Conserved Protein Domain Family
PBP2_Bug_NagM
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cd13579: PBP2_Bug_NagM 
Uncharacterized NagM-like protein of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold.
The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.
Links
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Statistics
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PSSM-Id: 270297
Aligned: 19 rows
Threshold Bit Score: 342.331
Created: 9-Mar-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative chemical substrate binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the BUG family.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #   ###                                                              
AAD12622    41 SGPGVATIVIGLaaGGATDMAARRLSEGMrg-aYASSVLVDNRTGAGGRIAIQHVKAaapNGATLLLTpaSMMTLYPHty 119  Ralstonia sp. U2
NP_767067   57 AQAGLSKIIFPFaaGAGGDTLCRLIAQEMap-vLQRTIVVENRTGGDGLIGIKAVKGaspDGSMVLVTtgPTMYLLPMve 135  Bradyrhizobium j...
YP_298980   27 QEKQPIKFLVGFppGGSTDTVARVLAEKLqg-eLGQTVIVDNRPGAGGRVATGILKHsapDGLTYMVApnATAIFPTLly 105  Ralstonia eutrop...
YP_547061   28 QALDSTKVIAGFapGGTADIVSRRVADKLhp-gYAKSAVVENKTGAGGQIAVQFVKNaapDGATMLLTpmSMLGIYPHty 106  Polaromonas sp. ...
YP_548600   39 PAIETLHILSGSaaGSTPDIVARHVAEQLsg-rYAKTAIVDNRPGAAGRIAMNALKLaptDGSTVCLAagSIATVNPHiy 117  Polaromonas sp. ...
YP_728496   27 QDKPPLKLLVGFapGGSVDVVARLLAERLrl-pLGQQVIVENKPGAGGRLVLGEAKRapaDGNTLVISpsGALVISPWly 105  Ralstonia eutrop...
YP_997697   35 AAAGPIRVLVGFppGGATDVVARALIDRLgkqmDGQVFIVQNQSGAGGQIAAQLLKAappDGATIMLSidHTQVIIPLtv 114  Verminephrobacte...
YP_785511   24 QAAPVTRILVGFspGGGVDVIARLLARQIeg-gLGEVVVVENRVGAGGLLAAQAMLAaapDGRTLLLTndHTLSILPHtl 102  Bordetella avium...
EEC80776   419 QAGRTLRILVGFppGGGSDAIARLLADKLkd-vLGVPVVVENRPGAGGQIAAQVLKTsplDGSTVFLThdHTISILPQvv 497  Indian rice
YP_524434   30 AQTGPVKLMVGFppGGGTDAIARILADKLkd-pLGVTVVVDNKAGAGGQIAAQALKAapaDGNTLFLShdHTITILPLvl 108  Rhodoferax ferri...

Feature 1                                                                      ##              
AAD12622   120 kdl--gydpvKDFVPVGMVs-TSEVGFAIGpavpesvgsLNDYLAWIKsnp-dsATFGHGatgsGPHFLGELLGRLLGVK 195  Ralstonia sp. U2
NP_767067  136 ttp--sfdtaKDFMPVSLLa-RFEFAVVIGpaid--aadFKSFVAWLKahp-dkTSFGVPsngtIPHFMGSKLEKDLGIP 209  Bradyrhizobium j...
YP_298980  106 ppatlkydllTDLTPVAVVi-SYPLALVVStqtg--vtdMKGFVEWVKahp-gkAMFGTAglggQTHFTGLQFGKAIGVP 181  Ralstonia eutrop...
YP_547061  107 kkl--pydpvADLTPVSAAa-VFDYGFAVGpmvpasvktVPEFLAWCKanp-tlANFGSPaagsSPHFIGALLGRAANVD 182  Polaromonas sp. ...
YP_548600  118 anl--gydpaVDLQPVSLAa-EMPLALAVGpavpdsvvnVRDFIEWMRrnp-tlANVGSPgvgsLPHLLEAVLFRQADVA 193  Polaromonas sp. ...
YP_728496  106 hln---ydpvKDFTPIARVv-TFDFAVTAGpaap--agdIRAVLNWLKanp-arANYGTSgagtVPHFAGVLLSQASGVP 178  Ralstonia eutrop...
YP_997697  115 aaa--gyhpvNDFTALAGVa-KYYNVLAVGsstr--iktLPALGAWMKahs-sqANYGIPaagsVPQFIGQIVGQSFGVA 188  Verminephrobacte...
YP_785511  103 kkp--gfaspDDFAPVAQItdKSILGLAVKadsp--lrtLQDLKTLSGp-----ISIGVPapgsIPEFAVELLGERMSLP 173  Bordetella avium...
EEC80776   498 khp--gfdpaHDFIGVGGVa-TFVNAFAVSggtp--arsFDEYVAWVKsqg-gkSAVGIPapasTPEFLVKLLGERYRLD 571  Indian rice
YP_524434  109 knp--gydasKDFMPVAGFa-TFVNGLAVSggtp--aksMAEYVAWVQkegagkDTVGVPapasVPEFLVKVIGQKYKLD 183  Rhodoferax ferri...

