpq-ntpTGEALGLMAEYINKnangtiKAEAFYdtalgdatsMVQGLQQgtiDIGVcgt-ayySGLVPDVEvy 139 Selenomo...
EHG32885             45 LSVFAGsvae-ntpTGTGLKAMVDYINEngggtlKATDYYdtalgdatsMVQGLQQgtiDIGVsgt-ayfSGLVPEVEvf 122 Clostrid...
NP_880562            28 DIKLGHvlap-shsWNKAAEGFAAEVKEktagrvNLILFPsgqlgnektMLEGLQIgsqGAAIigs-gslQPIEPKFGiv 105 Bordetel...
EHL70820             28 TIKIGHvlnt-dhsWHKNLAGFANDVKKetegrvTIQLYPsgqlgnekdMVEGLTFgtvDGGLigg-gsfQSIDPKFGie 105 Synergis...
EFK39447             35 ELKLGHamse-gtnATNLIHEFAVKVGEetegrvKIEDFPnsqlgsetdMLEQIQLgslDAGAimt-gsmQAIEPKMAie 112 Peptonip...
EHJ94838             25 DIKLGHvlap-thnWHVSAEGFADDVKEatdsrvNFQVFPsgqlgnetrMVEGMQIgsmEAGIigc-gsfQSLEPKFGiv 102 Halomona...

Feature 1                                                                                   # #         
goetting:HRM2_08520 109 dMPFIFp--dRQTAYATlddpevqERIFSYFPKK-GFIAIGWtENEIRDFTNNkrpvrtpEDIKGLKVRVMnsPAYIDTF 185 Desulfob...
BAL01293            128 eLPYIFn--sYDEAHKTldg-epgQEIANLFEPT-DLKMLCYwESGMRHVTNSrnpiitpDDMSGLKIRTVvsPTQQATW 203 Oscillib...
EFY08056            107 dAPFLFa--tAEDAIRCfns-digKTINGKVESR-NLHYFTMvGNGFRHYTNNkvavkvpADVAGAKVRVQesEIQMAQW 182 Succinat...
EGA93568            138 dLPFLFt--sAESAHKAldg-eygVKLAEEVLEPvGTKVINYwENGMRHFTNDvrpivtpSDMKGIKFRSAnsPIRIKMF 214 Clostrid...
EFM22655            140 qLPFLFegldAARAATArts-pscQAVFAKMSDK-GLVGLSFwENGFRELTNNvrevktpDDLKGIKMRTLpaPVQVATW 217 Selenomo...
EHG32885            123 qLPFLFd--nLEEARAAvdg-aasEKIFEKFAEK-GIVGLAFwENGFRELSNNvrpvttpADLSGIKMRTLpaTVQVETW 198 Clostrid...
NP_880562           106 eLPYTWt--tSQQAYKAydg-elgAALAKLAEKK-NLVIVSWwENGFRHLTNNrgpvntpADLNGLKTRVTpdKMRLDTF 181 Bordetel...
EHL70820            106 aLPYAWp--tHEAAYKAfdg-klgKYLFDLLGKK-GIVGLAWwENGFRHITNNkkpvvkpEDLKGLKLRVTpdKMRLDTF 181 Synergis...
EFK39447            113 dLPYMWk--dIDHARNAfdg-efgDYLGKLMENY-GLQKIGFiEWGYREITNNkrpivkpEDLKGMKIRVAqnKLRVDAF 188 Peptonip...
EHJ94838            103 eLPYSWa--nREAAYAAydg-elgETLETLAQEK-NIKILSWwENGFRHVTNNrgpidspEDLEGLKIRVTpdRMRLDTF 178 Halomona...

