3RYT,3IG3


Conserved Protein Domain Family
RasGAP_plexin_A
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cd12790: RasGAP_plexin_A 
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Ras-GTPase Activating Domain of type A plexins.
Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Links
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Statistics
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PSSM-Id: 213350
Aligned: 24 rows
Threshold Bit Score: 522.37
Created: 1-Aug-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative Rap
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Rap interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       # 
3RYT_A         48 GIPFLDYRTYAMRVLFPGIedhpvl------kemevQANVEKSLTLFGQLLTk----KHFLLTFIRTLEAQRSFsmRDRG 117  house mouse
NP_726627     913 GIPFLDYRSYAMKILFPNHedhivl-----qwerpeLLRKEKGLRIFGQLIMn----KTFLLLFIRTLESNRYFsmRERV 983  fruit fly
XP_002404755 1334 GIPFLDYRAYTMKVLFPNVedhpvlrd--mqmdpvkKQYMEKGLWHFGQLVMn----KTFLLLFIRTLESNRYFsmRDRV 1407 black-legged ...
EFX81191     1353 GIPFLDYRTYAMKILFPSMeehtll-----qwerpdMLRKDKPLRLFGQLLMn----KTFLLLFIRTLESNRYFymRDRV 1423 common water ...
NP_500018    1333 TAPFLEYKDYCARVLFPNAgknhavlk-nlevdthkAEAIEAGLREFHKLLMn----KTFLLTMVRTMEANKYFvgKDRV 1407 nematode
XP_002125244  773 GIPYLEYRVYLMRVLFPDPltaeqqhtlllsdyrtnSVRQGRGRTIGMERFNrllenKVFMMSLIRCLEQQRGFsmKDKG 852  Ciona intesti...
XP_003724035  750 GIPFHSYHIYAMKTMFPDQpnhpvlre--lplprdrKTNCERGLQMFGQLIDn----KTFLLCLIQTLEEQRTFnlRDVS 823  purple urchin
NP_001081382 1308 GIPFLEYRTYAMRVLFPGIedhpvl------kemevQANVEKSLTLFGQLLTk----KHFLLTFIRTLEAQRSFsmRDRG 1377 African clawe...
NP_115618    1318 GIPFLDYRTYAMRVLFPGIedhpvl------kemevQANVEKSLTLFGQLLTk----KHFLLTFIRTLEAQRSFsmRDRG 1387 human
XP_003642027 1311 GIPFLDYRTYAMRVLFPGIedhpvl------kemevQANVEKSLTLFGQLLNk----KHFLLTFIRTLEAQRSFsmRDRG 1380 chicken

Feature 1                                                #   #####      #                         
3RYT_A        118 NVASLIMTALQgemEYATGVLKQLLSDLIEKNLesknhPKLLLRRTESVAEKMLTNWFTFLLYKF-LKECAGEPLFMLYC 196  house mouse
NP_726627     984 NVASLIMVTLQsklEYCTDILKTLLGDLIEKCIegkshPKLLLRRTESVAEKMLSAWFTFLLYKF-LKECAGEPLYMLFR 1062 fruit fly
XP_002404755 1408 SVASLIMVTLQgkmEYCTDILKTLLAELIEKCIegkshPKLLLRRTESVAEKMLSAWFTFLLYKF-LRECAGEPLFVLYR 1486 black-legged ...
EFX81191     1424 NVASLIMVTLQskmEYCTDILKTLLAELIEKCMegkshPKLLLRRTESVAEKMLSAWFTFLLYKF-LRECAGEPLYLLFR 1502 common water ...
NP_500018    1408 YVGSLLMVVLQekmGYCTEMLKQLLRELIEKTVekkfqPKILFRRSESIAERMLAAWFTFLLHDHlKTYDAGKKLYELFW 1487 nematode
XP_002125244  853 TVAGLIMVIFQdrlHYATEILEQLLADLIRKNMesrnhPKLLLRRTESVAEKMLTHWFSILLYRF-VVECAGEPLFMLCR 931  Ciona intesti...
XP_003724035  824 AVASLLMVVLQskmDYATDIMKVLLERLIEKHLek-drARLLMRRNESVAEKMVSNWLSFLLYNF-LVDSAGEPLFTLFY 901  purple urchin
NP_001081382 1378 NVASLIMTALQgemEYATGVLKQLLSDLIEKNLesknhPKLLLRRTESVAEKMLTNWFTFLLYKF-LKECAGEPLFMLHC 1456 African clawe...
NP_115618    1388 NVASLIMTALQgemEYATGVLKQLLSDLIEKNLesknhPKLLLRRTESVAEKMLTNWFTFLLYKF-LKECAGEPLFMLYC 1466 human
XP_003642027 1381 NVASLIMTALQgemEYATGVLKQLLSDLIEKNLesknhPKLLLRRTESVAEKMLTNWFTFLLYKF-LKECAGEPLFMLYC 1459 chicken

