Conserved Protein Domain Family
RasGAP_plexin_B3

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cd12791: RasGAP_plexin_B3 
Ras-GTPase Activating Domain of plexin-B3
Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Statistics
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PSSM-Id: 213351
Aligned: 12 rows
Threshold Bit Score: 723.553
Created: 1-Aug-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Rap
Feature 1:putative Rap interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                   #     
NP_005384    1327 GIPFLDYRTYAERAFFPGHggcplqpkpegpgedghCATVRQGLTQLSNLLNsKLFLLTLIHTLEEQPSFsQRDRCHVAS 1406 human
Q9QY40       1307 GIPFLDYRTYAERAFFPGHvgcplqpgleglgeegrSVTVRQGLTQLSNLLNsKLFLLTLIHTLEEQPSFsQRDRCHVAS 1386 house mouse
XP_003462229 1385 GIPFLDYGTYAERAFFPGHsgcplqpklegpgeeghRATVHQGLTQLSNLLNsKLFLLHLIHTLEEQPSFsQRDRCHVAS 1464 domestic guin...
CAQ14724      527 GIPFLDYRTYAERVFFPGQkgaplsqn--ldlpdsrRQTVEQGLSQLNNLLNnRLFLIRFIHTLEAQQSFsQRDRGYVAS 604  zebrafish
XP_003421777 1342 GIPFLDYHTYAERVFFPGHggcplqpwpngpeeearHATVRQGLTQLSHLLNsRLFLLTLIHTLEEQPSFsQRDRCHVAS 1421 African savan...
XP_003774752 1300 GIPFLDYKTFTERVFFPGHhgsplrse--idvpdarQATVKQGLNQLANLLNsKLFLIKFIHTLEEQPTFsQRDRCYVAS 1377 Tasmanian devil
XP_580392    1467 GIPFVDYRTYTERVLFPGRsggtlqpaveglgeeghRAPVHQGLMQLSNLLNsKLFLLTLIHTLEGQPSFsQRDRCHVAS 1546 cattle
XP_003216907 1360 GIPFLDYNTYTQRVFFPAQgdvplrrv--ldlpegrRATVEQGLGQLSNLLNsKVFLLTLIRTLEAQPTFsQRDRCHAAS 1437 green anole
XP_003457672 1322 GVPLLDYRIYAERVFFPGQqtaplsrq--ldlpesrRQTVEQGLQQLNNLLNnRLFLTRFIHTLEAQQGFsQRDRGYVAS 1399 Nile tilapia
XP_003802585 1346 GIPFLDYRTYARRAFFPGHggcplqpsqeepgeegrRATVRQGLTQLSNLLNsKLFLLTLIHTLEEQPSFsQRDRCHVAS 1425 small-eared g...
EGV92098     1183 GIPFLDYRTYAERAFFPGYggcplktglegpgeegrRATVCQGLTQLSNLLNsKLFLLTLIHTLEEQPSFsQRDRCHVAS 1262 Chinese hamster
XP_002935540 1257 GIPFLDYKTYVERIFFPVNidspipks--ldvpagrRSTVEQGLTQLSNLLNnKLFLTKLIETLDAQLTLsQRDRCHAAS 1334 western clawe...
Feature 1                                          #   #####      #                               
NP_005384    1407 LLSLALHGKleYLTDIMRTLLGDLAAHYVhRNPKLMLRRTETMVEKLLTNWLSICLYAFLREVAGEPLYMLFRAIQYQVD 1486 human
Q9QY40       1387 LLSLALHSKleYLTDIMRTLLGDLAAHYVhKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVD 1466 house mouse
XP_003462229 1465 LLSLALHGKleYLTDIMKTLLSDLAAHYVrKNPKLMLRRTETMVEKLLTNWLSICLYAFLREVAGEPLYMLFRAIQYQVD 1544 domestic guin...
