1S2B,1S2K,2IFR


Conserved Protein Domain Family
Peptidase_G1
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cd13426: Peptidase_G1 
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Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin
Some members of this family had been classified earlier as carboxyl peptidases insensitive to pepstatin, and the family has also been called the eqolisin family, due to the fact that the conserved catalytic dyad of the family consists of a glutamate (E) and glutamine (Q) residue. The family is found in fungi and bacteria.
Links
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Statistics
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PSSM-Id: 240449
Aligned: 125 rows
Threshold Bit Score: 89.3111
Created: 17-Dec-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitepolypeptide
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1S2B: the active site of Scytalidium lignicolum scytalidocarboxyl peptidase B (SCP-B), formerly known as scytalidopepsin B, coordinates three water molecules, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      # 
1S2B_A         3 ESNWGGAILIGs------------DFDTVSATANVP--SASGg----------------------------sSAAGTAWV 40  Scytalidium lig...
EGS20174      53 SNNWCGSVNYApi---------grQIRLVHGYFQHPvcEIRNgmk-------------------------tfPQAVAAWV 98  Chaetomium ther...
Q2HET2        21 SSNWCGASQHApp---------aeKITNAIGYFTVP--DLTLrpg------------------------ipaPQFAAAWV 65  Chaetomium glob...
XP_003352979  82 STNWCGSVRTTts---------tnQIKLIHGSFQHP--TCTQrpgi-----------------------ttyPQAAAAWI 127 Sordaria macros...
EGS20173      46 TATRKGVPIPAseiklkpletyqlGNPPSKATRLNP--RANPianssnwcg------------svntapsgkSIAVAAWV 111 Chaetomium ther...
XP_001903993  75 SANWCGAVNHSpt---------tnKIKSIHSFWQVP--GCTKrtg------------------------qtyPQAAAVWI 119 Podospora anser...
XP_003352581  84 GPSWYGASKQLvs---------peELSSVYGVFTVP--NLKLrxxxxxxxxxxxxxxxxxxxxxxxxxxlkaPQNAAAWV 152 Sordaria macros...
EJT75707      72 MENQSGVTKAGt------------LIGNVAGTVTVP--EFRTcdd-------------------------gfTSGMYLAI 112 Gaeumannomyces ...
XP_003656949  77 SSNWCGASQHVsq---------adGIGSVFGYFTAP--DGTLrpg------------------------vppPQFVSAWV 121 Thielavia terre...
EJP64313      83 FSNWCGAANLSppg--------ggAWSRVSGAWTVP--EISLranq----------------------sdddQPSLVQWI 130 Beauveria bassi...

Feature 1                     #                             #                                    
1S2B_A        41 GIDGdt-cqTAILQTGFDWyg--------------dgTYDAWYEWypevsddfsgITISEGDSIQMSVTATS-DTSGSAT 104 Scytalidium lig...
EGS20174      99 GIDGdt-wtDSLLQAGTVCkidns---------sgvvTNEAWWQWvpsgaytistLPVAEDDWFEVTINTTS-PSSGEIT 167 Chaetomium ther...
Q2HET2        66 GIDGae-cnSTLLQAGFTTvvns----------nggqSASAWWEWypeaaysidgLKVKPGDWVSVNITARD-ETSGTVV 133 Chaetomium glob...
XP_003352979 128 GIDGds-wtTALLQAGTVCkinns---------tgivENEVWWQWvpsgaytianIPVFAGDWFDITINTTS-ATAANIK 196 Sordaria macros...
EGS20173     112 GIDGds-wtSALLQAGSVC------------------ERSVWVPLgaya---itsLSISPGQWLEVTINATS-TTSAQIS 168 Chaetomium ther...
XP_001903993 120 GIDGnt-wpSALLQSGTVCkidtstsatsisllihcsRHEAWWQWvpdt---aftISTMPPFFLPSFLPHDQnQHLFPSK 195 Podospora anser...
XP_003352581 153 GVDGds-cnRALLQVGVTTlins----------ngqqITEAWWQWwpsaaysitsFPTVPGDWLAVNITITS-STFASIK 220 Sordaria macros...
EJT75707     113 RIDGveprwQDPVAVGIGHl-----------------ASKTGSNGdlra--nnfrADWRWGDSGGSENLVALtPFGLNGT 173 Gaeumannomyces ...
XP_003656949 122 GIDGae-cnTALLQAGVTTivns----------nggqSISAWWEWypdnsytidgLKVEPGDWMWINITTTS-ESSAILE 189 Thielavia terre...
EJP64313     131 GIDGdgcqsGGLIQGGSGSqids----------ngeqENYAWFEFvpapl-rtftMNVGAGDQMSGLVTADS-SRSGNVT 198 Beauveria bassi...

