Conserved Protein Domain Family
Esterase_713_like-2

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cd12809: Esterase_713_like-2 
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds
This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.
Statistics
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PSSM-Id: 214008
Aligned: 37 rows
Threshold Bit Score: 324.179
Created: 21-Aug-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic site
Feature 1:catalytic site [active site]
Evidence:

cd12809 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd12809 is a member of the superfamily cl21494
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
EIW82460       10 PHTRRYLYVGGEYSrq---------gSSAISHGQMYVEHLVPve---vtKQHPLLFIHGd----gMSGTNFLNTPEGKPG 73   Coniophora pu...
XP_003053893   37 IAEREAPSEDAPAPvqpv-----vsyDRLVVTNPLAREPIRPeae--cvRTTFHIHVDWqlgcnlATASNMTTKPDGQPG 109  Nectria haema...
EFY84774      373 QPNSWQPAPHSSWDtytpkftpvspsLPQPKEAKMYVEKYTPhe---ptWAYPIVLVHGd----fHTGNIWTIKPDGGQG 445  Metarhizium a...
EGU71852       43 PYTRDFFYIGGRSAkg---------tSGTITVDQVYVEKLTPtkq--wtQKHPLVFFHGg----gLSGSTWLNTPDNREG 107  Fusarium oxys...
EGX89389       18 FTKRTTFYVNIEWEagc------qpnQGTNVRGQMYVESLEPqr---ktQHYPVVLIHGd----yHTSQVWLTKPDGDPG 84   Cordyceps mil...
EHA57239       51 AFHRDAFYVGGRDLkt---------dRGTSTADQLYVEKLTPtgg--vtQANPLVLFHGg----gFSGITWLNTPDNRKG 115  Magnaporthe g...
EHK39815        2 PARCTTFFVNRQYAte--------hsIGGTYSGQMYVELYEPvhavplhMQRNIVLLHGd----fFTAQTWLEKPDGSQS 69   Trichoderma a...
CCC06592        3 QPHHDVPPTAASFD------------RAVFSIGQMRVEKLEPtvn--hrSLMPIILLHGd----yHTGSMWLTKPDSRPG 64   Sordaria macr...
CCF46133       45 LHSREFFYVGGQTAsd---------pTGNITVGQLYVEKLTPli---klRPTPLVFIHGg----gVSGTTWLNTPDNRPG 108  Colletotrichu...
CCF38581       43 PYTRDFFYVGGRALet---------aSGELTADKLYVEKISPvv---plRSKPVVFFHGg----gCSGTTWLNTPDNRKG 106  Colletotrichu...
Feature 1                                                                                         
EIW82460       74 WADFFMRQGYEVYIVDQPARARSPWqstldgntst---------fdtymieshFTATq------yYKLWPHAe------L 132  Coniophora pu...
XP_003053893  110 WASYFLRQGFTVYIVDMPPSGRSNSvtvshcdssyy------hsmsiqtveseLTAPekvtatnpRIKYPAAk------F 177  Nectria haema...
EFY84774      446 WASFFINKGFTVYVVDLPACGRSMEfdrtvvkwsnyas--cmakptrdnveatLTAAs------tFQRWPDAh------K 511  Metarhizium a...
EGU71852      108 WASYFTKKGYVVYLVDNNAIGRSAEnaiasfpmaa--------gsatetvmkfFTSPe------nYETYPQAk------L 167  Fusarium oxys...
EGX89389       85 WASYFLGKGFHVYLVDLPGTGKSNNlteeainnaqvrsikasqiereatatkvFNHIt-------DPRWLTAl------K 151  Cordyceps mil...
EHA57239      116 WASHFIEQGYAVYIVDSIAVGRSTQieaagyapvga-------gspvetlrdiFTAPq------dVNQYPQSq------L 176  Magnaporthe g...
EHK39815       70 WAAYFLTKGYNVYVVDLPGVGRSSFfnkndyqvpgvpr--tvrwltddfveqeFTASe------qFPLPDGSlawasarR 141  Trichoderma a...