CAQ14724      605 LLTMALHDKleYFTDVMKNLLGDLVQQYVaKNPKLMLRRTETVVEKMLTNWMSICLYSFLKEVAGEPLYKLYRAIKYQVD 684  zebrafish
XP_003421777 1422 LLSLALHGKleYLTDILKTLLGDLAAHYVdKNPKLMLRRTESMVEKLLTNWLSICLYAFLREVAGEPLYMLFRAIKYQVD 1501 African savan...
XP_003774752 1378 LLSLALHGKleYLTDIMKTLLSDLTAQYVhKNPKLMLRRTETMVEKLLTNWMSICLYSFLKEVAGEPLYMLFRAIKYQVD 1457 Tasmanian devil
XP_580392    1547 LLSLALHSKleYLTEIMRTLLSDLASHYVrKNPKLMLRRTETMAEKLLTNWVSICLYAFLREVAGEPIYMLLRAIQYQVD 1626 cattle
XP_003216907 1438 LLSLALHGRleYLTDIMQTLLSDLAAHCVsRNPKLMLRRTETMVEKLLTNWMSICLYSYLREVAGEPLYMLFRAIKYQVN 1517 green anole
XP_003457672 1400 LLTMALHDKleYFTEVMKSLLQDLVQQYVaKNPKLMLRRTETVVEKMLTNWMSICLYSFLKEVAGEPLYMLYRAIKYQVD 1479 Nile tilapia
XP_003802585 1426 LLSLALHGKleYLTDIMRTLLGDLTAHYIhKNPKLMLRRTETMVEKLLSNWLSICLYTFLREVAGEPLYMLLRAIQYQVD 1505 small-eared g...
EGV92098     1263 LLSLALHSKleYLTDIMRTLLGDLAAHYVhKNPKLMLRRTETMVEKLLTNWLSICLYAFLKEVAGEPLYMLFRAIKYQVD 1342 Chinese hamster
XP_002935540 1335 LLTVALHGKleYLTDVMKTLLANLIDQCVaKNPKLLFRRTETIVEKLLTNWMSICLQTDLREAAAEPLYMLYCAIKYQVD 1414 western clawe...
Feature 1                                                                                         
NP_005384    1487 KGPVDAVTGKakrtlndsrllredvefqpltlmvlvgpgaggaagssemqrvparvldtdtitqvkekvldqvykgtpfs 1566 human
Q9QY40       1467 KGPVDAVTGKakrtlndshllredvefqpltlmalvgpeadraagnsgvhrvparvldtdtitqvkekvldqiykgtpfs 1546 house mouse
XP_003462229 1545 KGPVDAVTGKakrtlndshllredvefrpltlmvlvgpgagvatggevqrvparvldtdtitqvkekvldqiykgtpfsq 1624 domestic guin...
CAQ14724      685 KGPVDAVTGKakrtlndshllredidycavtltvlvksgvevqpcpvkvldidtitqvkdkildqiykgaafsqrpaads 764  zebrafish
XP_003421777 1502 KGPVDAVTGKakrtlndsrllredvefrpltlmvlagtsrmagtssgqcvparvldtdtitqvkekvldqvykgtpfsqr 1581 African savan...
XP_003774752 1458 KGPVDAVTGKakrtlndsrllredvefwpltltvlvgpatgtgepqrvparvlntdtitqvkekvldqiykgtpfsqrps 1537 Tasmanian devil
XP_580392    1627 KGPVDAVTGKakrtlndsrllredvefraltlmvlaspgpggplrsntalhiptrvldtdtitqvkekvldqiykgtpfs 1706 cattle
XP_003216907 1518 KGPVDAVTGKakrtlndgrllredveyrpltltvlvrgagpsggsetqripvrvldtdtitqvkekildqvykgvpfsqr 1597 green anole
XP_003457672 1480 KGPVDAVTGKakrtlndshllredieycsvtltvlvkngvevqpcpvkvldtdtitqvkdkildqvyrgapfsqrpsads 1559 Nile tilapia
XP_003802585 1506 KGPVDAVTGKakrtlndsrllredvefqpltlmvsvgpgtsgaavgnevqhvparvldtdtitqvkekvldqvykgtpfs 1585 small-eared g...