Feature 1                                       #  #                                             
1S2B_A       105 LENLTTGQKVSKSFSnessgsLCRTNAEFIIEDFEecnsngsdcefvPFASFSp--AVEFTDCSVTsdges--vsldDAQ 180 Scytalidium lig...
EGS20174     168 ITNLSQRYTYSVTLSgg--ptLARVDADWVVERPYfgk------tlsGFATFT---DVWFEDTYAEllpgtgtigvlGAN 236 Chaetomium ther...
Q2HET2       134 ITNSEQGTAVTMEINng--pkLCRRDVEWIVEDFYqsg------eqvELAHFS---DLWFVDSVATtasgk-lvgfdGAA 201 Chaetomium glob...
XP_003352979 197 IINTSRGYTQSFNIYtg--atLARVDADWVVERPYygt------alaGFAQFT---QVWFQNAYATltsgt-nlgitGAK 264 Sordaria macros...
EGS20173     169 LMNLHTGVNYNVILTng--ptLARVNANWVVERPYygs------tlvTMPAFS---DVWFTYASASltpsg-slgilGAK 236 Chaetomium ther...
XP_001903993 196 FDNVSQDEQVIVNVTsg--ptLARKDADWVVERPYyg---------sSLAGFPrfdTTWFEDSYATrttgg-nlgilGAT 263 Podospora anser...
XP_003352581 221 IINTQRGYTMSFNVFdg--vaLCRKNAAWIVEDYYdga------ggiNMAGFN---NVWFEYTAATtvagt-klgvdGGV 288 Sordaria macros...
EJT75707     174 IKNLNTGQEVYRILSsp--ggYCGSTANWIGGSYTraa------rpiPFTEYLg--AVTWTDVRAAtavge-tlnleGAE 242 Gaeumannomyces ...
XP_003656949 190 VTNPQQEYTMTLDISng--pkLCRVDAEWIVEDFYdan------gqvAFANFS---DLWFVQSGAQsiggr-sigldGAA 257 Thielavia terre...
EJP64313     199 INNVSTGQSMHFYFSdgg-agLCGTSAEWILEDLTslps----rnlePFADFP---DTHFTDCRAStsagq--sagpGTN 268 Beauveria bassi...

Feature 1                                              
1S2B_A       181 ITQVIinn-----------qdVTDCSVSg-tTVSCSYV 206 Scytalidium lignicola
EGS20174     237 QYQIPg--------------mCTSMEWDd--RHLVSWS 258 Chaetomium thermophilum var. thermophilum DSM 1495
Q2HET2       202 MVHLQnetg---------qvlCSAERYDntnVVLVSHL 230 Chaetomium globosum CBS 148.51
XP_003352979 265 QYQIPsp------------ngCASAEFDn-aKLYASVA 289 Sordaria macrospora k-hell
EGS20173     237 QYQIPg--------------fCGSEEYDn--TAQVSYV 258 Chaetomium thermophilum var. thermophilum DSM 1495
XP_001903993 264 QYQIPs--------------lCNSTEYDn--ANSVSFS 285 Podospora anserina DSM 980
XP_003352581 289 FWNIQnstg---------qlkCTSQKYDn-sNLVIRSV 316 Sordaria macrospora k-hell
EJT75707     243 TIDLDqswkldpslgpiqgglQTDCNIFgasSFICKRL 280 Gaeumannomyces graminis var. tritici R3-111a-1
XP_003656949 258 MVHIQaddg---------tilCSAEPYDn-aSFVISSH 285 Thielavia terrestris NRRL 8126
EJP64313     269 NVNIAqng-----------raLCTGQISg-sSVYVHST 294 Beauveria bassiana ARSEF 2860

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