3HI2


Conserved Protein Domain Family
MqsR
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cd12869: MqsR 
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Motility quorum-sensing regulator (MqsR)
This family includes domains similar to the motility quorum-sensing regulator MqsR, a toxin that is highly upregulated in persisters (dormant cells found in biofilms that are a source of antibiotic resistance). MqsR pairs with its antitoxin MqsA, forming a unique family of toxin:antitoxin (TA) systems. MqsR has been found to be structurally homologous to the bacterial ribonuclease (RelE) toxins; however, its sequence is not similar to any other known toxins and therefore its molecular function is as yet unknown.
Links
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Statistics
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PSSM-Id: 240607
Aligned: 40 rows
Threshold Bit Score: 106.929
Created: 1-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide binding
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:3HI2: E. coli Motility quorum-sensing regulator (MqsR) binds antitoxin MqsA; contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              ##### ##  #      ##                   #    #    #         
3HI2_B         5 EKRTPHtrLSQVKKLVNAgq-vRTTRSALLNADELGl-dFDGMCNVIIGLsesDFYKSMTTYs--DHTIWQDVYRPrlv- 79  Escherichia col...
ABQ25500       2 EKRRPHydLKSIQAQMDCieamNLTMTARHGIKAIGm-aLGDALVVIKRLsmgNFYKAMTVHa--DSRVWQDVYHAewk- 77  Geobacter urani...
ABC75917       7 EKRRPHyeLSLFKELFSNaktrQITQIAHKGAASEGymtVEDIENVIEQLgskHFYKSMTTYh--SHEIWQDVYHYqdg- 83  Syntrophus acid...
ZP_08210371    3 VKRTPHhdLKAIQAKFADvdtlEITSKAARDAQKIGy-sLEDIVDVVQALepgDFIKSETAHnppNHRLWHDTYNIpcd- 80  Novosphingobium...
YP_412893      2 DKSKPHyeLDKVKSLIRAgq-yRITRVASEGGDKLGfknTQEIAEFVLTLkrtDFYKSMTSNm--NHKEWQDVYHGdgp- 77  Nitrosospira mu...
YP_001230185   9 MTDTPYysLEKIKRLLRNsdtrIITRRDRQEAAALGyadDDEMVDRVSQVtldEFKKKMPSEd--MPGYWQDVYNSiep- 85  Geobacter urani...
EIE01468       2 KSRKPRfsLEQIKDLIRSgk-aVVTSQAQKDALEEFglsEDEVLAEVLKLssaNFVESNPSKn--FPDEFLDVYKQiive 78  Leptospira lice...
CBX30395       2 IRDKAYysKKQIRNLILTgn-vQITEQARMSAQDDFgwdFDDICNAILVLpikSCYKAETRFg--NPQIWVDYYRAynl- 77  uncultured Desu...
ZP_07016156    2 AKWKPHydLKKSKSLIDSdk-yIIVKSAKTTAFKLNf-nEQRIKDVLLNIkpsDFSKSEEDWq--IKGHWQDAYKTcyd- 76  Desulfonatronos...
ZP_11203923    2 EKRVCHypLKKIKELITEgk-fSITKNAQKTAIEQFgygETEIINEVLNLhnsDFFKSMTSHn--NHLLWHDVYKKegn- 77  Leptospira meye...

Feature 1                            #    #
3HI2_B        80 -tgQVYLKITVih----dvLIVSFKE 100 Escherichia coli K-12
ABQ25500      78 -grALYIKFQRhe----efFIVSFKE 98  Geobacter uraniireducens Rf4
ABC75917      84 -dkKLYIKIQLsvdr-dkaVLIQMKR 107 Syntrophus aciditrophicus SB
ZP_08210371   81 -glWLYLKFAGetl--idvVLTSFKE 103 Novosphingobium nitrogenifigens DSM 193370
YP_412893     78 tkkVVYLKFIVtn----dvLILSFKE 99  Nitrosospira multiformis ATCC 25196
YP_001230185  86 dgtKIYIKLQIree---sgVIISFKR 108 Geobacter uraniireducens Rf4
EIE01468      79 skeEAYIKLQIren---fgVIVSFHL 101 Leptospira licerasiae serovar Varillal str. VAR 010
CBX30395      78 kgeDVYTHFYVdsd---nlIIDSFKE 100 uncultured Desulfobacterium sp.
ZP_07016156   77 -ghRLYVKWKItenkeehlLVLSFKE 101 Desulfonatronospira thiodismutans ASO3-1
ZP_11203923   78 -nyKLYIKIQIsns---ntLVISFKG 99  Leptospira meyeri serovar Hardjo str. Went 5

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