EGV92098     1343 KGPVDAVTGKakrtlndshllredvefrpltlmtlvgpgtygtagnsevqrmpvrvldtdtitqvkekvldqvykgtpfs 1422 Chinese hamster
XP_002935540 1415 KGPVDAVTGKakrtlndchllredidyhpmtltvivksgrethhvpvrvldtdtitqvkqkilnqvykgtpfsqrpaatt 1494 western clawe...
Feature 1                                                                                         
NP_005384    1567 qrpsvhaldlewrsglaghltls---dedltsvtqnhwkrlntlqhykvpdgatvglvpqlhrgstisqslaqrcplgen 1643 human
Q9QY40       1547 qrpsvhsldlewrsglaghltlsdedltsvtqnhwkrlntlqhykvpdgatvvlipqvhnggtvsqslgqtgcpsgentp 1626 house mouse
XP_003462229 1625 rplvhtldlewrsglaghltls----dedltsvtqnqwkrlntlqhykvpdgatvglipqlhnggaisqnpaqscpsgen 1700 domestic guin...
CAQ14724      765 ldlewrsgqaghltls----------------dddvtaivqgrwkrintlqhykvpdgatvaliprsqsslgvnqvyqtg 828  zebrafish
XP_003421777 1582 psvhtldlewrsgmaghltlsde---dltsvtqnhwkrlntlqhykvpdgatvglipqlhhigtitqspvqscpsgentp 1658 African savan...
XP_003774752 1538 vhaldlewrsgvaghltlsd---------edltsvtqnqwkrlntlqhykvpdgatvgliprmhngssiskspnqsflsg 1608 Tasmanian devil
XP_580392    1707 qrpsahtldlewrsglaghltlsdedvtsvtqnrwkrlntlqhykvpdgatvrlipqlhngggiisqslapscpsgentp 1786 cattle
XP_003216907 1598 psvhsldlewrsgvaghltl--------sdedltsvtqkewkrlntlqhykvpdgatvgliprlhndisqgtgqsffsge 1669 green anole
XP_003457672 1560 ldlewrsgqaghltlsd--------------ddvtavvqgrwkrlntlqhykvpdgatvaliprsqssggvgvnqvfqtg 1625 Nile tilapia
XP_003802585 1586 qrpsvhaldlewrsglaghltls---dadltsvtqnhwkrlntlqhykvpdgatvalipqpqdssttpwgqghscpsgen 1662 small-eared g...
EGV92098     1423 qrpsvhsldlewrsglaghltlsdedltsvtqnhwkrlntlqhykvpdgatvvlipqlhnggtvsqrlgqtgcpfgentp 1502 Chinese hamster
XP_002935540 1495 ldlewrsgnaghltlsd--------------edltsliqdqwkrlntlhhykvpdnatvaliprlhnnqcetpsnsfigg 1560 western clawe...
Feature 1                                                                                         
NP_005384    1644 iptledgeeggvclwhlvkateepegakvrcsslrerePARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPIPI 1723 human
Q9QY40       1627 mledgeeggvrlwhlvkateeaegakvrrsslrdrereRSRAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSMNRPVPI 1706 house mouse
XP_003462229 1701 ipmledgeeggvrlwhlvkateepegakaprsslqereRARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPVPL 1780 domestic guin...
CAQ14724      829 ektpmlegeeeeglrlwhlvkptedpeipkhrkssmreRERAKAIPEIYLTRLLSMKGTLQKFVDDVFVAILSTKRPPPI 908  zebrafish
XP_003421777 1659 mledseegglrlwhlvkateepegtkprrsslrerereRARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPVPI 1738 African savan...