Feature 1                                                                                         
3RYT_A        197 AIKQQMEKGPIDAItgearyslsedklirqqidyktltlncvnpehenapevpvkglncdtvtqvkeklldavykgvpys 276  house mouse
NP_726627    1063 AVKGQVDKGPVDACthearyslseeklirqsidfrpmnvyasiiqqpifcnnldmlpshtenvsvkvldcdtigqvkekc 1142 fruit fly
XP_002404755 1487 AIKQQVDKGPVDAItsearyslseeklirqsieyksmtayisiaqqscympgmepigennetpvrildcdtvsqvkekgl 1566 black-legged ...
EFX81191     1503 AIKHQVDKGPVDCVtsearyslseeklirqsidykimtvyvsispqtiyvsgleahtdntdtpvkvldcdtivqvkdkal 1582 common water ...
NP_500018    1488 GIKQQMEKGPQDALtlearyslseekllratfeykelmvfvsasdsvysstqdipvrvldcdtitqvkekcldakyrgyr 1567 nematode
XP_002125244  932 AIRQQVDKGPVDMYtgearyslsedkllrqdvehrtitlrvnnylseldipdfavkvlscdsvsqvkrkildvaymnlpy 1011 Ciona intesti...
XP_003724035  902 GIKQQVEMGPIDSItgearyglsevkiirqtienktltiyamgldkdadplqvkvhtcdsisqvkekildsiyrttpysh 981  purple urchin
NP_001081382 1457 AIKQQMEKGPIDAItgearyslsedklirqqidyktlnpcaddvglsdesccrspqtlncvnpenenapeipvkvlncdt 1536 African clawe...
NP_115618    1467 AIKQQMEKGPIDAItgearyslsedklirqqidyktltlncvnpenenapevpvkgldcdtvtqakeklldaaykgvpys 1546 human
XP_003642027 1460 AIKQQMEKGPIDAItgearyslsedklirqqidykmltlncvnpenenapeipvkvlncdtitqvkeklldavykgvpys 1539 chicken

Feature 1                                                                                         
3RYT_A        277 qrpkagdmdlewrqgrmariilqdedvttk------------------------------------------------id 308  house mouse
NP_726627    1143 letiyrnipssqrprkddldlewrtgatgrvilyded----------------------------------vtsktesew 1188 fruit fly
XP_002404755 1567 davyknmpssqrpskddldlewrtgntgrlilsde---------------------------------------dsttka 1607 black-legged ...
EFX81191     1583 dtiyrstpysqrprkedldlewrtgtsgrlvlydedstskvegdwkklntlahyrvpdgalltlipkqssmynlsilsdq 1662 common water ...
NP_500018    1568 fadrpapgdmelewktgmngkmalqdidsssrv-------------------------------------------eggn 1604 nematode
XP_002125244 1012 sgrphpaevdiewrqtrgsvtlrdeepsanngdnlm-------------------------------------qvhtley 1054 Ciona intesti...
XP_003724035  982 rppkeeldlewrcglsgrkilpe--------------------------------------------------------- 1004 purple urchin
NP_001081382 1537 itqvkeklldavykgvpysqrpkagdmdlewrqgrmarii-----------------------------lqdedvttkid 1587 African clawe...
NP_115618    1547 qrpkaadmdlewrqgrmariilqdedvttk------------------------------------------------id 1578 human
XP_003642027 1540 qrpkagdmdlewrqgrmariilqdedvttk------------------------------------------------id 1571 chicken

