Conserved Protein Domain Family
RasGAP_plexin_B2
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cd12792: RasGAP_plexin_B2 
Ras-GTPase Activating Domain of plexin-B2
Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Links
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Statistics
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PSSM-Id: 213352
Aligned: 8 rows
Threshold Bit Score: 759.931
Created: 1-Aug-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Rap
Feature 1:putative Rap interface [polypeptide binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     #   
O15031       1271 GIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPepRRPVVEQALYQFSNLLNsKSFLINFIHTLENQREFsaRAKVYF 1350 human
AAI08846       17 GIPFLDYKTYTDRVFFLSSKDGEKDVMITGKLDIPeaRRQTVEVALNQFSNLLNsKSFLTIFIHTLESQKDFsaREKLYL 96   African clawe...
CAI21091      351 RIPFLDYKNYTDRVFFLPSKDGANDVMITGKLDIPenRRAIVDQALNQFSNLLNsKTFLINFIRTLEGRQEFnaRNKVYF 430  zebrafish
ACM48164     1281 RIPFLDYKTYTDRVFFLPSKDGANDVMITGKLDIPesRRATVTQALNQFSNLLNsKTFLINFIRTLEGRPDFnaRAKVYF 1360 zebrafish
CAG08638      163 RIPFLDYKTYTDRVFFLTSKDGANDVMITGRLEIPhaRRGTVMQALNQFSNLLNsKTFLINFIRTLERSNDFnaRAKVYF 242  spotted green...
XP_003770851 1543 GIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPesRRQTVEQALNQFSNLLNsKSFLINFIHTLENQREFsaRAKVYF 1622 Tasmanian devil
XP_423623    1273 GIPVLDYKTYTDRVFFLPSKDGEKDVMITGKLDIPeaRRQTVEQALNQFSNLLNsKSFLINFIHTLENQREFsaRAKVYF 1352 chicken
XP_003448161 1300 RIPFLDYKTYTDRNFFLPSKDGANDPMITGKLQIPeaRRATVAQALNQFSNLLNsKTFLINFIHTLERRPDFnaRSRGYF 1379 Nile tilapia

Feature 1                                             #   #####      #                            
O15031       1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQYVvaKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430 human
AAI08846       97 ASLLTVALHGKLEYYTDIMRALLMELLDQYVa-KNPKLLLRRSETVVERMLSNWMSICLYQYLKDTVGEPLYKLFKAIKH 175  African clawe...
CAI21091      431 ASLLTVALHGKLEYYTDIMRTLLLELMEEYVhsKNPKLMLRRSETVVERMLCNWMSICLYQFLKDSAGEPLYKLFKAIKH 510  zebrafish
ACM48164     1361 ASLLTVALHGKLEYYTDIMRTLLLGLMEDYVhsKNPKLLLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFRAIKH 1440 zebrafish
CAG08638      243 ASLLTVALHGKLEYYTDIMRTLLLELMEEYVhsKNPKLMLRRSETVVERMLCNWMSICLYQFLKDSAGEPLYKLFRAIKH 322  spotted green...
XP_003770851 1623 ASLLTVALHGKLEYYTDIMRTLFLELMEQYVvaKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 1702 Tasmanian devil
XP_423623    1353 ASLLTVALHGKLEYYTDIMRTLFLELMEQYVvaKNPKLMLRRSETVVERMLSNWMSICLYQYLKDNAGEPLYKLFKAIKH 1432 chicken
XP_003448161 1380 ASLLTVALHGKLEYYTDIMRTLLLELMDEHVqnKNPKLMLRRSETVVERMLCNWMSICLYQFLRDTAGEPLYKLFKALKH 1459 Nile tilapia