XP_003774752 1609 eslpmledgdesgirlwhlvksteepevakqrrsslrdRERAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVDRPVPI 1688 Tasmanian devil
XP_580392    1787 mledseeggvhlwhlvkapeepeaakarrsslrdrdreRARAKAIPEIYLTRLLSMKGTLQKFVDDAFQAILSVNRPVPI 1866 cattle
XP_003216907 1670 ntpmledgeeggvrlwhlvkpseepeptkqqqdrrsslRERAKAIPEIYLTRLLSMKGTLQKFVDDAFQAVLSVNRPVPI 1749 green anole
XP_003457672 1626 ektpmlegeeeeglrlwhlvkssedpeipkhrkssmreRERAKAIPEIYLTRLLSMKGTLQKFVDDVFVAILSTKRPPPI 1705 Nile tilapia
XP_003802585 1663 iptledgeeggvrlwhlvkateepeeakvwrsslqeweQARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNQPVPI 1742 small-eared g...
EGV92098     1503 mledgeeggvrlwdlvkateepegakvqrsnlrerereRARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPVPI 1582 Chinese hamster
XP_002935540 1561 ektpmledgdeggirtwhlvkpveepevfknrksslreRERAKAIPEIFLTRLLSMKGTLQKFVDDAFQVMLGVNRQVPI 1640 western clawe...
Feature 1                                                                        #       ##  ##   
NP_005384    1724 AVKYLFDLLDELAEKHGIed--------------------------------------pGTLHIWKTNSLLLRFWVNALK 1765 human
Q9QY40       1707 AVKYLFDFLDELAEKHGIed--------------------------------------pETLHIWKTNSLLLRFWVNVLK 1748 house mouse
XP_003462229 1781 AVKYLFDFLDELAEKLGIed--------------------------------------pETLHIWKTNSLLLRFWVNALK 1822 domestic guin...
CAQ14724      909 AVRFFFDFLDDMAEKHGIdd--------------------------------------pETVHIWKTNSLPLRFWVNILK 950  zebrafish
XP_003421777 1739 AVRYLFDFLDELAEKHGIdd--------------------------------------pDTLHIWKTNSLLLRFWVNTLK 1780 African savan...
XP_003774752 1689 AVKYLFDFLDELADKHGIed--------------------------------------qETLHIWKTNSLLLRFWVNTLK 1730 Tasmanian devil
XP_580392    1867 AVKYLFDFLDELAEKHSIed--------------------------------------pETLHIWKTNSLLLRFWVNTLK 1908 cattle
XP_003216907 1750 AVKYLFDLLDELAVQHGVne--------------------------------------pETLHIWKTNSLLLRFWVNTLK 1791 green anole
XP_003457672 1706 AVRFFFDFLDDMAEKHGIdd--------------------------------------pETVHIWKTNSLPLRFWVNILK 1747 Nile tilapia
XP_003802585 1743 AVKYLFDFLDELAEKHGIgd--------------------------------------aETLHIWKTNSLLLRFWVNVLK 1784 small-eared g...
EGV92098     1583 AVKYLFDFLDELAEKHGIedpetlhiwktnrsptpgqtsyveewgeevqgeeatmegqaSSPHLTCTSSLLLRFWVNALK 1662 Chinese hamster
XP_002935540 1641 AIKYFFDFLDEMAEKHEItd--------------------------------------aETVHIWKTNSLMLRFWVLILK 1682 western clawe...
Feature 1                               #      # #      ##                                        
NP_005384    1766 NPQLIFDVRVSDNVDAILAVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQsspaSYQEMNSAL 1845 human
Q9QY40       1749 NPQLIFDVQVSDNEDAILAVIAQTFIDSCMVSEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIRQsspaSYQEMNSAL 1828 house mouse
XP_003462229 1823 NPQLIFDVHVSDNVDAILAVIAQTFIDACTISEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIRHsspaSYQEMNSAL 1902 domestic guin...
CAQ14724      951 NPQFVFDVQVTDSVDPVLSVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQLVERYYSDIHNavsgCYQEMNSML 1030 zebrafish
XP_003421777 1781 NPQFIFDVRVSDNVDAILAVIAQTFIDSCTVSEHKVGRDSPVNKLLYAREIPRYKQMVEKYYTDIREsspaSYQEMNSAL 1860 African savan...
