3HM6


Conserved Protein Domain Family
RasGAP_plexin_B1
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cd12793: RasGAP_plexin_B1 
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Ras-GTPase Activating Domain of plexin-B1
Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
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Statistics
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PSSM-Id: 213353
Aligned: 6 rows
Threshold Bit Score: 632.452
Created: 1-Aug-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative Rap
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Rap interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                 #       
3HM6_X         71 GIPFLDYKVYAERIFFPGHRESPLHRDLGVpESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLETQRTFSaRDRAYVASLL 150  human
CAF93155      778 GIPFLDYRMYAERIFFPGHRESPLRRDLDVqECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSpRDRAYVASLL 857  spotted green...
NP_001244194 1342 GIPFLDYKSYAERIFFPGHRESPLQRDLDIpECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSpRDRAYVASLL 1421 chicken
XP_003198833 1633 RIPFLEYRMYAERIFFPGHRESPLRRDLDVqECRRATVEQGLIQLSNLLNSKLFLTKFIHTLESQRTFSpRDRGYVASLL 1712 zebrafish
XP_002938438 1537 GIPFLDYKSYAERIFFPGHRESPLQRDLDVpEGRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSaRDRAYVASLL 1616 western clawe...
CAF94441       54 GVPFLDYRAYIERIFFPSHQESPLRRDLDVpESRRQTVTQGLIQLSNLLNSKLFLTKFIHTLEVQRTFSpRDRAYVASLL 133  spotted green...

Feature 1                                        #   #####      #                                 
3HM6_X        151 TVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKG 230  human
CAF93155      858 TVALHSKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRESAGESLYMLFRAIKHQVDKG 937  spotted green...
NP_001244194 1422 TVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDKG 1501 chicken
XP_003198833 1713 TVALHSKLEYFTDILKTLLNDLVEQYIAKNPKLMLRRTETVVEKLLTNWISICLYGFLRNSAGESLYMLFRAIKHQVDKG 1792 zebrafish
XP_002938438 1617 TVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSAGEPLYMLFRGIKHQVDKG 1696 western clawe...
CAF94441      134 TIVLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTESVVEKLLTNWMSICLFTFLRESAGESFYMLFRAIKHQVDKG 213  spotted green...

Feature 1                                                                                         
3HM6_X        231 PVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpdpr 310  human
CAF93155      938 PVDAVTGKakytlndnrllredveyrtlviepffkfdptgccctgifqfklfplilqtlnvlvqgaglsenqplptkvld 1017 spotted green...
NP_001244194 1502 PVDWVTGKakytlndnrllredleyrtltlnaltqagvaaggaedsqgisakvldcdtitqvkekildqiykgmpychrp 1581 chicken
XP_003198833 1793 PVDAVTGKakytlndnrllredleyrtltvnvlmqgigmneaqpvaakvldcdtitqvkekildqvykgtsfshrphtds 1872 zebrafish
XP_002938438 1697 PVDCVTGKakytlndnrllrddveyktltlnaimqtntgitceeeaqglpvklldcdtitqvkekildqiykgtpycnrp 1776 western clawe...
CAF94441      214 PVDVVTGKakytlndnrllredveyrtltlnvlipaaatcsgattqivpakvldcdtitqvkekiveqtwkgtsfsqrph 293  spotted green...

Feature 1                                                                                         
3HM6_X        311 tldvewrsgvaghlilsd-------------------------------------edvtsevqglwrrlntlqhykvpdg 353  human
CAF93155     1018 cdtitqvkeklldqvykgtsfshrphsdsldlentekrscfdpewrsgvaghlilsdedltsvvqgswkrlntlqhykvp 1097 spotted green...
NP_001244194 1582 dpdtldlewrsglaghli------------------------------------lsdedvtsvvqgtwkrlntlqhykvp 1625 chicken
XP_003198833 1873 vdlewrsgvaghlils----------------------------------------dedltsvvqgnwkrlntlqhykvp 1912 zebrafish
XP_002938438 1777 npealdlewrsglaghli------------------------------------lsdedltsvvhgswkrvntlqhykvp 1820 western clawe...
CAF94441      294 igslqlewragvaghlils-----------------------------------dedltsvvqdswkhlntlqhykvpdg 338  spotted green...

