Conserved Protein Domain Family
MATE_NorM_like

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cd13137: MATE_NorM_like 
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM
The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Statistics
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PSSM-Id: 240542
Aligned: 98 rows
Threshold Bit Score: 248.966
Created: 31-May-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9WZS2    20 KELIKLALPAMGENVLQMLFGMADTAFLGHYSWKAMSGVGLSNQVFWVVQVVLIAASMGATVTIANAIGAgnRKAVRSLA 99  Thermotoga maritima...
ADY12917  10 RQIRAMSLPTMYGMLFTALYDMVDMFWIGMLDKEAVAAITIYLTLFLALEILNEVVGTSSVSLLSRSWGSgdIELTRRIG 89  Spirochaeta sp. Buddy
ADK82490  11 KHILSMSLPTMSGLMLQGLYDIVDMIWIGHISYQAVAAITIFASIFWIFEVLNEIIGMSSVSLISQSYGAgdMKRTAVAA 90  Spirochaeta smaragd...
ABV33691  12 KNLFYMALPTMGGFALQALYDVVDMFWIGRISAKAIAGVAVFSTVFWLIEVLNEIIGVSSISLISQNYGAkdYERTNRVI 91  Thermotoga lettinga...
AAS10788  25 KNLWKLAYPTMISAGLQNFYDIVDMVWVGQISKTALSGVTLFSSIYMLFTILNEVAGASSVSMISQNYGRgdMEKTQRIA 104 Treponema denticola...
AEV28622  14 KEIFKLSLPTMSGSLFQAFYDIVDMVWIGMINTQAVAAATIFVTLFWVIEILNEVVGTSSISMLSQYYGSgdLEKTRDAS 93  Spirochaeta sp. Grapes
ABR31201  13 KQIFLMGLPTAIGFSFQMFYDIIDIFWIGKISSQAIAGVGIFTTIFWVVEALNEIIGVSSISLISQSFGKkdFEKTNMAI 92  Thermosipho melanes...
ACI17510   8 KVIWSMSLPNMLGSLLSNALPAIELALIADLGTNAIAAVGIVGMLVSLIYVYNEVWGTGSVIVMANYLGKkeYEKARLAL 87  Coprothermobacter p...
AFK05765  12 KNLLVMSVPTMIGFSAQMVYDIVDIFWIGRISGEAIAGVTIFTTLFWIVDILNSIIGQSSVSLISQSFGKkdLEGTNRAI 91  Thermotogales bacte...
AFG34376  31 KELFRLSLPTMLGFAIQSLYDIVDMFWIGKISYKAIAGVVIFSTIFWLVEILNEIIGTSSVSLISQAYGKgdLKLTSRII 110 Fervidobacterium pe...
Q9WZS2   100 WNSVFLAIFTGVILTAL-TPLSDVLINIFPnlEGEIESSAKEYLKVILSGSMGFSIMAVFSAMLRGAGDTRTPMIVTGLT 178 Thermotoga maritima...
ADY12917  90 EQTFVFKALLGSLGALVlILILPFFYRLYTd-DAKVIFHGMQYGYLRSIFVPIFFSSYTVNTILRSTGDAKTPMLLLLAS 168 Spirochaeta sp. Buddy
ADK82490  91 EQTITCKFLIASLAAILlCIFLKPMLHLFTd-DQLVTEYAKDYGYLRAATIPIFFSSFSVNTIFRCTGDAKTPMFLLIGS 169 Spirochaeta smaragd...
ABV33691  92 EQTIVFKAFVALIASLLlVLFLKPLMSFFSk-DREVIQAGLEYGYWRSFFMPIFFATYSTYTAQRTTGESRLPMIIMGAS 170 Thermotoga lettinga...
AAS10788 105 EQTISFKVVLAIMSAFLlAIFLKPILWFFLp-DQEVLNSALEYGWLRIFFIPVMFSSYSVNTIFRCTGDAKTPLHIMIIS 183 Treponema denticola...
AEV28622  94 EQTFVFKALLGVIGAIImMILLPPFFHLYSs-DPKVITYGLRYGYIRIVFLPVFFSSFTVNTIFRCTGDAKTPMRLLIIS 172 Spirochaeta sp. Grapes
ABR31201  93 EQTITFKFLVALIGSLIlIVFLKPLMSLFA--GTQIVFYGLEYGYLRIFFLPIMFSSFSVNTALRSIGDSKTPMLLMILS 170 Thermosipho melanes...
ACI17510  88 KETTYGKFFGALILVLLcLPFLEPLLRVLGa-KPQIMLHAKGYALPYLLGIPFSMAGYSSYTFFRATGQTIWAMWFMLLQ 166 Coprothermobacter p...