Feature 1                                                                                         
O15031       1431 QVEKGPVDAVQKKakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510 human
AAI08846      176 QVEKGPVDAVQAKakytlndtgllgddveytqltvnvivqeegaepvpvkvlncdtitqvkekivdqvyrnipyslrpka 255  African clawe...
CAI21091      511 QVEKGPVDAKMKKakytlndtgllgddveysiltlqvlvhgegpdvtpvkvlncdtisqvkekiieqvyrnlpysqrpvv 590  zebrafish
ACM48164     1441 QIEKGPVDVQVKKakytlndtgllgddveysiltlqvlvqgegpditpvnvlncdtisqvkekileqvyknlpysqrpkv 1520 zebrafish
CAG08638      323 QIEKGPVDARVKKakytlndtgllgddveysvltlqvlvqdegpdvtsvkvlncdtisqvkekiieqvyknlpysqrpkv 402  spotted green...
XP_003770851 1703 QVEKGPVDAVQRKakytlndtgllgddveyipltvnvivqeegvdaipvkvlncdtitqvkekiidqvyrtlpcsrwpka 1782 Tasmanian devil
XP_423623    1433 QVEKGPVDAVLKKakytlndtgllgddveytqltvnvyvqdggtdstpvkvlncdtisqvkekiidqvyrnlpcsqwpka 1512 chicken
XP_003448161 1460 QIEKGPVDAKMKKakytlndtgllgddveysvltlqvlvhgegpdvtpvkvlncdtisqvkekiidqvyrnlpysqrpkv 1539 Nile tilapia

Feature 1                                                                                         
O15031       1511 dsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvwh 1590 human
AAI08846      256 dslalewrpgstaqilsdldltsqkegrskqyntlmhynirdnatlilsrmgisqqqeqnhqdipgerhelledenkawh 335  African clawe...
CAI21091      591 dsvalewrpgstgqil-sdldltsqkegrwkrintlahynvrdgatlvlsrvlhtqqsfdqnmdnheernalleddkvfh 669  zebrafish
ACM48164     1521 dsvtlewrpgstgqil-sdldvtsqkegrwrrintlahynvrdnatvilssvqhtqqsydqnhdsheernalleddkvfh 1599 zebrafish
CAG08638      403 dsvtlewrpgstgqil-sdldltsqkegrwkrintlahynvrdnatlvlsrvpqtqqnydqnqenheernalleddkvfh 481  spotted green...
XP_003770851 1783 esvvlewrpgstaqilsdldltsqrdgrwkrintlmhynvrdgatlilskmgisqqpedsqqdlpgerhalleeenrvwh 1862 Tasmanian devil
XP_423623    1513 esvalewrpgstaqilsdldltsqrdgrwkrintlmhynvrdgatlilskmgisqqpednqqdvpgerhalledenkvwh 1592 chicken
XP_003448161 1540 esvalewrpgstgqil--sdldltsqkegrwkrlntlahynvrdnatlvlsrvlhtqsfhqhqdsheeknalleddntfh 1617 Nile tilapia

Feature 1                                                                                         
O15031       1591 lvrptdevdegkskrgsvkeKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNI 1670 human
AAI08846      336 lvrpadevdegkskrgsmkeKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLNSNQVVPPAVKYFFDFLDEQAEKYEI 415  African clawe...
CAI21091      670 lvrpadeleevkskrgsmkdKATTKAITEIYLTRLLSMKGTLQQFVDDFFRSVLCSGTVVPPAVKYFFDFLDEQAQKHDN 749  zebrafish
ACM48164     1600 lvrpadeldeikskrgsikdKSMTKAITEIYLTRLLSVKGTLQQFVDDFFHSVLCSGAAVPPAVKYFFDFLDEQALRHEN 1679 zebrafish
CAG08638      482 lvrpadeldeikskrgsikdKSMTKAITEIYLTRLLSVKGTLQQFVDDFFRSVLCTGAVVPPAVKYFFDFLDEQALKHSV 561  spotted green...
XP_003770851 1863 lvrptdeveegkskrgsmkeKERTKAITEIYLTRLLSVKGTLQQFVDNFFHSVLTPSPTVPPAVKYFFDFLDEQAEKHEI 1942 Tasmanian devil
XP_423623    1593 lvrpvdeideskskrgsvkeKERTKAITEIYLTRLLSVKGTLQQFVDDFFHSVLNSNHVVPPAVKYFFDFLDEQAEKHDI 1672 chicken
XP_003448161 1618 lvrqpdeidevkskrgsmkdKAMTKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCSSSVVPPAVKYFFDFLDEQAQRHDN 1697 Nile tilapia

