1KVD,1KVE


Conserved Protein Domain Family
Killer_toxin_beta
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cd12839: Killer_toxin_beta 
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Beta subunit of killer toxin from halotolerant yeast
This family contains the beta subunit of killer toxins that are secreted by several strains of yeasts and fungi. These toxins are proteinous substances that kill sensitive strains. The halotolerant yeast Pichia farinosa KK1 strain produces the SMK toxin, with maximum killer activity under acidic pH and high salt concentration. This toxin is composed of alpha and beta subunits that interact tightly with each other under acidic conditions but easily dissociated and loose activity under neutral conditions. It shares topology to that of the fungal killer toxin, KP4, which contains a rare structural motif, suggesting that these toxins may be evolutionally and/or functionally related.
Links
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Statistics
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PSSM-Id: 214012
Aligned: 5 rows
Threshold Bit Score: 106.641
Created: 18-Oct-2012
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 43 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1KVD: Millerozyma farinosa (Pichia farinosa) killer toxin beta subunit interacts with alpha subunit; contacts at 4.0A
  • Citation:PMID 9016714
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     ####### # ##        ### ##########    #########     ## # # #     # #   ####
1KVD_B      4 TTIWGVGADEAIDKGTPSkNDLQNMSADLAKNGFKghqGVACSTVKDgn-kDVYMIKFSLAGGSNDPGGSPCSDD 77  Millerozyma farinosa
EGV66503   46 TTVWGIGADDRIDKSGATkKTLSEWAYKIKKAQGGkqgHQCVSIFSSdnkqRDFDIEFAFYDNSYSPQGSSCEAK 120 Candida tenuis ATCC 10573
P19972    149 TTIWGVGADEAIDKGTPSkNDLQNMSADLAKNGFKghqGVACSTVKDgn-kDVYMIKFSLAGGSNDPGGSPCSDD 222 Pichia farinosa
CCE85598  149 TTLWGVGADEAIDKGTPStDDLQNMSADLAKNGFKgdqGVACSTLKDgn-nDVYMIKFSLAGGSNDPGGSPCSDD 222 Millerozyma farinosa CB...
1KVE_B      4 TTIWGVGADEAIDKGTPSkNDLQNMSADLAKNGFKghqGVACSTVKDgn-kDVYMIKFSLAGGSNDPGGSPCSDD 77  Millerozyma farinosa

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