4G6U,2GKP


Conserved Protein Domain Family
CDI_inhibitor_EC869_like
?
cd13445: CDI_inhibitor_EC869_like 
Click on image for an interactive view with Cn3D
Inhibitor of the contact-dependent growth inhibition (CDI) system of Escherichia coli EC869, and related proteins
CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring bacteria. This model represents the inhibitor of the CdiA effector protein from Escherichia coli EC869 (which is a DNAse). CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered. The inhibitors are intracellular proteins that inactivate the toxin/effector protein. This domain is also known as DUF1436.
Links
?
Statistics
?
PSSM-Id: 259838
Aligned: 33 rows
Threshold Bit Score: 108.859
Created: 5-Apr-2013
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
CDI toxin
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:CDI toxin binding surface [polypeptide binding site]
Evidence:
  • Structure:4G6U: The CDI inhibitor from Eschericha coli EC869 binds its cognate CDI toxin domain, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1        # # #             #  ##   ####                                                  
4G6U_B         8 DYWANIFVT-PDFLSVETYSGLG---XTGRDPLFSPRLLQpDVDDKSLGEEILQALSDSRTLDvleerva---ffdlekS 80  Escherichia col...
ZP_12490226    4 PKAAFVRIN-KDFLLVTSFIRGM---IAMTDPDQDFIFNEvDISDLDLGKLIKEKLNESKEISfeefqa----ifnsekM 75  Haemophilus hae...
ZP_05825156    1 MKHVNVYFN-SQYIEVTSWNDGG---CWLLNLDFEPIKLStNVKNKILGESIQIALNAGKNIPpenvkn----ilfspeL 72  Acinetobacter s...
ZP_02154642   31 RKSAFVTSY-RKFTEIASQAVYG---SAHLDPKGYHEYLPpDLTALEIAGHARAALLASRFITpkhpewd---dviripT 103 Oceanibulbus in...
ZP_10125954    2 KQSILIKKT-DKFVLIYSYLVGR---ILRVDAKQQVSYSNtNIGDLDLGKKIREKLSESHSITeelfmdi---wkhrneL 74  Pasteurella bet...
YP_004419350   2 KKDIFLEKS-SKFISITSKLISR---LRFSDPNQIVSYLDiNISYIKLGQEIRKKLNESEQITdemfmyy---wnnkeiI 74  Gallibacterium ...
ZP_08696811   18 YKSCQINRT-DRWISVVSNVIFGg--LHFSPTGFAVHSSR-DVTPEWIGAAVRQALDTSEYLTpmediereplilmkasS 93  Acetobacter ace...
YP_001196014  15 IQSISVIKY-PDRIFFETYYKIV---NSYSTRSKEITISEiNISDFEIGKTILKHLDLSRTIKn--------------fT 76  Flavobacterium ...
ZP_06142287   35 PYHVDIYKGeGKIIIVPLITSAG---WYSTEMAWHRQITD-LENAELIGKIALEALKHIGNSPvd-------------aR 97  Ruminococcus fl...
AFI92508       3 KYDAIIYEFgDKYFIIQRSKQEKrhaESASENVALTAVLPtNVDITTLGKEALTAIDNYGLVDpa-------------yD 69  Pectobacterium ...

Feature 1           #                        #   #           #    ##     #####                   
4G6U_B        81 KEQYAAWIATLXEKYGYRTKRALFKNXKKVGIHLVn---DVITIRPSFHEKL----EAWSGnrinesDYVVL--PADSSP 151 Escherichia col...
ZP_12490226   76 KGLQKNLEEEMKKRYGYKNKKSIYKDMSFLSLEQDa---SFIIIAPLHQDSL----GGYSGislpdnSPLEFkyDKNISD 148 Haemophilus hae...
ZP_05825156   73 DSLMTERDKKLMAEFGYKSKKALFKHMRKVSITYIn---DTYKISPSHQDGLd---YSFTGls--kaDEIIL--PNDATD 142 Acinetobacter s...
ZP_02154642  104 KEEFKAWEEADKARAGVKTLKALFNGAGHVSLTLRd---GKIAIKPTRYRGH----GHWEGir--gqEDTVL--PEDVSV 172 Oceanibulbus in...
ZP_10125954   75 DEILQKKEEEIIKKCGYKNKNAFQRDISFLSVDIRn---NILFITPLHQDGL----DSFETvrdkdgQGVEFeyPVNLSD 147 Pasteurella bet...
YP_004419350  75 KEFNKNEEKRIMCNYNYKSRKALYQDVDFLSIEILn---NKLLITPLYQDGL----ASYTSvkgkdgFAIKFeyPLTIAD 147 Gallibacterium ...
ZP_08696811   94 NERRLAFWEDLASAYGYKNREATWNKYDSLFVRWFyevePDIEIVSTKSSRTga-hSAWPRnmn-egRVFHV--PFAASD 169 Acetobacter ace...
YP_001196014  77 KQERVENYEAYKKITGLKSIKAQMKDSVYVSISRQn---NQITFYPTINGGTsgqrKGYHFld---eEKIVI--EDSEDF 148 Flavobacterium ...
ZP_06142287   98 TKQEREDDSIWKNASTYKSYKSFNKNYILCGVILYe--dGKIIISPTEKLDGn---KGYGGn----dEGLVYl-SINNSP 167 Ruminococcus fl...
AFI92508      70 PWELKELRKQLCGWVGARSYTGLIKNCRIVLLYKDfd-eEKIKVIPFDNHNI----KAWESmm--ndEIIVL--PIDATI 140 Pectobacterium ...

Feature 1                       
4G6U_B       152 TEIGSGLRLALSRCK 166 Escherichia coli O157:H7
ZP_12490226  149 EELGKAIRQALTYCT 163 Haemophilus haemolyticus M21127
ZP_05825156  143 EELGQAVRLAYEKCT 157 Acinetobacter sp. RUH2624
ZP_02154642  173 EELGRAILDALDISR 187 Oceanibulbus indolifex HEL-45
ZP_10125954  148 EELGKAVKDAFEYCT 162 Pasteurella bettyae CCUG 2042
YP_004419350 148 EELGKATMDAFEYCT 162 Gallibacterium anatis UMN179
ZP_08696811  170 AEIGDMVLRTFSRCE 184 Acetobacter aceti NBRC 14818
YP_001196014 149 QSIGEALKLAFEKCS 163 Flavobacterium johnsoniae UW101
ZP_06142287  168 EEIGNAVINCFKMME 182 Ruminococcus flavefaciens FD-1
AFI92508     141 DDIGAAIDKAFSIST 155 Pectobacterium sp. SCC3193

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap