4G6U


Conserved Protein Domain Family
CDI_toxin_EC869_like
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cd13444: CDI_toxin_EC869_like 
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Zn-dependent DNAse of the contact-dependent growth inhibition (CDI) system of Escherichia coli EC869, and related proteins
CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring bacteria. This model represents the C-terminal toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered. A wide variety of C-terminal toxin domains appear to exist; this particular example from Escherichia coli EC869 and other bacteria appears to function as a Zn2+-dependent DNAse degrading the genome of target cells.
Links
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Statistics
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PSSM-Id: 259837
Aligned: 25 rows
Threshold Bit Score: 110.84
Created: 5-Apr-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: putative active site [active site], 4 residue positions
Conserved feature residue pattern:[EDQ] D S KClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                         #                              #          # #  
4G6U_A       147 ATATVNAse---iGXQWgq-----gnXKQGXPWEDYVGKsl----------paDARLPKNFKIFDYYDgaTKTATSVKSI 208 Escherichia col...
ZP_06603699    7 KIANRTVsi---gDNVW---------KKGPAKRGEIIDDa------------lGNNLGRNFPVIDKLE--NGVITSIKSM 60  Selenomonas nox...
ZP_02093564  246 LKLNTKVekiklrAEIW---------LEDKFERGIEIDGl------------rGNNLGHNFPVIDKFE--NRTITSVKSK 302 Parvimonas micr...
ZP_16425678  389 KIADRTVti---gGDVW---------KKGGAKRGQIIDGa------------lGNNLGRNFPKVDKLD--NGVAVSIKSI 442 Selenomonas nox...
YP_005147562 177 LLPGIKItqt-asACIWagedgvsslKGDSQENEQCVWNldkikrgreirrlqGANLPFNFPVISKYA--NGTATSIKSL 253 Clostridium sp....
ZP_08875141  113 ATPDITTr----gAVHWftp----dkNLRGESFEKYLEKtkyskk---ngyinLNDIQPKHKTFDSFNptTGHAVSIKTM 181 Verminephrobact...
YP_004449755 126 SLSQPNV------NPVWke-----tpTSRGNQIEASLINg------------fNDGWPNNFPVIDGYDaaTGTAISIKSI 182 Haliscomenobact...
YP_003475381 187 SKSDDNS------KNFW---------DWHNFKRGAYLREq------------nGGNLPHNYPVISRFK--SGEATMIKSI 237 Clostridiales g...
ZP_16968198  205 SKTQRQLes---lGIKSevkd--lgfQVDGTSPTGFDIDea-----------lKNNLGRTFKTFDEYDdvTKTATSVKSI 268 Fusobacterium n...
ZP_08647141   85 QMAGRPTiqw-kdGVQWvsqg--ngiQAQGNPFEVWDAQrlkseg--yfwladYNSDRSNWRTFDEWNrdSQTAISDKTI 159 Acetobacter tro...

Feature 1                                                                                        
4G6U_A       209 DTqtx----------akLANPNQVYSSIKGNIDAAaKFKEYALs-----------GRELTsSXISNREIQLAIPadt-tk 266 Escherichia col...
ZP_06603699   61 DLsa-----------psYQKSRDIYNKLKRDVDKLdEFKKQEWn-----------NKSIRsNDYSSKRLEIAIPdmeitv 118 Selenomonas nox...
ZP_02093564  303 DLla-----------ktYQNGKKLEYTIKSDINKLiKFKTKKWn-----------GHEVLtKDYSYKCLEVVVPnvtlse 360 Parvimonas micr...
ZP_16425678  443 KLsd-----------ktYETAKGIYNKLRRDVDALdEFTTGRRk-----------NNIVSpEDYSAKKLEIAVQdmkita 500 Selenomonas nox...
YP_005147562 254 NLde-----------iyYHNTDNLNNKIKEYIRKLqEFNGGKSg-----------SVTIDgSQIYRKELILVVPetditn 311 Clostridium sp....
ZP_08875141  182 DTlgls--------gsnPMKPWRASGYLRRYVDEAiEYKRVGQ------------PNGIEkGDIKSREIELAIPvgt-pv 240 Verminephrobact...
YP_004449755 183 DLna-----------ktYQNLAALENRLMDYFRKLrDFTREQRgli-------diGDPLR-TPINFKELVLAVPrqp-ta 242 Haliscomenobact...
YP_003475381 238 DLta-----------ptWQNPDNITEQASRMVKNLaGFNGTPElwg-------kdRISIRnGDIKSRKIIIVVPens-pp 298 Clostridiales g...
ZP_16968198  269 DLds-----------ktYTSGSGLSSKLNSNLKDIkDFTEYELg-----------DIYLSkDMIDKNVLKLVINnkplnk 326 Fusobacterium n...
ZP_08647141  160 DLnastykdrsnsappsAQFIKRIQGRILADVQQMiRYDEDSGtyryttnvptspTLSFAqNDIDHYVLDLGVPtep-td 238 Acetobacter tro...

Feature 1                                        
4G6U_A       267 TQWAEINRAIEYGKSQg------VKVTVTQVK 292 Escherichia coli O157:H7
ZP_06603699  119 EQRKGLEMIKEYTRNKg------IETTIIVVK 144 Selenomonas noxia ATCC 43541
ZP_02093564  361 SQINCINNAIEYAEKNn------IIVKIIVGG 386 Parvimonas micra ATCC 33270
ZP_16425678  501 EQQRGLEMVKEYAKEKg------IEITITLVK 526 Selenomonas noxia F0398
YP_005147562 312 AQLQTLNKCIDIAKEKg------ISLKIVKAY 337 Clostridium sp. BNL1100
ZP_08875141  241 KVREALDDVAKKALAQg------VVVNISVVV 266 Verminephrobacter sp. At4
YP_004449755 243 AEQAIINKVINSAMGLt------PPISIRVTV 268 Haliscomenobacter hydrossis DSM 1100
YP_003475381 299 QALAALRNALAAGAGQg------VFYEIIQSE 324 Clostridiales genomosp. BVAB3 str. UPII9-5
ZP_16968198  327 SQMENLKKVVDNATKEg------IKVEAIILK 352 Fusobacterium nucleatum subsp. animalis ATCC 51191
ZP_08647141  239 SQWKAICQALQKANDRvtgsgktIDFKVKDIG 270 Acetobacter tropicalis NBRC 101654

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