2KZU


Conserved Protein Domain Family
DAXX_helical_bundle
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cd13151: DAXX_helical_bundle 
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Helical bundle domain of the death-domain associated protein (DAXX).
DAXX is a nuclear protein that modulates transcription of various genes and is involved in cell death and/or the suppression of growth. DAXX is also a histone chaperone conserved in Metazoa that acts specifically on histone H3.3. This alignment models the N-terminal helical bundle domain of DAXX, which was shown to interact with the tumor suppressor Ras-association domain family 1C (RASSF1C).
Links
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Statistics
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PSSM-Id: 240522
Aligned: 6 rows
Threshold Bit Score: 82.9245
Created: 1-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Rassf1C
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:Rassf1C interface [polypeptide binding site]
Evidence:
  • Structure:2KZU: the helical bundle domain from human DAXX binds a peptide from the Ras association (RalGDS/AF-6) domain family 1, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  # ##  ##  #                             ## ## ##  ##  #
2KZU_A          7 KCYKLENEKLFEEFLELCKMQTa-dHPEVVPFLYNRQQRAHSLflaSAEFCNILSRVLSRARSRPAKLYVYINELCTVLK 85   human
AAH79997       50 GSMSTDNAKLFEEFVDYCTSLTq-eHPEVITFLRGRLSKASPTflsSVEFHNILSRCLTRVQKKRTKVYVYINELCTVLK 128  African clawe...
AAI33997       62 HVLKVENEKLFNEFVEHCSKHSq-eHPEVMTYLQTRYSKALPTfltSVEFRNTLGRCLTRAQANAGKTFVYINELCTVLK 140  zebrafish
XP_001917892    8 GEGRLERPLLSIIVLDDDDEDEaaaQPGPSHPPPNPASPQAEA---PGSSQNREKILIAVKASRPAKLYVYINELCTVLK 84   horse
GAA30833       27 EIHIIGKIKQFEESLQKYLPKS---DREVISVLRRKYQRTNTEfrhSKQCKSVLRQCLQRIAARPTRVYMILNDLKTTLK 103  Clonorchis si...
CCD74847     1055 LVNLAGRVHSFTKQIRKYLSDS---DEQIVNILRKKFLQTTYEfqkAEVSKPIFDKCIAEIAFNPDRIYVILNDLKTTFK 1131 Schistosoma m...

Feature 1             #    
2KZU_A         86 AHSAKKKLN 94   human
AAH79997      129 ANSSKRKIN 137  African clawed frog
AAI33997      141 QHTPRKRSS 149  zebrafish
XP_001917892   85 AHSAKKKVN 93   horse
GAA30833      104 LQTTGISLN 112  Clonorchis sinensis
CCD74847     1132 LHTPKIDKK 1140 Schistosoma mansoni

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