2LUA


Conserved Protein Domain Family
MSL2_CXC
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cd13122: MSL2_CXC 
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DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins
The CXC domain of Drosophila melanogaster MSL2 forms a Zn(3)Cys(9) cluster and is involved in recruiting members of the dosage compensation complex (DCC) to sites on the X chromosome.
Links
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Statistics
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PSSM-Id: 240555
Aligned: 15 rows
Threshold Bit Score: 54.7038
Created: 1-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 9 residue positions
Conserved feature residue pattern:C C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Zn(3)Cys(9) cluster
  • Structure:2LUA: Drosophila melanogaster MSL2 CXC domain binds 3 zinc ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # #             #    # #      #  # #  #       
2LUA_A         1 SPPKPKCRCGISGSSn--TLTTCRNSRCPCYKSYNSCAGCHCVGCKNPHKED 50   fruit fly
XP_796886    365 LPVIEGCRCGTWGKSp--GANTCKGNRCPCFMTEKGCLRCKCRGCRNPFIVP 414  Strongylocentrotus purpuratus
EJY57990     203 LLKRRGCRCGNATATp--GKLTCCGQRCPCYVDSKSCVDCKCRGCRNPHRAD 252  Aedes aegypti
EFX69504     227 KLKRKGCRCGNATSSp--GKLTCCGQRCPCYVEAKACTDCRCRGCRNPHIPG 276  Daphnia pulex
NP_001156770 415 TQEKKGCKCGRATQNp--SVLTCRGQRCPCYSNRKACLDCICRGCQNSYMAN 464  Danio rerio
XP_002735693 279 KSRKKGCRCGTCNMNvppGVFTCHGKRCPCYVSFRGCSHCRCRGCKNPYTPS 330  Saccoglossus kowalevskii
XP_002067974 451 QKQRKVCGCGQKVGQk--KRNVCRSNRCYCYSNGYSCSDCNCQGCKNPLKSD 500  Drosophila willistoni
XP_002064454 754 PKQRKHCRCGISGPS---TPKTCRNNRCWCYINGNSCTDCSCQGCNNPHKQD 802  Drosophila willistoni
AAC64547     517 TRMSHICRCGTTSAP---GRATCRNSRCTCYVAGKSCVDCKCIGCKNPHQDA 565  Drosophila virilis
XP_002595199 195 PPEKRSCRCGTFCEP---SELTCHRQRCPCYSNQLSCTGCRCRGCKNPYKDD 243  Branchiostoma floridae

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