CCC06592       65 WAVFFAERGHRVYAPQLPFQGQSDTsayyervkv----------itprtienlYTATnk----tnDPEWLVAk------K 124  Sordaria macr...
CCF46133      109 WATYFLKQGYQVYLIDANSIGRSTVnnpaafsmav--------gmsdefvemgFTAVk------aYNTYPQSq------L 168  Colletotrichu...
CCF38581      107 FASYFVEQGYVVYIVDAAGNGRSTNmdlegfplsa--------gssstlvemgFSAPg------aYNAYPQSr------L 166  Colletotrichu...
Feature 1                                                                  #                      
EIW82460      133 HTQWPGn-GSRGDPIFdafyRSTLPrltsavetsrlMKTAGSKLLdtiGKPVILFTHSQSGQFGWILADsrPNHIHSIVA 211  Coniophora pu...
XP_003053893  178 HDKWPGsgLHHDDPYFanyyASLTPiclkkvqrqtlAQDSLQELLk-hTGKAFLIGEGTGSMMAWLATDvePDLVAGVIA 256  Nectria haema...
EFY84774      512 HTQWPGt-GLRGDEFFetymASTVPlyfrrherqafGKEALTTLVh-qIGQVILLGEGSGATLSWLAADalPDSVKAVLA 589  Metarhizium a...
EGU71852      168 HTQWPGt-GADGDPVYdqfkKSLIPlttnfvgqenaLRAGGCELLsllGEKAFLISHSLGSRNPLLLSNdcPEYIAGSIN 246  Fusarium oxys...
EGX89389      152 HDKWPGt-GMRGDPAFdrycASLSPlfftledrqtlAQNALRSLLk-iTGKAVLIGEGTGATASWLASDviPENVVGVVA 229  Cordyceps mil...
EHA57239      177 HTQWPGt-GREGDPVFeqfrRSALPlsvnmtrhetgMRAAGCELLsllGTPSFLISHSFGAVTPFLLTNdcPQLVAGNIN 255  Magnaporthe g...
EHK39815      142 HNQWPGt-GRRGNSMFnlfmDSTTDmvlpklqheelGAIAVTDLLk-qIGPSFLIGHGTGATIGMLTADanPRLVRGLVS 219  Trichoderma a...
CCC06592      125 HTQWPGs-GVRGNPIFdqyfNQLVPmymdvherqaaAQEAVESLLrllKRPAILIGHGSGANVAWLAADvaPDLVHAIVA 203  Sordaria macr...
CCF46133      169 HTQWPGt-GMRGDPFFeqfqQSFIPytssyvpqelaVRAAACELLsliDAQSYLVSHSLGSKFAIGISNdcPEHLAGSIN 247  Colletotrichu...
CCF38581      167 HTQFPGt-GRAGDAAFenfkNSMVPyttnnityenaMRAGGCRLLe-lVGKSYVVGHSAGGSAGILLSNdcPDLLAANIN 244  Colletotrichu...
Feature 1          #                                                                              
EIW82460      212 LEPIGPPFqnavfgtdparpfglteipvqfsppiqsp------------------------------------------- 248  Coniophora pu...
XP_003053893  257 IEPTGPPFgttirtpvnghriftqivrhvpgvrvygltditltydppanfhgtilpsdh-------------------em 317  Nectria haema...
EFY84774      590 VEPAGPPGgtnrvlkdnmlvftnqvryfaqhrpygvadipltfdppvpepvydqhgvt--------------------qp 649  Metarhizium a...
EGU71852      247 LEAATSPFwsyaeglggfagspwgltntpvtydppvsd------------------------------------------ 284  Fusarium oxys...
EGX89389      230 VEPPGPPFcdktverngkrkfdsftsfnpdrlkyglsnipltfdpparpeidprggptgllpsaldqpgmnpereptglh 309  Cordyceps mil...
EHA57239      256 LEPSAGPFyqfnldgsgqeaflwgmsntpidydppvte------------------------------------------ 293  Magnaporthe g...
EHK39815      220 IEPDGPPCawpgrpvdgrmtyspflqydpnirkygvsdapltfspalqpapga--------------------------- 272  Trichoderma a...