Feature 1                          #                ##  #                    #                          
goetting:HRM2_08520 186 KQLGasPVGIPFpEIYNALQTGvIDAQENPLMTTVLMkfTEVTKYVTKTQHCLTECIIVVGMdywesLADGDKQIFMDAA 265 Desulfob...
BAL01293            204 EAFGaiPMALDMgEVFTALQNHtVDAQENTLSSIVSYkmYEVQSYLSLTHHSYTAMPFFINRakwdsLTEDQQAAIQQAS 283 Oscillib...
EFY08056            183 KAWGanPTPMAFaEVLPALQQGtIDAQENPLAIIDANklYEVQHYISLTGHQYSPQILLMNKarwesLSDAQKKAMNDGV 262 Succinat...
EGA93568            215 EACNasVVPMQFsELYTALQQGtVQGQENPIPLIETSnfDEVQKYLSLSGHIYNATVLAFNPdkwnsLSPELQEVIINAA 294 Clostrid...
EFM22655            218 EAMGasATTIDAaELYTALQQGtVQAQDNPLHEIVARkfYEVQPYVTMTDATYTPLLLSMSKvtfdkLSPSQQQLIMEAA 297 Selenomo...
EHG32885            199 KALGalPTTIDAsELYTALQQGtVSAEENPLHEIVSRkfYEVQQYITLTDHVYTPFMMGISQktwdkLSDQQKSVVMDAA 278 Clostrid...
NP_880562           182 TALGanPAPLAFgELYSALQQKvFDAQENPLSIIYTSsfFEVQKYLSLTGHVWGPASLIVSKpiwnrISADDRKIVQAAA 261 Bordetel...
EHL70820            182 KLLGaaPMAINFgELYSALQQGvVDGQENPYAIIYSNafNEVQKYLSKSGHIWGSAVLCVNSdvwnkLSAKDKETVRKLA 261 Synergis...
EFK39447            189 EKLGalPTMLAFsELYGALQQGvVDSQENPLANIVAAnfNEVQKYLSITDHFYNQAMVVVNKdtwekINEDDRKIILDCM 268 Peptonip...
EHJ94838            179 EALGsnPAPLAFgELYSALQQGvFDAQENPLSIIYSSsfYEVQDYVSLTGHVWAPACLTIADltwnkINPDDQQVIQELA 258 Halomona...

Feature 1                                                                                          
goetting:HRM2_08520 266 KLATGvnrsvnaalheslpKINISIADYAKQHdIEIIELTpd--eREAFRVSMTPVWNKYRk-rIGDDIFDFMLD 337 Desulfobacter...
BAL01293            284 EESRDyerq------lnseGEAECLKALADAG-VQIEENPd----TEAFAALCGPVYDIFTdsmGSDEYLTMVQN 347 Oscillibacter...
EFY08056            263 ETFIKvqre------rsieLDALSEKKFKDAG-CEIITLTdaerqQWIDKAKEGGVYDLVKsmmDTPEYVDRVLN 330 Succinatimona...
EGA93568            295 NEARDyere------lnakESDDAVERLKSKG-MEVNEVD-----KSAFVEAVQPVWDTFKk-eNGSELIDLAVS 356 Clostridium s...
EFM22655            298 DWAREkqia------itneKQATALQTLKDHG-CKIVENPd----KKAFQDKAMASWELYTk-pNGTAILDLIRK 360 Selenomonas s...
EHG32885            279 NAGKEaqrk------aneeKTIEAKQVLLDNG-CEIVENPd----KEAFKEIAVSAWKVFTd-eNGTELLDIIQK 341 Clostridium c...
NP_880562           262 DKWRDaqrq------miteGDLQFVAQLKEKG-MQVNEVD-----KAPFAAAVAPIWKTYEt-aYGPELMGLLQK 323 Bordetella pe...
EHL70820            262 QKWCAaqrk------etikEENEFLDKLKAKG-MKVNDVD-----KAAFQKAVQPVWKSYEs-tFGKELMDMVHE 323 Synergistes s...
EFK39447            269 NELSEkikd------andkDHNSYIETLRSKG-MEINDNVd----KEAFRKAMLPVYEEWSa-tFGDELMKIYNE 331 Peptoniphilus...
EHJ94838            259 DKWRDkqra------mtreDDETMLENLTAEG-MQINEVD-----TAPFNQKVQGVWNDYAe-vFGEELMETVRQ 320 Halomonas bol...

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