AFK05765  92 EQTITFKFIVALISALLvAAFLKPSLGFFSn-DPTVITAALDYGYIRLFFLPMMFSSYSVNTALRCIGDAKSPMYIMMMA 170 Thermotogales bacte...
AFG34376 111 EQTLIFKAMVALIASGIlLVFFKPIVSFFSs-DIEVVNSAIHYGYIRIFFMPIFFMTYSTFTALRNIGCASLATLTMATG 189 Fervidobacterium pe...
Q9WZS2   179 NFLNIFLDYAMIFGkf-----gfPEMGVRGAAVATILSRFVGAGILTYVIFKREEfqlrkglv--ppkwssqKEILRVGF 251 Thermotoga maritima...
ADY12917 169 AVLNMVLDPIFMFStipgtsiagLGWGMFGAAFATCISYAFAFVVGFWYLQSGKApltirvkgllhldwaidKKLLIIGL 248 Spirochaeta sp. Buddy
ADK82490 170 AVINIILDPILMFDsipgtslpgAGLGMFGAALATVLANMVALGIGMLLLLCGKSgvrispkglfrlvpvmdKKLLTIGL 249 Spirochaeta smaragd...
ABV33691 171 AVLNIILDPVFMFEkipginmkgFGLGVSGAAVATVISTCVAFIWGFGLLLKGRGeikisirglfrldreidKKLMTIGL 250 Thermotoga lettinga...
AAS10788 184 TIINLVLDPVFMFDiipgtnipgLGMGVFGAALATVTARTISFLYGFLILLSGRRkvkisfkglfkldkkidTDLLLIGL 263 Treponema denticola...
AEV28622 173 SLLNLLLDPLLMFDvipgtsihgLGWGMVGAAVATVISVTFSFTVGFFLLVTGRApikirskgifhldwavdRKLLTIGL 252 Spirochaeta sp. Grapes
ABR31201 171 SVVNIILDPILMFDklpivnirgFNMGVKGAALATIIAQSLAFLIGFYVLFSGREnikpsfkrlfrlifeldKKLILIGL 250 Thermosipho melanes...
ACI17510 167 TALNIALDFFLILGfw-----ifPKLNLAGAGWAFLISWVVSDIAAFMFIATPRYelptnisr-hvrftevgAEVFRVGF 240 Coprothermobacter p...
AFK05765 171 SALNVVLDPILMFShipgtsipgFGLGVFGAAVATVIAQTASFLLGFFILFSGKEgvkpklsrlfrldrhidRKLLTIGL 250 Thermotogales bacte...
AFG34376 190 TIVNIILDPIFIFDklplfnitgFGLGVSGAAWATVISTFIPLIWGLYLLFRGIEgvkislkglllldkkidTKLITIGL 269 Fervidobacterium pe...
Q9WZS2   252 PTAIENFVFSTGVLMFANILLIAGAEAYAGHRIGiNVESLSFMPAFGISVAITTLVGRYNGMGNkEHVLGVIRQGWILSL 331 Thermotoga maritima...
ADY12917 249 PSGINMLLRSLITIIFLKLVALYGTTAIAALGIAnRIYQFCGMPSNGLSMGSGILVGQRLGAKQyKQAKEVTLLSCFNGL 328 Spirochaeta sp. Buddy
ADK82490 250 PSGFEMLFRNTANTVFIKMVGVYGTAAVALIGVGlRIYSFIFMPIMGIVMGSGTIAGQNLGANQiDRSRATAWYSSLIGS 329 Spirochaeta smaragd...
ABV33691 251 PSGVEVFMRSLSNAVLMKFLAAYGSTTLAVVGVVsRLMGLAFIPLMGFSMGASTIIGQNLGANKiERAEKTVLLAAIYSS 330 Thermotoga lettinga...
AAS10788 264 PSGINSLVRSFAQVTIMKFVTVYGADAVALAGVGgKLSQFAFMPIFGFNMGGATLVGQSLGRDNvKEAKLTSKINAFMSA 343 Treponema denticola...
AEV28622 253 PSGLNLLLRNVVTFVILKLVSYYGTGAIAVLGIAnRIYQFGAMPSSGLGMGSGILVGQALGSEEvLKSRHIVFLTSANGL 332 Spirochaeta sp. Grapes
ABR31201 251 PNGFEVFMRQLSAVVTLYFVAIYGEANITAYTIGgRIFGFVFMPLWGFLMGGSAIIGQNLGAEKiSRAEKIAKISGWFSV 330 Thermosipho melanes...
ACI17510 241 YAGLSNLSTVAVSVITQRIINAVSIPVFAAYQVFnRIVQIPNTVVSSISLMSTPIMAQNVGAKLhDRVKAFVDYCLEIGV 320 Coprothermobacter p...
