2KGU,1AGG,1IVA,1OMB


Conserved Protein Domain Family
Spider_toxin
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cd12960: Spider_toxin 
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Spider neurotoxins including agatoxin, purotoxin and ctenitoxin
This domain family contains spider toxins that include the omega-Aga-IVB, a P-type calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta, as well as purotoxin-1 (PT1), a spider peptide venom of the Central Asian spider Geolycosa sp., which specifically exerts inhibitory action on P2X3 purinoreceptors at nanomolar concentrations. These spider toxins, which are ion channel blockers, share a common structural motif composed of a triple-stranded antiparallel beta-sheet, stabilized by internal disulfide bonds known as cystine knots.
Links
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Statistics
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PSSM-Id: 240575
Aligned: 23 rows
Threshold Bit Score: 27.3634
Created: 1-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PrincipalExtra
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Principal Structural Motif (PSM)
Evidence:
  • Comment:Principal Structural Motif (PSM) for spider toxins: CXXXXXXC-----CC, where the CC occurs at a distance of 5-10 amino acid residues from 2nd Cys residue
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #      #      ##                          
2KGU_A         2 YCAEKGIRCd--dIHCCtgLKCKCna-------sgYNCVCRKK 35  Geolycosa
Q5Y4U4        49 QCIGRSCTCdtssTSCCpyAACRCnl-------wkTSCKCQRT 84  Agelena orientalis
XP_001950560  81 YCVPRGENCdhrpKYCCnsSSCRCnl-------wgVNCKCQRM 116 pea aphid
B6DD06        27 VCIPLNGECskspNKCCdnINCDCylrfekgvqtgRPCFCTEK 69  Lycosa singoriensis
EFX89740      28 SCIRRGGSCdhrrNDCCfsSSCRCnl-------wgSNCRCHRA 63  common water flea
XP_003738110 140 SCIRRGGSCdarpSDCCyhSSCRCnl-------wgTNCRCMRM 175 western predatory mite
P86269         2 YCAEKGIRCd--dIHCCtgLKCKCna-------sgYNCVCRKK 35  Geolycosa sp. A267TDLS2-KZARNA
AAU87899      38 YCAEKGIKCh--nIHCCsgLTCKC-----------KGSSCVCR 67  Agelena orientalis
P84015         2 FCAQKGIKCh--dIHCC--TNLKCvr-------egSNRVCRKA 33  Brazilian armed spider
P11057         1 ECVPENGHCrdwyDECCegFYCSCrq--------pPKCICRNN 35  Agelenopsis aperta

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