2F5X


Conserved Protein Domain Family
PBP2_BugD_Asp
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cd13576: PBP2_BugD_Asp 
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Aspartic acid transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold.
The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.
Links
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Statistics
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PSSM-Id: 270294
Aligned: 9 rows
Threshold Bit Score: 411.764
Created: 9-Mar-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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chemical
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding site [chemical binding site]
Evidence:
  • Structure:2F5X; Bordetella pertussis bugD with bound aspartic acid, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #   ###                                                              
2F5X_A        14 YPERPVNXVVPFaaGGPTDNVARSLAESXrptLGETVVVENKGGAGGTIGTTQVARaqpDGYSILLXhaGFSTAPSLykn 93  Bordetella pert...
P70791        50 YPSSPVTIMVPAaaGGPSDTVARLVAQSMsktLGQQVLVENMGGAGGSLGAANVAKadpDGYRLLLYhiGVATFAALypn 129 Agrobacterium v...
NP_771416     60 YPSHPITIIVPFaaGGPSDAMARVLAERMrttLGQPLVIENVTGAGGSIGVGRAVHspaDGYTISFGhlGTHVANGAvyk 139 Bradyrhizobium ...
NP_772362     27 FPKRPITMIVPFaaGGTSDVIARTVAEQMsvaLGQTIVIENVAGAGGSTALARASRaepDGYTIAIGnaGTNAATYTiyp 106 Bradyrhizobium ...
NP_773153     30 YPTRGITMIVPFaaGGPTDVISRIVTAHMaqtLGQSIVIENVVGAGGTTATARAARaanDGYTLITGhmGTHAASVPlyp 109 Bradyrhizobium ...
YP_972201     24 FPEKPVTIIVPYaaGGPMDKLARQVGSQLgtlLGQPVVVQNQGGAGGNIGVATAKRaapDGYTVLLDhvHMATAPALyrk 103 Acidovorax aven...
YP_999313     29 YPARPVTWVVPFaaGGPTDALARAMADRVargLGQPIIIDNAPGAGGTVGTAKASRaaaDGYTMLVGhmGYMGAAPAlyk 108 Verminephrobact...
YP_001562001  38 FPARPVTLVVPFppGGPSDALARAVAQKMgehLGQPLVIENLGGANGTIGLNQARKaaaDGYTLSFGgiGTHVVNVAlyr 117 Delftia acidovo...
YP_001563589  28 FPNKPVTIVVPYaaGGSTDVLARVLAEAMtrdLGQQVIVENLGGAGGTIGTSRVTRaqaDGHTLLLHnmGIATAPALysk 107 Delftia acidovo...

Feature 1                                                                 ##                     
2F5X_A        94 pg-yepyTSFEPIGLVvDVPXTIIARgdfppnnIKELAEYVKknadkISLANAgigaASHLCGTXLVEALGVNLLTIPYK 172 Bordetella pert...
P70791       130 la-ykpiEDFSSVGLItEVPMTIVGRkdlepktFADLVAIVKknattVTFGTAgtgaVSDLCGRLLQDALGTKITLVPYK 208 Agrobacterium v...
NP_771416    140 ln-ydlvADLEPVVLLpSNPMIVVSKnavpatsLKELLDWLKsrpsaATAGTAgagsGSHIAGVYFESVSGIKLQYVPYR 218 Bradyrhizobium ...
NP_772362    107 kl-pftpDSFVPIAMVaKTFGIIAVRkdfpakdLKEFIAYARanpakINLGHAgvgsSNYLICKSFVTAAGIDATLVGYR 185 Bradyrhizobium ...
NP_773153    110 klayhpeKDFEPIALLaGTPILILARkdfppkdLKEFVTYVKanaekVNAAHAgvgsVSHVSCELLHAILDIKPVGVPFN 189 Bradyrhizobium ...
YP_972201    104 ld-fapdVDFEPLGVIaESPLVLIGRpgvpggsLDELLRWMAqq-pqVTLANAgmgsASHLCGLLLQSSLKLRMTTVPYK 181 Acidovorax aven...
YP_999313    109 klaydpvKDFAPVFRFpDTPLVLMVRkehpakdIEALVGFGKanpdkLFISNAgvgsSSHLIAALFAASAGIKISQVPYK 188 Verminephrobact...
YP_001562001 118 klpydpvADFAPVGPAgAAPMLLLARanlpasdLRQFAEWLKrnqaaASYGSAgvgsISHYGCVLLLSALGQSPTHVPYR 197 Delftia acidovo...
YP_001563589 108 la-fdvrRDLEPIALAgDVPMILVRSkgfapatLADFIAHMKakpgeVRFSHAgvgaTSHLCAMLLLQTTSTEATLVPYR 186 Delftia acidovo...