Feature 1                                                                                         
3RYT_A        309 ndwkrlntlahyqvtdgssvalvpkqtsaynisnsstftkslsryesmlrtasspdslrsrtpmitpdlesgtklwhlvk 388  house mouse
NP_726627    1189 kklntlqhynvpdgaglslvpkqssiynfsilsdknekshkyetlniskytsssptfsragsplnndmhenglrywhlvk 1268 fruit fly
XP_002404755 1608 dgewkrmntlahykvsdganltlvakqssmynlsimsekmekshkyetlnfsmktspplsratsplnhdpetgykywhlv 1687 black-legged ...
EFX81191     1663 hrggggggaadkghhhkyetlnlnlskfssasppmsratspmnhhhgdrshgggggghgthdrggdqdpsvkvwhlvrhh 1742 common water ...
NP_500018    1605 wkrlntlahynvpnnailtltsksnslynlsilsdrsekssvsmktpgvgspkpwgappsviadhasssadtdngfklyh 1684 nematode
XP_002125244 1055 yqisdgshvsiiprkhnsllnhsmmsstsktsnhkhngsgarlfqttdgsntslprykqtsrsgtptlmqdgtkfyhlvk 1134 Ciona intesti...
XP_003724035 1005 -----dngavdgdwkrltmlsdeqvrdgdtialvpkqgftmsaftspttgrytaspcrsttpmlgssdvenglklwhlvk 1079 purple urchin
NP_001081382 1588 ndwkrlntlahyqvtdgssvalvpkqnsaynisnsstftkslsryesmlrtasspdslrsrtpmitpdlesgtklwhlvk 1667 African clawe...
NP_115618    1579 ndwkrlntlahyqvtdgssvalvpkqtsaynisnsstftkslsryesmlrtasspdslrsrtpmitpdlesgtklwhlvk 1658 human
XP_003642027 1572 ndwkrlntlahyqvtdgssvalvpkqnsaynisnsstftkslsryesmlrtasspdslrsrtpmitpdlesgtklwhlvk 1651 chicken

Feature 1                                                                                         
3RYT_A        389 nhdhldqregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsaLPLAIKYMFDFLDEQADKHQIhdsDVRH 468  house mouse
NP_726627    1269 hhdsdmqkegervnKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsaLPLAIKYMFDFLDDQAQLHGItdpEVVH 1348 fruit fly
XP_002404755 1688 khhdgenkegergnKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsaLPLAIKYMFDFLDDQALQHGItdpEVVH 1767 black-legged ...
EFX81191     1743 dhdnsrkdgdqrgnKMVSEIYLTRLLSTKITLQKYVDDLFETIFSIANrgsaLPLAIKYMFDFLDDQALQHGItdpEVVH 1822 common water ...
NP_500018    1685 lvkptehgptdsqeKMVTEIYLTRLLMMKGTLAKFITSLLESIFSSST----VPPCIKYMFDFMDEQAREHGIndpEVVH 1760 nematode
XP_002125244 1135 pgdqdqregndrtnKMVSEIYLTRLLTTKGTIQKYVDDLFETVFSVVQrghaLPLAVKHMFDFLDHQADIHGItdpETVH 1214 Ciona intesti...
XP_003724035 1080 qsdhdntkgnekdhKMMAEIYLPRLLTTKVTLQKFVDDLFETIFSVNYrsntLPRAIKYLFDFFEDQAKQHGItnpEVVH 1159 purple urchin
NP_001081382 1668 nhdhldqregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsaLPLAIKYMFDFLDEQADKHQItdyDVRH 1747 African clawe...
NP_115618    1659 nhdhldqregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsaLPLAIKYMFDFLDEQADKHQIhdaDVRH 1738 human
XP_003642027 1652 nhdhmdqregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsaLPLAIKYMFDFLDEQADKHQIndyDVRH 1731 chicken

