4G6V


Conserved Protein Domain Family
CDI_inhibitor_Bp1026b_like
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cd13443: CDI_inhibitor_Bp1026b_like 
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Inhibitor of the contact-dependent growth inhibition (CDI) system of Burkholderia pseudomallei 1026b, and related proteins
CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the inhibitor of the CdiA effector protein from Burkholderia pseudomallei 1026b (which is a tRNAse). CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered. The inhibitors are intracellular proteins that inactivate the toxin/effector protein.
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Statistics
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PSSM-Id: 259836
Aligned: 8 rows
Threshold Bit Score: 92.0683
Created: 5-Apr-2013
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDI toxin
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:CDI toxin binding surface [polypeptide binding site]
Evidence:
  • Structure:4G6V: CDI inhibitor from Burkholderia pseudomallei 1026b binds its cognate CDI toxin domain, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ### #                                     #  #                     ##  #        
4G6V_B          2 AIDLFCYLS---IDRGAAESDLNKIRSNh---sELFEGkFLISPVRDa-----------------dFSLKEIAAEHGLv- 57  Burkholderia p...
YP_001966344    2 AINLSCYTT---KEASEILAINTEIANNd---iLFIENrFLLYNPRFv-----------------nDIELEIASEFNFf- 57  Moraxella bovi...
AFG17287        2 AIDLFCYLS---IDRGAAESDLNKIRSNh---sELFEGkFLISPVRDa-----------------dFSLKEIAAEHGLv- 57  Burkholderia p...
jgi:YPTS_3640   2 SIDLRCYTTl-sVDELQKKLDVFLAKYPe----IFPEH-YILYKASTl-----------------gPFDKEISNEFGLd- 57  Yersinia pseud...
ZP_15543106     2 SIDIICYAS---INIDALKEKLDVVRESt---gHLFDGsYLMFEPHVilsrqqleliddrvekynqESKLLTAEAFGLke 75  Pectobacterium...
YP_002384027    2 SIDIRCYCT---TELSDLKNKLDCLRRKy---nHIFNDvYYMFEPEMvlshqdidiiddcikkynsESTILLAEEFGMmn 75  Escherichia fe...
ZP_16854060     3 IGDLRTKLDclmQKYSYIFNDVYHIFEQervlsHQDIN-AIDDRVEKyn----------------sESTLLIAEEFGMmn 65  Escherichia fe...
YP_006591581    2 STCFFFDSA---LRLDQTKELLSQAREKy---rDILRY-FWLSEVEEa-----------------rPPNIEDDAEYGFd- 56  Methylocystis ...

Feature 1              #   # #   ## #                   ##### #
4G6V_B         58 aESFFLVSLNDKn-sADLIPIVSKILVDGFngGAILILQDNEYRR 101 Burkholderia pseudomallei 1026a
YP_001966344   58 pKNKFLIALNDKd-ySSKIGEISDVFFEKYg-DDILILFENETKV 100 Moraxella bovis Epp63
AFG17287       58 aESFFLVSLNDKn-sADLIPIVSKILVDGFngGAILILQDNEYRR 101 Burkholderia pseudomallei
jgi:YPTS_3640  58 pESYFYISVSNKm-lEICTNEIARLVKDELgeDHVIVLHNGEDLI 101 Yersinia pseudotuberculosis PB1/+
ZP_15543106    76 pKSYFLVAVNDKsfpELNTSEIADVFRRELgeENVAILLNGEDLI 120 Pectobacterium wasabiae CFBP 3304
YP_002384027   76 pKSCFSIRVRDKtfsVMDTPELADLLRKELe-DSVLILLNYEVPL 119 Escherichia fergusonii ATCC 35469
ZP_16854060    66 pKSCFSIRVMDKtfsVLDTPELADLLRKELd-DGILILLNCETPI 109 Escherichia fergusonii B253
YP_006591581   57 pKCTFLIEWNKEr--SELLELIPAIFYEAFgkENILVRDNNYDVV 99  Methylocystis sp. SC2

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