XP_003774752 1731 NPQFIFDVRVSDNVDAILTVIAQTFIDSCTISEHKVGRDSPVNKLLYAREIPRYKQMVEKYYSDIRQnttaSYQEMNSAL 1810 Tasmanian devil
XP_580392    1909 NPQLIFDVRVSDNVDAVLAVIAQTFMDSCTVSEHKVGRDSPVNKLLYAREIPRYKQMVERYYSDIRQsppaSYQEMNSAL 1988 cattle
XP_003216907 1792 NPQFIFDVRVSDNVDANLSVIAQTFIDACTTAEHKVGRDSPVNKLLYAREIPHYKQMVEKYYADIRQtvpaSYQEMNSAL 1871 green anole
XP_003457672 1748 NPQFVLDVQVTDSIDAVLSVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQLVERYYSDIHSaasgCYQEMNSTL 1827 Nile tilapia
XP_003802585 1785 NPQLIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVGRDSPVNKLLYAQEIPRYKQMVEKYYADIRQsspaSYQEMNSAL 1864 small-eared g...
EGV92098     1663 NPQLTFDVRVSDNEDAILAVIAQTFIDSCVISEHKVGRDSPVNKLLYAREIPCYKQMVEKYYADIHQsspvSYQEMNSTL 1742 Chinese hamster
XP_002935540 1683 NPQMVFDVEVSENVDSILAVIAQTFIDSCTISEHKVGRDSPVNKLLYAREIPRYKQLVENYYADIKKtaaaSYQEMNSFL 1762 western clawe...
Feature 1                                                                        
NP_005384    1846 AELSGNYTsaPHCLEALQELYNHIHRYYDQIISALEEDPVGQKLQLACRLQQVAALVENKVTD 1908 human
Q9QY40       1829 AELSGNYSsaPHCLEALRELYNHIHRYYDQIISALEEDPVAQKMQLACRLQQVAALVEYKVTD 1891 house mouse
XP_003462229 1903 AELSGNYTsaPHCLEALQELYNHIHRYYDQIISALEEDPVGQKMQLACRLQQIAALVENKVTD 1965 domestic guinea pig
CAQ14724     1031 TELSGSFAseMNSLVALHELYKYINKYYDQIIMSLEEDAAGQKMQLAYRLQQVAALVENKVTD 1093 zebrafish
XP_003421777 1861 AELSGSYTsaPHCLEALQDLYKHIHRYYDQIISALEEDPMGQKMQLACRLQQIAALVENKVTH 1923 African savanna elephant
XP_003774752 1811 TELSGNYAsdITCLVALHELYNYINKYYDQIISALEEDPVGQKMQLAYRLQQIAALVENKVTD 1873 Tasmanian devil
XP_580392    1989 TELSGNYTsaPHCLQALQELYTHIHRYYDQIIGALEEDPVGQKMQLACRLQQMAALVENKVTE 2051 cattle
XP_003216907 1872 TELSGKYSsdLNCLVALQELYNYINKYYDQIIFALEEDPLGQKMQLAYRLQQIAALVENKVTD 1934 green anole
XP_003457672 1828 TELSGSFAseMNNLVALHELYKYINKYYDQIIMSLEEDSSGQKMQLAYRLQQVAALVENKVTD 1890 Nile tilapia
XP_003802585 1865 AELSGSYTsaPHCLEALQGLYHHIHRYYDQIISALEDEPVGQKVQLACRLQHIAALVENKVTD 1927 small-eared galago
EGV92098     1743 AELSGNYTsaPHCLEALQELYNHIHRYYDQIISALEEDPVAQKMQLACRLQQIAALMENKVTD 1805 Chinese hamster
XP_002935540 1763 TEQSGVHSteLNSLVALQELYNYINKYYDQISSALEEDPNGQKMQLAYRLQQISALVENKVTD 1825 western clawed frog

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