Feature 1                #       ##  ##                         #      # #      ##                
O15031       1671 qDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVhEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKK 1750 human
AAI08846      416 kDEDTVHIWKTNSLSLRFWVNILKNPHFIFDVHVhQVVDASLSVIAQTFMDACSRTEHKLSRESPSNKLLYAKEISTYKK 495  African clawe...
CAI21091      750 vDDETIHIWKTNSLPLRFWVNILKNPHFIFDVHLtEVVDASLSVIAQTFMDACTKTEHKLTRESPSNKLLYAKEISTYKK 829  zebrafish
ACM48164     1680 vDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVtEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNKLLYAKEISTYKR 1759 zebrafish
CAG08638      562 -DDETIHIWKTNSLPLRFWVNILKNPNFIFDIHVsEVVDASLSVIAQTFMDACTKSEHKLSRDSPSNKLLYAKEISTYKK 640  spotted green...
XP_003770851 1943 kDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVpEVVDSSLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKK 2022 Tasmanian devil
XP_423623    1673 kDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVhEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISNYKK 1752 chicken
XP_003448161 1698 vDEETLHIWKTNSLPMRFWVNILRNPHFIFDVHVtEVVDASLHVIAQTFMDACTKTEHKLSRESPSNKLLYAKEISTYKK 1777 Nile tilapia

Feature 1                                                                                         
O15031       1751 MVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDsLNTLVALHQLYQYTQKYYDEIINALEEDPAaQKMQLAFRLQQIAAA 1830 human
AAI08846      496 MVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTEsLNTLVALHQLYQYTNKYYDEIINALEEDPAaQRMQLAYRLQQIAAA 575  African clawe...
CAI21091      830 MVDDYYKGIRQMVPVSDQDMNTHLAEISRSHTDkLNTQAALHQLYQYASKYYDGIISSLEEDPAaQSKQLTLRLQQIAAA 909  zebrafish
ACM48164     1760 NVDEYYKGIRQMVSVSDQEMNTHLAEVSREHTDkLNTQVALHQLYRYASKYYDGIIMSLDEDPTaQSKQLTLRLQQIAAA 1839 zebrafish
CAG08638      641 MVDDYYKGIRQMVPVSDQDMNTHLAEVSRSHTDkLKTQVALHQLYQYASKYYDGIIASLDEDPAaQSKQLTLRLQQIAAA 720  spotted green...
XP_003770851 2023 MVEDYYRGIRQMVQVSDQDMNTHLAEISRAHTDsLNTLVALHQLYQYTQKYYDEIINALEGDPAaQKMQLAFRLQQIAAA 2102 Tasmanian devil
XP_423623    1753 MVEDYYKGIRQMVPVSDQDMNTHLAEISRAHTDsLNTLVALHQLYQYTNKYYDEIINALEEDPAaQKMQLAFRLQQIAAA 1832 chicken
XP_003448161 1778 MVDDYYRGIRQMVPVSDQDMNTHLAEVSRQHTDkLNTQVALHQLYQFASKYYDVIIQSLDEDPAaQNKQLTLRLQQVAAA 1857 Nile tilapia

Feature 1                
O15031       1831 LENKVTD 1837 human
AAI08846      576 LENKVTD 582  African clawed frog
CAI21091      910 LENKVTD 916  zebrafish
ACM48164     1840 LENKVTD 1846 zebrafish
CAG08638      721 LENKVTD 727  spotted green pufferfish
XP_003770851 2103 LENKVTD 2109 Tasmanian devil
XP_423623    1833 LENKVTD 1839 chicken
XP_003448161 1858 LENKVTD 1864 Nile tilapia

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