Conserved Protein Domain Family
PH-GRAM1_TCB1D8_TCB1D9_family
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cd13217: PH-GRAM1_TCB1D8_TCB1D9_family 
TCB1D8 and TCB1D9 family Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
TBC1D8, TBC1D8B, TBC1D9 and TBC1D9B may act as a GTPase-activating proteins for Rab family protein(s). They all contain an N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the first repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.
Links
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Statistics
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PSSM-Id: 275404
Aligned: 8 rows
Threshold Bit Score: 136.798
Created: 1-Mar-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002716991  157 EEKLVNYYSCSYWKg--KVPRQGWMYLSINHLCFYSFLMGrEAKLVIRWVDI---------------TQLEKNAt---lL 216  rabbit
XP_001507498   56 AEKLITYYSCCCWKg--RVPRQGWLYLSINHLCFYSFFLGkELKLLIPWADV---------------QKLERTSn---vF 115  platypus
XP_001513041  181 QEKLVTYYSCSYWRg--RVPCQGWLYLSTNFLSFYSFLLGsEIKLVISWDAI---------------SKLEKTSn---aI 240  platypus
XP_001648031  148 DEKLVSYYSCSYIK---RVPRQGQMYLSLNHLCFYSYIFGaESKLRFRYNELt-------------dIKKSGTMi---tI 208  yellow fever ...
NP_649305     147 EERLVISYSATYVKn--KIPRQGQLYISLNHVCFYSYMLGqEIKRIIRFAEL---------------EDISRNAn---tI 206  fruit fly
XP_001191383  136 PTETKEDYSCSYWKg--RVPRQGWLYLSVDHFCFYSFLMGtESRLQIRWTEVtatgpdeeskrfkaaSDKWRRLf---nI 210  purple urchin
EGD78656      145 EERLVTSCLCNYWSnkhTMPKKGWLYVSVNHFNFYSFILGeEVRLSIPWTHVvg------------vVEVTRFMapairI 212  Salpingoeca s...
XP_003384261  154 EEKLVNYYACSYWKg--NFPRQGWLYLSINHLCFYSFLMGsVTTVIIRWSEV---------------KDITRKSi---kL 213  Amphimedon qu...

XP_002716991  217 LPDVIKVSTrssehFFSVFLNInet--------fkLMEQLANIAMRQ 255  rabbit
XP_001507498  116 MTDTIRVTTqskerDFSMFLNLdev--------fkIMEQLADVTLRR 154  platypus
XP_001513041  241 LTESIHVCTrgedhYFSMFLHInet--------flLMEQLANYAVRR 279  platypus
XP_001648031  209 KTSQNKEYTfaflyPLGEVYNLieql------skiTMQKLIQDPDRP 249  yellow fever mosquito
NP_649305     207 YLKTTNNMTy----NFTMLFNAsdahllieqlnkmAIQQLIHDPDSP 249  fruit fly
XP_001191383  211 PEDEKLVNCk----PTGDSISIa-----------sSNEGSMTIPHRT 242  purple urchin
EGD78656      213 TTSTHKHVLss-vpDREMMLQLfyql------takAMSRLLEISDDA 252  Salpingoeca sp. ATCC50818
XP_003384261  214 GEAIIVENDrnkehYFSMFVNIset--------hsLMEQLAQVAITE 252  Amphimedon queenslandica
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