Feature 1         #       ##  ##                         #      # #      ##                       
3RYT_A        469 TWKSNCLPLRFWVNVIKNPQFVFDIHKnsITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYA 548  house mouse
NP_726627    1349 TWKSNSLPLRFWVNLIKNPNFVFDIHKsnIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYR 1428 fruit fly
XP_002404755 1768 TWKSNSLPLRFWVNLIKNPNFVFDIVKsnIVDSCLSVVAQTFMDACSTSDHRLGKDSPSSKLLYAKDIPVYKDWVERYYQ 1847 black-legged ...
EFX81191     1823 TWKSNSLPLRFWVNLIKNPNFVFDVHKsnIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLFAKDIPVYKEWVERYYA 1902 common water ...
NP_500018    1761 AWKSNALPLRFWVNLIKNPHFLFDIQKptKIEGCLSVVAQTLMDACSTQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYT 1840 nematode
XP_002125244 1215 TWKSNCLPLRFWVNLIKNPEFLYDINKspIVDCYLSVIAQTFMDSCSTAEHKLGKDSPSNKLLYAKDIPAYKGWVERYYS 1294 Ciona intesti...
XP_003724035 1160 SWKSNSLPLRFWVNLIKNPHHIFDIYKsdTVDACLSIVGQCLMDACSVSEHQLTKDSPSSKLLYAKDIPKYKEWVARYYD 1239 purple urchin
NP_001081382 1748 TWKSNCLPLRFWVNVIKNPQFVFDIHKnsITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYA 1827 African clawe...
NP_115618    1739 TWKSNCLPLRFWVNVIKNPQFVFDIHKnsITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYA 1818 human
XP_003642027 1732 TWKSNCLPLRFWVNVIKNPQFVFDIHKnsITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYA 1811 chicken

Feature 1                                                                                  
3RYT_A        549 DIAKMPaISDQDMSAYLAEQSRLHlsQFNSMSALHEIYSYIAKYk-DEILVALEKDEqarRQRLRSKLEQVVD 620  house mouse
NP_726627    1429 DIRDMSpISDQDMNAMLAEESRLHttEFNTNCALHELYTYAVKYn-EQLTVTLEEDEfsqKQRLAFKLEQVHN 1500 fruit fly
XP_002404755 1848 DIKVMPaISDQDMNAMLAEESRLHahEFNTNVALHELYKYAYKYt-DQLLQTLEEDEfsqKNRLAWKLGQVNS 1919 black-legged tick
EFX81191     1903 DIKTMAaISDQDMNAMLAEESRQHtvDFNVNCALQELYNYADRYy-EQLMMALEEDEfsqKQRLAYRLEQVRN 1974 common water flea
NP_500018    1841 EISMTPrIDDATMGANLSAESRQHngEFHVFSALNELYKYLDQYk-ESIIDALESNEhaqASRLPGRLQDLLA 1912 nematode
XP_002125244 1295 DISNMPqLNHKDMSAFLAEESFIHqnEFNTSAALTQFFGYVQKYs-GELLHILSVDPeaqRQRLFEQLEDVSV 1366 Ciona intestinalis
XP_003724035 1240 DIKNMPpISDQDMNAVLAEHSNGHqyDFHTLSALNELYHTYAKKygEQISESLQKDEfglKYKLAEKFEHVEQ 1312 purple urchin
NP_001081382 1828 DIAKMPvISDQDMSAYLAEQSRLHlsQFNSMSALHEIYSYITKYr-DEILTALEKDEqarRQRLRSKLEQVID 1899 African clawed frog
NP_115618    1819 DIAKMPaISDQDMSAYLAEQSRLHlsQFNSMSALHEIYSYITKYk-DEILAALEKDEqarRQRLRSKLEQVVD 1890 human
XP_003642027 1812 DIAKMPaISDQDMSAYLAEQSRLHlsQFNSMSALHEIYSYITKYk-DEILAALEKDEqarRQRLRSKLEQAID 1883 chicken

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