Conserved Protein Domain Family
SPRY_PRY_TRIM65
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cd12896: SPRY_PRY_TRIM65 
PRY/SPRY domain in tripartite motif-containing domain 65 (TRIM65)
This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of TRIM65 proteins (composed of RING/B-box/coiled-coil core and also known as RBCC proteins). The SPRY/PRY combination is a possible component of immune defense. This protein family has not been characterized.
Links
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Statistics
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PSSM-Id: 293953
Aligned: 8 rows
Threshold Bit Score: 316.701
Created: 22-Jun-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6PJ69       322 LRRKLWQNYRNLTFDPVSANRHFYLSRQDQQVKHCRQs---rGPGGPGSFE-LWQVQCAQSFQAGHHYWEVRASDHsVTL 397 human
XP_002940023 344 LRAELYKDYRNLTFEPRSANKYIQLSRQNCKASHKMSsqgaeVLISSSTFQ-TWQVMCTEGFSSGHHYWEVELSAHfVEV 422 western clawed ...
CBN81166     332 GKEGLSAYRCSLTFDPRTANMHLFLSQENRRAEHLASgp-rpVPSHEARFDhTWQVLCFQGFKHGQHYWELEVSKPwAYL 410 European seabass
XP_415625    338 LRAELLKDHRNLTFDPDTANKYLELSWGQRRAKHGPTaa-vgWQERGRCFE-PWQVLCAQSYGQGCHYWEVTISSHsVVL 415 chicken
XP_006869734 327 LRRDLWQNYRNLTFDPDSANRHLHLSCQNRKVRHRREp---rDQASPNSFD-LWQVQCTESFQAGRHYWEVRVSSHsVTL 402 Cape golden mole
XP_008935159 205 LRAELLKDHRNLTFNPETANKYLELSKGRRRAKHGAGaa-cgRQERGPCFE-PWQVMCAEGYSHGHHYWEVEISSHsVIL 282 Merops nubicus
Q8BFW4       325 LRKKLWQNYRNLTFDPETANQYLHLSHKDQRVTHHFQa---qGPAKSGSFE-LWQVQCTQSFQTGQHYWEVRVSDHsVTL 400 house mouse
ELW68303     285 GTGRLQADYRNLTFDPSSANHHFSLSCQNRQVKHCRQp---qGLAKPGSFE-LWQVQCTQSFQSGRHYWEVCVSDHsVTL 360 Chinese tree shrew

Q6PJ69       398 GVSYPQLPRCRlgphTDNIGRGPCSWGLCVQEDSLQAWHNGEaQRLPGVs-gRLLGMDLDLASGCLTFYSLEp-qTQPLY 475 human
XP_002940023 423 GVAYDCLERSKn--eQNKIGRNPFSWSLQIHSRCHSAWHANTeQQLQAPk-yTKVGVSLDCEAGTLTFYGVRdggLELLH 499 western clawed ...
CBN81166     411 GVTYETIPRKEkg-kKCMVGMNDLSWSLQLDEHQLSAWHNGRrETLAGHsqhSRIGMLLDYEAGTLTYYGDG---QTRLH 486 European seabass
XP_415625    416 GVTYGGLPRHKvrgcKFNIGLDGGSWGLQVREDSYLAWHKGQeEKIQLRl-yTKLGVCLDCDHGLLSFYGLGd-gVQHIH 493 chicken
XP_006869734 403 GVAYPELERNKqgthIDNIGRGPSSWGLCLQEGGSQAWHNGEaKKLPAVs-gRLLGMDLDLASGHLAFYSLEp-qIQHLY 480 Cape golden mole
XP_008935159 283 GVTYHGLPWERqqghKFNIGLDRGSWGLQVREDCYLAWHKGRaEKIQDQl-yRNLGVSLDYGKGLLSFYGLGe-rMRLIH 360 Merops nubicus
Q8BFW4       401 GVTYPKLSRQKlgthTDNIGRGPCSWGLCIQEDSMQAWHNGKsQRLRGLp-gQLLGVDLNLTSGCLTFYSLEp-rTQPLH 478 house mouse
ELW68303     361 GVAYPGLTRHKpgphTDNIGREPCSWGLCIQEDSAQAWHCGKaQRLPRVs-aQLLGIDLDLTLGCLTFYSLEp-eTQRLH 438 Chinese tree shrew

Q6PJ69       476 TFHALFNQPLTPVFWLlEGRTLTLCH 501 human
XP_002940023 500 SFSCIFSQALYPTFWIgEGASVSLFQ 525 western clawed frog
CBN81166     487 AFHCAFTQELFPACWIgEGVSITLCS 512 European seabass
XP_415625    494 SFHSVFTEPLFPVFWLcEGRTVTLCH 519 chicken
XP_006869734 481 TFHAIFTQPLYPVFWLlEGRTLALCH 506 Cape golden mole
XP_008935159 361 SFHSIFTEPLYPVFWLcEGREVTLCR 386 Merops nubicus
Q8BFW4       479 TFYAVFSQPLFPVFWLlEGRTLTLCH 504 house mouse
ELW68303     439 TFHALFTQPLYPVFWLlEGRTLTLCH 464 Chinese tree shrew
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