Conserved Protein Domain Family
SPRY_BSPRY
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cd12904: SPRY_BSPRY 
SPRY domain in Ro-Ret family
This domain, named BSPRY, has been identified in the Ro-Ret family, since the protein is composed of a B-box, an alpha-helical coiled coil and a SPRY domain. The gene for BSPRY resides on human chromosome 9 and is specifically expressed in testis. The function of BSPRY is not known, but several related proteins of the RING-Box-coiled-coil (RBCC) family have been implicated in cell transformation.
Links
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Statistics
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PSSM-Id: 293961
Aligned: 9 rows
Threshold Bit Score: 317.825
Created: 22-Jun-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5W0U4       232 IRIDERTVSPfLQLSDDRkTLTFSTKKSKa-CADGPERFDHWPNALAATSFQnGLHAWMVNVQNscaYKVGVASGHLpRK 310 human
AAI15358     138 MQFEKQTVSPlLSLSNDQrTITFQPKRQRqlPPYDSERFDNLPNALCSPSMSsGTHSWVVDVGTsgaFKVGICYASIeRK 217 zebrafish
CAF89075      57 LKFDERTVSPlLSLSDDFcTVTFLHKKPRqaVRYDPARFDCWPNVLGSLSLSsGTHSWVVDVGQsdaFKVGVCYASLeRK 136 spotted green p...
XP_415546    184 ISIDEKTVSPyLSLSEDKkTLTFSPKKAKl-DLDGPERFDHWPNALATAAFHtGLHAWKVSVEKscaYKLGVCYGSLpRK 262 chicken
XP_007665507 204 VHVDEKTISPfLTLSEDRrTLTFNPKKTKv-YPDGPERFDHWPNALASSSYRsGLHAWLVSVGQscaYKVGVSSGLLpRK 282 platypus
XP_007064584 165 VRVDEKTISPlLALSEDKkTLAFSSKKAKt-YPDCPERFDHWPNALGTKAFHkGTHAWRISVGKscaYKLGIAYGSLeRK 243 green sea turtle
XP_007254084 300 LHFDQRSVSPlLSLSPDGrTLTFLPKRQRqsPPYDPERFDSWPNAVCSNPITsGQHSWALDVGTsgaFKVGVCYASMqRK 379 Mexican tetra
CDR01107      58 LTFDERTVSSlLSLSEDLcTLTFLPKRSRqsPPYDPARFDSWPNALGTLSISsGTHSWVMDVGEsgaFKVGVCYTSMgRK 137 rainbow trout
XP_007429050 161 IRIDEKTVGPfLALSDDRrTLTFSPKAAQrpDLDDPARFDHWPNALAGESFRaGIHAWRVNVSKscaYKLGISYNSLqRK 240 Burmese python

Q5W0U4       311 GSGSDCRLGHNAFSWVFSRYDqeFRFSHNGQhEPLGLLRGpaQLGVVLDLqVQELLFYEPAsGTVLCAHHVSFpgPLFPV 390 human
AAI15358     218 GSGNEARLGYNTNSWVLSHYDgdLSFCHNGCsVAISLAKKlkRVGLLLDWpSQTLLFYDPEsMSVLHVARYAFrePLLAA 297 zebrafish
CAF89075     137 GSGNEARLGHNSQSWVLSRFAgdYSFFHAGQkVPLQVVKGpqRIGVLLDWpSQTLLFYEADsGAVLYTLTHPFssPLLPA 216 spotted green p...
XP_415546    263 GPGNEVRLGFNAASWVFSRYDkeFRFLHAGQpQPVELLRApaEIGVLVDFaGGEVLFYDPDsCTILFSHREAFaaPLYPV 342 chicken
XP_007665507 283 GSGNDTRLGHNAFSWVFSRYDkeFRFSHDGQhKPLELLQCpaRVGVLLDLaAGELLFYEPGsCAILHSHRAPLagPLFPV 362 platypus
XP_007064584 244 GPGSAARLGYNPFSWVFSRYDkeFCFSHNGHhQAVELVRCpiQVGVLVDLdGGEVLFYDPTaCVILHSHREAFtaPIYPV 323 green sea turtle
XP_007254084 380 GTGNDARLGYNAKSWVLSHYDgdFSFCHNGRnISVAVVKRpsKVAMLLDWsMQTLLFYDPDtMSILHTVRQAFtePVLPT 459 Mexican tetra
CDR01107     138 GSGNNSRLGYNGQSWVLSKYDgdFSFCHAGKnTPLHVIHKpkSLGLLLDWpSQTLVFYDPDsSAVLHSVRHTFsgPLLPA 217 rainbow trout
XP_007429050 241 GAGPEARLGYNLFSWIFSRYDreFQFSHNDQhLTMKLLKCpaEIGVLVDLdKGELVFYDPDsCTVLHMHQETFaaPVYPV 320 Burmese python

Q5W0U4       391 FAVaDQTISIV 401 human
AAI15358     298 CAVaDQSISIV 308 zebrafish
CAF89075     217 CAVsDCSVTIL 227 spotted green pufferfish
XP_415546    343 FAVaHQSISLS 353 chicken
XP_007665507 363 FAVaDQSISIV 373 platypus
XP_007064584 324 FAVaDQSISLI 334 green sea turtle
XP_007254084 460 CAVaDQSVTIV 470 Mexican tetra
CDR01107     218 FAVaDRSVTIL 228 rainbow trout
XP_007429050 321 LAVaDQSISLV 331 Burmese python
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