Conserved Protein Domain Family
SPRY1_RyR
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cd12877: SPRY1_RyR 
SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this first SPRY domain of the RyRs.
Links
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Statistics
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PSSM-Id: 240457
Aligned: 13 rows
Threshold Bit Score: 214.869
Created: 15-May-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q15413     641 SIRPNIFLGvaeg-------saqYKKWYFELIIDQVDpfltaeptHLRVGWASSSGYapypgggEGWGGNGVGDDLYSYG 713  human
Q91313     643 SMRPNIYFGtceg-------stqFKKWYFEVIVDQVEpfvtaeatHLRVGWALTEGYspypgagEGWGANGAGDDLYSFA 715  bullfrog
EGD74144  1034 CFRASACVKcipldddagggttgYPKWYFEVEVTGVHss----raGLRVGWATNDYRd------ESSVGVLPGDDIFSWT 1103 Salpingoeca sp. ...
BAB84714   653 CMRPNVSISvdkn-------stvYKKWYFEVAIDKQEagts-rpvHFRVGWATTQGFrtylrggEGWGNSGVVDDLYSFG 724  Hemicentrotus pu...
BAF73476   643 SVRPNIFLGtceg-------stqYKKWYFEVMVDYVEsfvtaqatHLRVGWAMTEGFspypgggEGWGGNGVGDDLYSYG 715  zebrafish
EEN53162   392 SIRPNLYVGladg-------gvhYTKWYYELVVEEVQqnts-ipaHLRVGWANSSGFspypgggEGWGSNGVGDDFHSYG 463  Florida lancelet
NP_996757  640 SIRPNIFLGvaeg-------saqYKKWYFELIIDQVDpfltaeptHLRVGWASTSGYapypgggEGWGGNGVGDDLYSFG 712  chicken
CCD59582   608 SVRPNIFVGykdg-------gamYPKWYFEVIIDSLEtvth-qpaKIRVGWANTEGYnahpcggPGWGAAGLGDDLFSYA 679  Schistosoma mansoni
BAK26392   685 SMRPNIYVGkveg-------samYRRWYFELTLDHVEqvth-lepHFRVGWANTSGYvpypgggPKWGGNGVGDDIFSYG 756  two-spotted spid...
Q24498     647 SIRPNIFVGrvdg-------ssmYQKWYFEVTMDHIEqtth-mmpHLRIGWANTSGYvpypgggKKWGGNGVGDDLYSFG 718  fruit fly
CBY33379   678 SIRPNLFVGyger-------saqYRKWYFEVQVLQMDecslsqatHLRVGWANTSGFaaypgagDGFGTCGVGDDLYSFG 750  Oikopleura dioica
P91905     652 SMMPNVMLGvveg-------salFRKWYFEAEVEHIEtmtk-qtpYLRIGWANSVGFkpfpgsgDKMGCNGVGDDFYSYG 723  Caenorhabditis e...
EFX89429   646 SIRPNIYVGkvan-------savFLKWYFELTVDHVEvtth-lmpHLRVGWAKLPGYvaypgggEKWGGNGVGDDLYSYG 717  common water flea

Q15413     714 FDGlHLWSGRIPRavasi----------nqhlLRSDDVVSCCLDLgVPSISFRINGQPVQGMFENFNt-DGLFFPVMSFS 782  human
Q91313     716 FDGlHLWSGRVCRavash----------nqhlLTADDVVSCCLDLtVPSISFRFNGHPVQGMFENFNl-DGLFFPVSSFS 784  bullfrog
EGD74144  1104 FNGtNLHHGGRTFrsth-----------tlaaLKPGDVFGCHVDLeEGLMHFTINGREIATHFSNIMlkDVGLFPIACVD 1172 Salpingoeca sp. ...
BAB84714   725 FDGlNLWTGGVSKaapws----------gnrlLSKGDIVGVCFDLsVPRILYHVNGSPIKASFEGINl-EGMFFPVLSFS 793  Hemicentrotus pu...
BAF73476   716 FDGlHLWSGHVSRqvasp----------nqhaLAADDVVSCCLDLsVPSISFRINGHPVQGMFENFNl-DGLFFPAISFS 784  zebrafish
EEN53162   464 FDGmHLWTAGRARrvqsy----------dphmLTKGDIVSCCLDLtVPCISFRMNGNPVQGMFEHFNssPGLFFPVISCS 533  Florida lancelet
NP_996757  713 FDGlHLWSGRVPRavasv----------nqhlLSSDDVVSCCLDLgVPSISFRINGQPVQGMFENFCt-EGFFFPVVSLS 781  chicken
CCD59582   680 FDGsCLWAGGKPKratigtdeatneeatsnvpLKRGDIIGCLLDLtGPVIQFNVNGRLVRGYFQDFNi-SGLFYPCMSMN 758  Schistosoma mansoni
BAK26392   757 FDGlAFWTSGVANqvrtva--------egtpfLVKGDVVGCILDLnIPLITFTVNGLPVRGCFKGFNtdTGMFYPVISFS 828  two-spotted spid...
Q24498     719 FDGaFLWTGGRKTlvvdal--------peepfIRKGDVIGVAIDLsVPIITFTFNGVKVRGSFRDFNl-DGMFFPVMSCS 789  fruit fly
CBY33379   751 FDGlSLWTGHRSKyikqg----------kvelFKKGDIISCCLDLsAPSMSFRKNGKPIHGMFERFNl-EGMFFPCVSMS 819  Oikopleura dioica
P91905     724 FDGkSMYFGGKSRrvg-------------hklLEKGDVIGCSIDLtIPEIKFSVNGTYMSGSFKKFNi-DGYFFPVMSLS 789  Caenorhabditis e...
EFX89429   718 FDGaQLWTGGRSTvvhag---------mtepyIRKGDVIGCALDLsVPIMNFYLNGVKVKGNFKNMNl-DGMFFPVVSCS 787  common water flea

Q15413     783 agVKVRFLMG 792  human
Q91313     785 pgIKIRFLLG 794  bullfrog
EGD74144  1173 egVSLVFRLG 1182 Salpingoeca sp. ATCC50818
BAB84714   794 arVCARFILG 803  Hemicentrotus pulcherrimus
BAF73476   785 agVKARFLLG 794  zebrafish
EEN53162   534 tkVVVRFLFG 543  Florida lancelet
NP_996757  782 agVKARFLLG 791  chicken
CCD59582   759 akASARFLLG 768  Schistosoma mansoni
BAK26392   829 akYSCRFLFG 838  two-spotted spider mite
Q24498     790 skLSCRFLFG 799  fruit fly
CBY33379   820 sgVVVKFLLG 829  Oikopleura dioica
P91905     790 akVSCRFILG 799  Caenorhabditis elegans
EFX89429   788 arVSCRFLFG 797  common water flea
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