2DVZ


Conserved Protein Domain Family
PBP2_BugE_Glu
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cd13577: PBP2_BugE_Glu 
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Glutamate transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold.
The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.
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Statistics
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PSSM-Id: 270295
Aligned: 11 rows
Threshold Bit Score: 369.75
Created: 9-Mar-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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chemical
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding site [chemical binding site]
Evidence:
  • Structure:1DVZ; Bordetella pertussis BugE with bound glutamic acid, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #   ###                                                              
2DVZ_A        16 YPSKAIRVIVPFapGGSTDIIARLVTQRXsqeLGQPXVVENKGGAGGAIGASEAARaepDGYTLSIAtvSTXAVNPAcrp 95  Bordetella pert...
NP_884092     27 FPERPITLIVPFpaGGPTDIVGRVAAAKAgeiLGQQIVVENRTGAAGTIGITATARakpDGYTLGLAtvSTHGTAPHlfp 106 Bordetella para...
NP_886418     29 YPQRPITLIVPFevGGPTDILGRIVAETLsakIGQTVIVENKGGAGGAIGSEAIAKaapDGYTIGLAtiSTHVVNPScnk 108 Bordetella para...
YP_970271     35 YPSRPITLVVPFppGGSVDVMARQYTESLgriLGVPIVVENKPGAGGSIGTQFVARapaDGYTLVASsqSSHLANPLvqp 114 Acidovorax aven...
YP_985173     56 YPNRPIKLIVPFapGGSTDMVARLLADKMgpiLGKAVVVDNKGGAGGSIGADAIAKaapDGYTIGMAtvSTHGANPAiya 135 Acidovorax sp. ...
YP_988174     23 ASSSTLRLVVPFpqGGATDITARVLAGPLsriLGMPVKVDNLPGAGGATGMQAVAKaaaDGMTLGVAtlSTHGVNPAvyk 102 Acidovorax sp. ...
YP_001564186  37 PTAEPIRLIVPFppGGTADVVNRLFAQQLgkvLGASVIVENKAGAGGSLGTRFVADakpDGYTLLGAtsSTHGTNPAvyt 116 Delftia acidovo...
EEC77198     159 YPSKPIRLVVPFapGGTTDIIARVIADPLaraLGQPVVVENKAGGGGIVGASDTAKatpDGYSLGIAtvSTTAANPAinp 238 Indian rice
YP_002554346  39 YPSKPVKLIVPFaaGGSTDIVARVLAEGMrqtLGQSIVVDNKAGAGGLLGTEALANaaaDGYTIGMAtvSTMTINPLlyt 118 Diaphorobacter ...
NP_882173     39 YPSRPVTLVVPSppGGSTDAIARVLADALgkrLGQSIVIENKGGGGGIVGSSYVLDkpaDGHTLLLAisSKTVARALqpa 118 Bordetella pert...
NP_887297     32 YPERPVTLVVPFatGGNSDIVARLIAERMgqaLGQTVIVENRAGAGGLVGNQAVARakpDGYTLLLGgmSTQILLAGtap 111 Bordetella bron...

Feature 1                                                                  ##                    
2DVZ_A        96 kdlpydpiKDFQPVTNFaNTANVVAVNpkfpakdFKGFLEELKknpgkYSYGSSgtcgVLHLXGESFKXATGTDIVHVPY 175 Bordetella pert...
NP_884092    107 nl-aydpvKDFTPVSNLvTSPNILSVNpsypaadLGAFVAHVRanpgrDGYANAgaggVNDLGMIWFLQLIGGKMTSIAY 185 Bordetella para...
NP_886418    109 hl-rydplRSFTPVALLgSMPNILVVRqgfgtpdFAAFRERLKkdseqYNLGTAgpcsFGHVMLEHLNQELGSRIAHVPY 187 Bordetella para...
YP_970271    115 kl-gydpiKDFENIAIMgRQPNVLVVHpsvpvktFAEFVAYLKanpgqVNFATAgagsMGQINAEAFLLAVGAKGVHIPY 193 Acidovorax aven...
YP_985173    136 kl-pydavKDFAPITNVmSVPSVFVVHpsvpaktMQEFVALAKanpgkYTFASPgtgsLGHANIENFMNLAGIDLLHIPY 214 Acidovorax sp. ...
YP_988174    103 kl-pydaiKDFAAVTEIvKAPGVLVVHpsvpaqnFEQFIKLIKsqpgkITYATPgagtIGHMWAELLQSTTGTSMKHVPF 181 Acidovorax sp. ...
YP_001564186 117 kl-pydavKDFTPITQViTVPGVLSVHpsvkaanLKELIALAKaqpghLSYASSgaggLGHLAMELFKAKAGVQIMHVPY 195 Delftia acidovo...
EEC77198     239 rt-pynplTDFTPIINIaATPNIIAVNpnfpakdYKGFLAEVKkvpgkYSYSSSgtggIGHLQMELYKSLTQVFVTHIPY 317 Indian rice
YP_002554346 119 ra--anlgAKLTPVANLvTMPSVYMVHpslgvnsFEAFVAKAKaqpkqISGAVPgpgtLGHLMLASFNETLKTDILVVPY 196 Diaphorobacter ...
NP_882173    119 la--ydpiRDFTAVALVsRVPTVMVTSvaaglpdFARLKAYIAanpgkTAWAVPgigtAPHLTEHVLMQALGGKVNEIQY 196 Bordetella pert...
NP_887297    112 ql-pydpvKDFSAVALIsKVPLVLVVPasspaqdLKSFAEYLRqkpgaYNFSSAgagtSGHVTAQYFADAIGAKVVHVPY 190 Bordetella bron...