CCC06592      204 VEPLGSPFgsalqntngelrptgkfaraagvrpygltdipmqfdppvaapesfeelf----------------------g 261  Sordaria macr...
CCF46133      248 IEPSTIPF------------------------------------------------------------------------ 255  Colletotrichu...
CCF38581      245 LESSTIPFfwytygtagffnngwglantplnytppise------------------------------------------ 282  Colletotrichu...
Feature 1                                                                                         
EIW82460      249 --------------------qdlgplvaidhgpnytcllqhsparqltNVSKVPVFMVTSESg--YHSVYDGCTVQFLRD 306  Coniophora pu...
XP_003053893  318 pldlvermrpdtkgtcylqrnlhedeiifnhetgqhemsgltrfrelmNLKKVPQAVVTAHAs--SHTTYDWTTVAFMVQ 395  Nectria haema...
EFY84774      650 plnlfpsvagpdnavyllqrcgmdlvqadtmgtvlpwdaymeiprklvALGKVRQVVVTADAs--HHTTCDAATVKFMRQ 727  Metarhizium a...
EGU71852      285 ------------------pselesesvgeetlahrncylqveparklpQINKVPYLLLTGEAs--VHITYDHCVIDFLKQ 344  Fusarium oxys...
EGX89389      310 pldlaefshtttgkhivlqyspenipagftflkkltngdgtmhvrkliNLSKMRHVMITGEAs--PHSEYDSSTIHFMQQ 387  Cordyceps mil...
EHA57239      294 ------------------asglktefvgnatavqgrcrllaepapklpKVASVPYLAVAGEAs--IHILWDHCAAMFIRQ 353  Magnaporthe g...
EHK39815      273 ----hplkiqvrqgknnngcymlqqkqdniliynmrvadgqekvpqlvRLATVPHAVYTSESs--PHSIYDWATTNFLRQ 346  Trichoderma a...
CCC06592      262 giypdfepipvtkfyargrqgkfcfeqdlagmrvgsptesraeprkltNLVGIPQLVVTTEAs--FHRLSDWATVHFLRQ 339  Sordaria macr...
CCF46133      256 ------------------------------------------------RAYGYALGSTAANPwglTNTPVDYEPAVSSAA 287  Colletotrichu...
CCF38581      283 ------------------aselkivevgnstvarrscyrqaeparklpNIASVPYLMVTGEAs--VHITFDHCIVDYLEQ 342  Colletotrichu...
Feature 1                            #                     
EIW82460      307 AGvDVLHLRLEdlGIKGNGHMMFMEKNSEEIADVVLGWISS 347  Coniophora puteana RWD-64-598 SS2
XP_003053893  396 AGvPVQWIKLDenQIFGNGHLMFLETNSDDIAGLLTKWIDS 436  Nectria haematococca mpVI 77-13-4
EFY84774      728 AGvDVDHVQLGeaGVYGNGHLMFLEKNSDNVAQFVLNWIAA 768  Metarhizium acridum CQMa 102
EGU71852      345 AGgKPEWINLAdwGIKGNGHFLHVEKNNMQIAGIVDAWIQK 385  Fusarium oxysporum Fo5176
EGX89389      388 AGlIVDCGFLEkyQIRGNGHLMFLETNSDEVASHIMRWIQT 428  Cordyceps militaris CM01
EHA57239      354 VGgTADYVKLAdvGVRGNGHFSHMEKNNLEVAQVVQDWIRK 394  Magnaporthe grisea 70-15
EHK39815      347 AGnMVDWWNLPdhKIYGNGHLMHLEKNSDTIVQNIDVWMAK 387  Trichoderma atroviride IMI 206040
CCC06592      340 AGtTVKHHRLEehGIRGNGHLCFLEKNSNDVANHVLKWLHN 380  Sordaria macrospora k-hell
CCF46133      288 EL-NASVESVG--QESXARRXXDPPEGARPLGRTPEGAPSA 325  Colletotrichum higginsianum
CCF38581      343 VGaKPEWIKLAdrGIKGNGHFMHIEKNNGDIAKLVLNWIRQ 383  Colletotrichum higginsianum

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