Conserved Protein Domain Family
SPRY_HERC1
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cd12881: SPRY_HERC1 
SPRY domain in HERC1
This SPRY domain is found in the HERC1, a large protein related to chromosome condensation regulator RCC1. It is widely expressed in many tissues, playing an important role in intracellular membrane trafficking in the cytoplasm as well as Golgi apparatus. HERC1 also interacts with tuberous sclerosis 2 (TSC2, tuberin), which suppresses cell growth, and results in the destabilization of TSC2. However, the biological function of HERC1 has yet to be defined.
Links
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Statistics
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PSSM-Id: 293939
Aligned: 14 rows
Threshold Bit Score: 209.127
Created: 7-May-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q15751       2032 EVSFDpek---aqCCLVENgq-iLTHGSGGKGYGLASt---gVTSGCYQWKFYIvKENRGNEGTCVGVSRWPVHDFn-HR 2103 human
EEZ98478     1673 DMGFDink---chNCVIESnl-tLVHGFGGRGYGLGLq---aIRSGCYQWKILIvKENRGNEGTCIGVSKFPVRDFs-HR 1744 red flour beetle
EDV21026     1717 KANFDpdl---tiCCTVENlt-tLVHSVNGRGYGIAAs---sIKSGTRRWNFYVtQDTRNSDGVCIGMTRYPITDYn-YR 1788 Trichoplax ad...
XP_413753    2031 EVSFDpek---aqCCIVENgq-iLTHGSGGKGYGLASt---gVTSGCYQWKFYIvKENRGNEGTCVGVSRWPVHDFn-HR 2102 chicken
XP_002934599 2027 EVSFDpek---vqCCVVENgq-iLTHGSGGKGYGLASt---gVTSGCYQWKFYIvKENRGNEGTCVGVSRWPVHDFn-HR 2098 western clawe...
XP_001942852 1661 ELPFSfhee-ksfNCIIENsh-tVIHAHGGRAYALGSt---pFESGVYQWKFFIlKEHKGNEGSCIGISRYPIKDQn-YR 1734 pea aphid
CBJ26296      394 DAAFDpal--sskWVVVSEag-qLVSSAADNGHTHSLlh-qcLRRGTWSWELALeRESSGDETTCVGVAVNPVTNSc-YE 468  Ectocarpus si...
CBK21510      145 LIRFDasi--staGVAINSkgdfVINSNPNRSKFNAAfcspaLESGVIEIKWRLeDDRMNDEMTCFGFTTSPFESNknYE 222  Blastocystis ...
CBJ26296     1267 RASFEvdkdsmtsFSISEDg---QLYSALTSNNTCALld-vgVSHGKAAWEFVLeDDSPSDECSVFGIATKPPYSRc-YN 1341 Ectocarpus si...
EEY69908      472 AAVFEssv--cstGVVVEDg--gLVVRTRETSYQYAAvn-cgISSGKASWKFRLdTDTQDDEMTCFGAAILPVTVNg-YD 545  Phytophthora ...

Q15751       2104 TTSDMWLYRAYSGNLYHNGEqtltl---ssftQGDFITCVLDMEaRTISFGKNGEEPKLAFEDVDa-aELYPCVMFYSSn 2179 human
EEZ98478     1745 STTDMWLYRAYSGSLYHSGErdisf---qcytQGDYITVVLDMDaKTLSFGKNGEEPRVAFENIEa-tELYPCVMFYSTg 1820 red flour beetle
EDV21026     1789 TTSDMWLYRACNGSLYHGGElpsst--fpsyaGGDYITVIVDMQsCNIAFGKNDEEPMIAFENIDr-qELLPVIVFGNNs 1865 Trichoplax ad...
XP_413753    2103 TTSDMWLYRAYSGNLYHNGEqtltl---ssftQGDFITCVLDMEaRTISFGKNGEEPKLAFEDVDa-aELYPCVMFYSSn 2178 chicken
XP_002934599 2099 TTSDMWLYRAYSGNLYHNGEqtltl---psftQGDFITCVLDMEaRTVSFGKNGEEPKLAFEDVDa-gELYPCVMFYSSn 2174 western clawe...
XP_001942852 1735 TTSDMWLYRAYNGILYHGGQislvl---ktftQGDYITAIFDTEsRTLSFAKNNDYPVVAFQNIDtktKLYPCVLCYSTa 1811 pea aphid
CBJ26296      469 DSHQMWMVRCYSGETYSNGGrrnrv--trkihPLDSVRLTLNCEcGTLNLEVNGVDQGVVFSNVPp--EVHPAVCFYGVa 544  Ectocarpus si...
CBK21510      223 ESQSMWVYRCFNGDLYSQGRklers--lekahAGSEITFLFNLDeATVSISINERAYGVVFASIPt--PVYPLVLFYNSq 298  Blastocystis ...
CBJ26296     1342 SSQSLWMRRAYNGVLYNRGRqlpagqsmskihPGDVVRCEVDMDeGTLRFSVNGEKQDGGFDDVEg--EVFPCAGSYRSg 1419 Ectocarpus si...
EEY69908      546 SSPSLWMLRGYNGNLYARGHklnrt--igkvhPGDIVQVDIDLSeGTLAYKINGTDYGVVFTDLAg-hEVHPAVSFYGSg 622  Phytophthora ...

Q15751       2180 -PGEKVKICDM 2189 human
EEZ98478     1821 -PGEKVKITDM 1830 red flour beetle
EDV21026     1866 -PGERISLLDM 1875 Trichoplax adhaerens
XP_413753    2179 -PGEKVKICDM 2188 chicken
XP_002934599 2175 -PGEKVKICDM 2184 western clawed frog
XP_001942852 1812 -AGQKIKISDY 1821 pea aphid
CBJ26296      545 kSVRLVELKRI 555  Ectocarpus siliculosus
CBK21510      299 pPQRAVRLVSV 309  Blastocystis hominis
CBJ26296     1420 vTIRLLKMEMM 1430 Ectocarpus siliculosus
EEY69908      623 kVITLLGVTKW 633  Phytophthora infestans T30-4
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