Feature 1                            #                                               #           
2DVZ_A       176 KGsgPAVADAVGGqiELIFDNlpSSXPQIqagKLRAXAIAwpTRIDaIKDVPTFADag---fpVLNQPVWYGLLAPKGTP 252 Bordetella pert...
NP_884092    186 RGsaPALTDAVSGvvPVIFDNfpSSLPYIksgHLRPLAITgaARNPrLPEVPTFAEqg---yrDYDVTAWYGVVAPAGLP 262 Bordetella para...
NP_886418    188 RGsgPAASDLLGGslDMMMDIypLLGPHIaagKLTALAVAwpSRLSrLPDTPTFDElg---lpDLSTTSWYGLVAPAGLP 264 Bordetella para...
YP_970271    194 RGgsPYVTAILAGevQFALDNlvVFLQHIqagKLRALAVAsdTRVAqLPDVPTFKElg---fpDLNQPSWTGIAAPAGTP 270 Acidovorax aven...
YP_985173    215 KGagQAATDALAGqvNAMTDNlpSTLANIqsgKLRPLAVLalKRSPvLPDVPTYTElg---yaGMGDGGWFGLVAPAGTP 291 Acidovorax sp. ...
YP_988174    182 RGaaPAVADLLEGkvQVYCDQvaSSLPHIqagKLRALAVSwnQRLAvLPKVPTYAEls---lfTNNDPSWFGLVAPAGTP 258 Acidovorax sp. ...
YP_001564186 196 RGagPAFTDLIGGqvSMLWEPlpASLPHIksgKIRPLAVAtaQRSSeLPDVPTFAEsg---vpGYAVQAWNGLLAPKGLP 272 Delftia acidovo...
EEC77198     318 RGagPALNDTVAGqvPIIFDNlpSTLPFIkenRLVPIVVAapQRVAaLPNVPTFKEig---lePVNRMAYYGILGPKGLP 394 Indian rice
YP_002554346 197 RGngPALNDALAGmvQVMPDQlpSSLPHIksgKLIAVALAseSRSPeLPNVPTFKElgy-ndlNQLGISWFGIVAPKNTP 275 Diaphorobacter ...
NP_882173    197 RGsaPMHVDLLAGrvDVVVDSytALRQHIddrKVVPVAVIgrGRIEaMSAVPTLGElgyrtfeEVLFDGWNAIDVRASTP 276 Bordetella pert...
NP_887297    191 RGssPALVDLVEGrnAYLVDTppVIKELVksgKIRALASFteTRLAdLPEVPTVAEaglgeviKEKMQPWQALFVPAGTP 270 Bordetella bron...

Feature 1                                                                  
2DVZ_A       253 xDVVNKLRDAAVVALKdPKVIKALDDq-GSAPSgn-tPEEFAKEIKEQYDWAQDVVKK 308 Bordetella pertussis
NP_884092    263 dAVRDKLAQAFAQAVRdPATAAKMEEt-GAFPLgn-tPAEFAAQIQAEQARWKTVIEK 318 Bordetella parapertussis 12822
NP_886418    265 aDRLAVLSRKIGESLQdPGLRRRFEEayIHAAPqe-sPQAFKDFLAAQFSKESAFIQS 321 Bordetella parapertussis 12822
YP_970271    271 aAIVATLHKAIRKAATePAMVENLKAr-GVIPPeemsPAAFEKMMSERLASYGEVVRK 327 Acidovorax avenae subsp. citrulli AAC...
YP_985173    292 kEIIAKLNAAAHKAMAqPDYLEKQKSi-SGESMan-tPEQFAKQIDAAIARYTAVAKR 347 Acidovorax sp. JS42
YP_988174    259 aVVVRARRDAVAQALEePAVRKALADh-GLFPSgs-lPAEFGAQIQKEVDKMRRVSRF 314 Acidovorax sp. JS42
YP_001564186 273 kDIRDKLHKASVQALAdPQLRQRLAEl-GGTVVan-tPEQFGAVILKDVTTWKQVASS 328 Delftia acidovorans SPH-1
EEC77198     395 rDVVDKVNAGVRKALEdPAVRKRIEDt-GSLIVgn-tPEQFAEQIKAEFDVYKTVVQN 450 Indian rice
YP_002554346 276 aAIVKRLQEAAVKAAHlPDVQKRLKTl-GATPTdm-dQSQFAAQITAQTQRHKVLLDK 331 Diaphorobacter sp. TPSY
NP_882173    277 pEVVARLSQALQDVLAdRAFRERVVQl-GLVPFapmpASQAQDFVQDVSRVLSPVAAS 333 Bordetella pertussis Tohama I
NP_887297    271 pEVEARIHDALGKAMAdPALQQRLTQm-GLVPMsg-sLADAKQLFEVDYAKWIPILDG 326 Bordetella bronchiseptica RB50

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