Feature 1                                                                                         
3HM6_X        354 atvalvpcltkhvlrenqdyvpgertpmledvdeggirpwhlvkpsdepepprprrgslrggerERAKAIPEIYLTRLLS 433  human
CAF93155     1098 egatvalvarhskhihhdnhdymagektpmledadeggvrlwhlvkaseepelpkhrrgslrerERAKAIPEIYLTRLLS 1177 spotted green...
NP_001244194 1626 dgatvalvprltkhihrenqdyipgektpmledadeggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLS 1705 chicken
XP_003198833 1913 dgatvalvprhskhihhdthdyiagektpmledadeggvrlwhlvkaseepelpkhrrgslkerERAKTIPEIYLTRLLS 1992 zebrafish
XP_002938438 1821 dgatvalvprlskhihpenhdyipgektpmledsdeggvrvwhlvkptdepelpkhrrgslrdrERAKAIPEIYLTRLLS 1900 western clawe...
CAF94441      339 atvalvprstkhhlhdshdyipvektpvlddgeeggvrlwhlvkaneeselpnhrkgsvrerggERAKAIPEIYLTRLLS 418  spotted green...

Feature 1                                                           #       ##  ##                
3HM6_X        434 MKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGIsDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDN 513  human
CAF93155     1178 MKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDEQAGQHGIsDSETIHIWKTNSLPLRFWINIIKNPQFIFDVQASDH 1257 spotted green...
NP_001244194 1706 MKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQALHYGIaDPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDN 1785 chicken
XP_003198833 1993 MKGTLQKFVDDLFTVILSTSRPVPLAIKYFFDLLDDQAVRHGIsDSETIHIWKTNSLPLRFWINIVKNPQFIFDVQVSDN 2072 zebrafish
XP_002938438 1901 MKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAISHGInDPETIHIWKTNSLPLRFWINIIKNPQFVCDVQTSDN 1980 western clawe...
CAF94441      419 MKGTLQKFVDDLFTAILSTSRPVPLAVKYFFDLLDEQALQHSItDPETIHIWKTNSLPLRFWINILKNPQFIFDVQTSDH 498  spotted green...

Feature 1                  #      # #      ##                                                     
3HM6_X        514 MDAVLLVIAQTFMDACTLADHKlGRDSPINKLLYARDIPRYKRMVERYYADIRQTVpASDQEMNSVLAELSWNYSGDLGA 593  human
CAF93155     1258 VDAVLSVIAQTFMDSCTIAEHKlGRDSPINKLLYARDIPRYKQMVERYYADIRQTVsASDQEMNSALAELSRNYSGELNY 1337 spotted green...
NP_001244194 1786 VDAVLLVIAQTFMDSCTIADHKlGRDSPINKLLYARDIPRYKQMVERYYADIRQTIsASDQEMNSALAELSRNYSGDLNS 1865 chicken
XP_003198833 2073 VDAVLSVIAQTFMDSCTTTEHKlGRDSPINKLLYARDIPRYKQMVERYYADIKQTIsASDQEMNSALAELSRNYSGELNY 2152 zebrafish
XP_002938438 1981 VDAVLSVIAQTFMDSCTIADHKlGRDSPINKLLYARDIPRYKQMVERYYSDIRQTIsASDQEMNSALAELSRNCSGELNS 2060 western clawe...
CAF94441      499 VDAVLSVIAQTFMDSCTIADHKlGRDSPINKLLYARDIPRYKKMVERYYADIQHTVsASDQEMNSSLAEISRNYTAEVNC 578  spotted green...

Feature 1                                                           
3HM6_X        594 RVALHELYKYINKYyDQIITALEEDGTAQKMQLGYRLQQIAAAVENKVTD 643  human
CAF93155     1338 LVALHELYKYINKYyDQIITALEEDSTAQKMQLGYRLQQIAAAVENKVTD 1387 spotted green pufferfish
NP_001244194 1866 LVALHELYKYINKYyDQIITALEEDPTAQKMQLGYRLQQIAAAVENKVTD 1915 chicken
XP_003198833 2153 LVALHELYKYINKYyDQIITALEEDTTAQKMQLGYRLQQIAAAVENKVTD 2202 zebrafish
XP_002938438 2061 LVALHELYKYINKYyDQIIEALEEDPTAQKMQLGYRLQQIAAAVENKVTD 2110 western clawed frog
CAF94441      579 VVALHDLYKNNNKKhAHIITALEEDSTAQKMQLSYRLQQIAAAVENKVTD 628  spotted green pufferfish

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