Feature 1                                #                                            #        
AAD12622   196 MVQTGFRGsqPAIVDLLGGhiPAVAAPlgEFLPHMktgKIRVLGVTgaNRSRfLTNVPTFKElhiaLSEMTEWFGVFMPA 275  Ralstonia sp. U2
NP_767067  210 LTRVPYRGsaPILNDLIGGhlSFGIVTlaDALPQHrakGVKIIAVSsaERSPfAPEVPTLKEsg-iALVADAWYGMWLPV 288  Bradyrhizobium j...
YP_298980  182 MNVVPYKGngPLITDLLGGqlAAAVMTagDILPHAksgKVRILAVFgaARSPlLPGVPTATEqgvaVDSGEAWAGIWAPA 261  Ralstonia eutrop...
YP_547061  183 LRHVAFRGtqPAVLDMIGGqiAAVSGPtgEFTQHVaagKCRLLSTSgpRRGKfTPNTPTLLEqgfkDMAFTEWFGFFLPA 262  Polaromonas sp. ...
YP_548600  194 WRHVGYSGgaPTVVALLGGqiAALVLPeaVLGQHRaagKLRVLATSgaQRSRyMPDVPNLVEqgyrELVVSEWFAFFMAA 273  Polaromonas sp. ...
YP_728496  179 LTHVAYKGgaPAVSDLLGGqiPIMVDTisETIEHHragRLRILAVTgnARSPaLPDVATLKEsg-iDATAEAFVGLFAPA 257  Ralstonia eutrop...
YP_997697  189 LNPVPYKGgaPMVQDLLAGqvPIGIASmtELIEHHragKVCILASSgtERSRiAPEIPTFAElgfkRLEKNPWLAFFGPK 268  Verminephrobacte...
YP_785511  174 IAAVPYRGgsPLVMDVQGGhlALGMTSlaELLEPMragRIRLLVVSgsGRHPdIPEVPTFSEeginGMEQGGVVGLFAPR 253  Bordetella avium...
EEC80776   572 LVSAPYRGsaPMIGDMLGNqiAAGVGSvpDFLENHkagKIRIVAVLgdRRQAaLPDVPTFGElglkGFEDLPYYGFYAPA 651  Indian rice
YP_524434  184 LQAAPYRGsaPMMGDMLGNqiHAGVGSvpDFIENQkagKIRIVAVLgaQRQAaLPDVPTFAElglaGFEDVPYYGIFAPK 263  Rhodoferax ferri...

Feature 1                                                                  
AAD12622   276 GTPaQAVQQASAAMKSAVAnPELVKAYAMm-GMEAGwssPEGLSDRLKNDIKRWQAVAEK 334  Ralstonia sp. U2
NP_767067  289 GSPpEFASKLGAAASAALAkAEVKEKLTAi-GLIPVgssPDELTKELAANTAFWQPIVKA 347  Bradyrhizobium japonicum USDA 110
YP_298980  262 RTPkAELDRMQAALGKVLAmPDVRTTLQQraTLHPDfrpAAELDRLQRKELAYWGPVIKA 321  Ralstonia eutropha JMP134
YP_547061  263 KAPqDVVQRLNSAIRAALAsQDVIDGLAVs-YLEVMptsPAQLAAMLKADTELWGPLVKA 321  Polaromonas sp. JS666
YP_548600  274 RVPaAMIDATSQAIRLAIArPELAGAFAEl-GMVAAsstPAELAARIAAERRYWEPIIRA 332  Polaromonas sp. JS666
YP_728496  258 GLPaDKVKRLSDAIAEVLKaPDLQARIREi-GLNANyagPQQLGETQVADLRRWERPIKA 316  Ralstonia eutropha H16
YP_997697  269 GLPaEFVAQFDQAMHAVLAqPDLQERLAKm-GNEVAaapAKEVQQWVIDASQHWGQVIRE 327  Verminephrobacter eiseniae EF01-2
YP_785511  254 GLPqARADLLQGLVARALEsEEMHRQMQVl-GTQVNfgdATTLAHNMKAIHQAWALRAQR 312  Bordetella avium 197N
EEC80776   652 GTPaKAVQQFSDALAKVLArADVREQLVAm-GLTRQsaaPAGAGVVGRQCGHERLFHQRL 710  Indian rice
YP_524434  264 GTPqAAIDKLSAAVAKVIAlPEVRERLTAm-GLTVGymtSAQLASREHAYAQTWARIIKD 322  Rhodoferax ferrireducens T118

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