Feature 1                           #                                              #             
2F5X_A       173 GtaPAXNDLLGKqvDLXCDQttNTTQQItsgKVKAYAVTslKRVPt--LPDLPTXDEsgykGFEVGIWHGXWAPKGTPkP 250 Bordetella pert...
P70791       209 GmgPAMTDLIGGriDLACDQttNTTTQIkanEVHAYAVTtkARIDv--LPDVPTVDEgglkDFELSAWHALWAPKDTPaP 286 Agrobacterium v...
NP_771416    219 GtaPALNDLIAGqiDVIVDQtsNSINQVragTIRAYAVTddKRLSs--APDIPTAEEaglkGFHMTLWSGMWVPKGTPkE 296 Bradyrhizobium ...
NP_772362    186 GaaPALTDAIGSqiDGVCDAaaSVSQSInekLVRGLVVGstVRLAt--LPELPTSAEaglpEFEAQGWNGLFAPKGTPpA 263 Bradyrhizobium ...
NP_773153    190 GtgPAMNALVAGqvDYMCDQivNAVPQInagTIKAYAIAtaERNPs--LPNVPTTTEaglpAFQAQAWNAMFAPKGTSpA 267 Bradyrhizobium ...
YP_972201    182 GtgPAMIDLMGGqvDLMCDLtsNAMPQIqsgKVRPIAVTvrEPISgtpLETVPSVEKfgitQSPLTIWYGLYSPRGTPaP 261 Acidovorax aven...
YP_999313    189 GagPALVDVIGGqvDGIFDQtnTALPQIeeaKVRALAVTskARLAq--LKDVPTLGEtvlpGFEASTWYGIYAPKGTPqA 266 Verminephrobact...
YP_001562001 198 GiaPAMNDLMGGqtDFMCDQttTALPQIaggRIKAIAVLgtQRLAq--LPGTAASAEag-hPLQARSWNAIFAPRGTPpA 274 Delftia acidovo...
YP_001563589 187 GtgPALQDLVAGnvDVICDQpvATGPHIqagMLKGYAVAtrERLPs--LPDVPTFAQagqpGFELAVWHGLYAPRGTPqA 264 Delftia acidovo...

Feature 1                                                                 
2F5X_A       251 VVDKLVKSLQAGLAdPKFQERXKQlGAEVLtne-anPEALQAKVKQQVPQWAELFKK 306 Bordetella pertussis Tohama I
P70791       287 IREKLSEALKTALKdPMVIERFASlGTVPVaqdmatPAALDQKFKAEVERLAKVISE 343 Agrobacterium vitis
NP_771416    297 IVTKLNAAAVEALNdPAVKKQLESqGLEMTpqdqltPEALGTRQKAEIAKWWPIIKA 353 Bradyrhizobium japonicum USDA 110
NP_772362    264 VIARLNAAARTAVEtDAVKKRFADlSTVAPddnehtPELLQQLVTRDVEKYRKMLAD 320 Bradyrhizobium japonicum USDA 110
NP_773153    268 IVASLNAAAVKALEdETVRKRLLElGSVIPgpkdrtPEALATLVKNEIAKWTPVLKP 324 Bradyrhizobium japonicum USDA 110
YP_972201    262 VIQQLSTALKTVTNsATFRKQQADaGLKPVtderltPAGHRRYLQEEINRWAGPIKA 318 Acidovorax avenae subsp. citrulli AAC00-1
YP_999313    267 VLDKVQQAYLKVMRdKAFTDRLAEqAIQMLppeqytGSALGKHTEAEVMRWKAVAAK 323 Verminephrobacter eiseniae EF01-2
YP_001562001 275 VLARLTRSLQHAMGdAGLRAQMAAlGVELPspeqavPATVSALIEQGLRNDVPALKA 331 Delftia acidovorans SPH-1
YP_001563589 265 VIERLNKSLRTALSePALVKRFTDmSVIIPpadrltPDALRQHTTAEIKRWDPVIKA 321 Delftia acidovorans SPH-1

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