AFK05765 251 PTGLEGFFRNLAAVVVLKFVALYGTTAVAAVGVTgRLFGLAFMPLVGLNMGGSAMVGQNLGADDvGRARATAKTAGLIGF 330 Thermotogales bacte...
AFG34376 270 PSGVEMLLRNLSYTVLIKISSLFGPEYVTVFGIIeRMFGFAVIPIFGLSMGASTLVGFQLGKNNeEGAKKATILATLYSV 349 Fervidobacterium pe...
Q9WZS2   332 LFQVTVGIIIFLFPEPLIRIF-TSDPQIIe-iSKLPVKIIGLFQFFLAIDSTMNGALRGTGnTLPPMIItFISIWTARLP 409 Thermotoga maritima...
ADY12917 329 LFSLPFILLLLLAPGPLISLF-LGGGVISs-eASALLRVYALCLVFLAISGGLGSAFFGSGhTRPILYTsLISGWMVQLP 406 Spirochaeta sp. Buddy
ADK82490 330 LLTAVLITLVLLRPQVVLGWF-LTDLDEIr-qGVGMLSIVLPSLIIAAFSLGWSSVFSGSGyTMPFLISsFVAKWVVMIP 407 Spirochaeta smaragd...
ABV33691 331 LFVLGFVVLANIFPETIMNFF-VHEPEVIa-eGVSAVRIGSWSILIAAFAVALMSSFFGAGyTLPAMLSsIIGRWFAQLP 408 Thermotoga lettinga...
AAS10788 344 SVVGIFAVIIMGMPQTFLRFFfPNDPSMLl-qGSLMLRIFYPSFIILSMGLGLAVVFSGSGhTRPILYStLGSRWFVQIP 422 Treponema denticola...
AEV28622 333 VFSLLSSVAFFIFPRQLLSLF-LGKGDINlfdGIGLMYVYGLSLMVLSLMSGLGAAFFGSGkTHPILYAsLISQWCFQVP 411 Spirochaeta sp. Grapes
ABR31201 331 VFTAIFLIFILIYAPSLISIF-SKEENIIe-sGALFLRYSTLGLLFLAYAIGLSIVFPGSGyNLPYLFMsLGSRWFVQIP 408 Thermosipho melanes...
ACI17510 321 YLLGVFAIICLIFPGSLLSLFrVKDPTLVp-lAVLALRIMAFVPLMSYTTSIFISYFQAYNnTKLPFILnSLAQWLFYAP 399 Coprothermobacter p...
AFK05765 331 FIMFFFALIAFFGGEIVIGIF-NDDPEIIs-yGASFLKYGSLGISVLAYGFGLSSVFGGSGyNFPFVVGsVVSRWLIQVP 408 Thermotogales bacte...
AFG34376 350 IIVSLLLVLILLFRESVFTLF-TSNKNVIe-iGARSIPYVVFALFMISFSAGLSSAFFGSGkTSIPMIAgILSRWGVMVP 427 Fervidobacterium pe...
Q9WZS2   410 VAFVMVKyfqLGLLGAWIGMIADIIFRSTLKLLFFLSGKWE 450 Thermotoga maritima MSB8
ADY12917 407 YALLVVLvfkLPLPWLWSAYLIGDSLDCLLRYRYFRLGDWK 447 Spirochaeta sp. Buddy
ADK82490 408 YSAVVVYrfhASLTYVWISFVLSEIAEMIILGRFFHKGAWK 448 Spirochaeta smaragdinae DSM 11293
ABV33691 409 YVAIVTLlfkLPSLYVWFSFIIAEIAELAYAAIVFSKGKWK 449 Thermotoga lettingae TMO
AAS10788 423 FLFLVVNilhLPLFAVWTSYIFSEAAEFMVILYHYRKGAWC 463 Treponema denticola ATCC 35405
AEV28622 412 YALFVTLvlhLPVTYLWVAYFIGDFIECVGMYIYYRKGEWT 452 Spirochaeta sp. Grapes
ABR31201 409 LMYIFAIvfrLPVIWLWLSFAFGDISEFIIAIYFYKKGGWK 449 Thermosipho melanesiensis BI429
ACI17510 400 MLYLLLMvlsVSPSTAFWVSSANTFLVLVLHWYYYRAHRKL 440 Coprothermobacter proteolyticus DSM 5265
AFK05765 409 MLIVFVAfmkASIVWVWLSYVFSDIAEATVMIFYYLRGKWE 449 Thermotogales bacterium mesG1.Ag.4.2
AFG34376 428 LVLISTYvlrLGPIGLWMAFPVTEFVEVLVMSIAFLKSDWY 468 Fervidobacterium pennivorans DSM 9078
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