Conserved Protein Domain Family
RasGAP_plexin_C1
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cd12789: RasGAP_plexin_C1 
Ras-GTPase Activating Domain of plexin-C1
Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Links
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Statistics
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PSSM-Id: 213349
Aligned: 6 rows
Threshold Bit Score: 661.944
Created: 1-Aug-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Rap
Feature 1:putative Rap interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
Q9QZC2       1016 FGTVPFLDYKHFALRTFFPESggfthift-------edmhnrdANDKNESLTALDALICnKSFLVTVIHTLEKQKNFsvK 1088 house mouse
XP_003431068 1330 FGTVPFLDYKHFALRTFFPESgdfthify-------edihgrdTSDKNESLIALDGLICnKSFLVTVIHTLEKQKNFsvK 1402 platypus
XP_003221124  684 FGTVPFLDYKHFVLRTFFPERr--------------------nPDQKDEIITKLSKLICnKKFLVSLIHTLEKQKTFsvK 743  green anole
XP_416143     907 FGTVPFLDYKHFAIRTFFPESggfasifs------edmpqsrdQTRKDESFNMLHALICnKNFLVTLIHTLEKQKNFsvK 980  chicken
XP_002935372  873 VGTIPFLDYKHFALRTFLPEIeeskndftekmyenvpspfrnrTVDENEHLHLLRKLFEkKRFLVHLIHTLEHQSNFsvR 952  western clawe...
CAI21367      496 VGAIPFLDYKHFASRIFFPEAgtltavmi------rdigedseQTTVDEKCLAFAELIRdKQFLSCFVHALEEQKNFsiK 569  zebrafish

Feature 1          #                                      #   #####      #                        
Q9QZC2       1089 DRCLFASFLTIALQtklVYLTSILEVLTRDLMEQCSnmQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVT 1168 house mouse
XP_003431068 1403 DRCLFASFLTIALQtklVYLTNILEVLTKDLMEQSSnlQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVT 1482 platypus
XP_003221124  744 DRCLFASFLTIALQtnlVYLTDILELLTRDLMDQSSniQPKLLLRRTESVVEKLLTNWMSVCLSTFLRETVGEGFYLLVT 823  green anole
XP_416143     981 DRCLFASFLTIALQtklVYLTHILEVLTKDLMEQSSnvQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETIGEPFYLLVT 1060 chicken
XP_002935372  953 DRCRFASFLTISFQsnlVYLTELLEVLIKDLMDQSSnkQPKLMLRRTESVVEKLLTNWMSTCLYGYLRDLNVYFPNGSEE 1032 western clawe...
CAI21367      570 DKCTVASLLTLALHgdlLYLTEIMEDLLQSLMDQSSnaNPKLLLRRTESIVEKLLTNWMSICLYGFLRESVGQPLFLLVS 649  zebrafish

Feature 1                                                                                         
Q9QZC2       1169 TLNQKINKGPVDVItckalytlnedwllwqvpefntvalnvvfekipenesadvcrnisvnvldcdtigqakekvfqafl 1248 house mouse
XP_003431068 1483 TLNQKINKGPVDVItckalytlnedwllwqvpdfntvqyypggvhfygggkngqhpvwiifwlffdmekvswsncfrald 1562 platypus
XP_003221124  824 TLNQGIMKGPVDVItckalytlnedwllwqvtdfktvilnvvfeniqenesegitknievsvldcdtigqakekilqafl 903  green anole
XP_416143    1061 TLNQKINKGPVDAItckalytlnedwllwqvsefktvtvnvifekipenesgdacqtiqvnvldcdtigqtkekslqafl 1140 chicken
XP_002935372 1033 NVTESIKVTVLDCDtvgqakekivqkffikkgynwgfplhdtglvlhhgqlqkqlsdidntsvvlengiik--------- 1103 western clawe...
CAI21367      650 ALTQQISKGPVDSVtekalytlsedwllcqaqdfeplklkvvfavgtgeeiseslevialtcdtiqqvkekilqtfqrkf 729  zebrafish

Feature 1                                                                                         
Q9QZC2       1249 skngspyglqlneigle--------------------------------------------------------------- 1265 house mouse
XP_003431068 1563 ttkesgygisstnqwnflgtllgsskyiqfscntgvmlknptmlrrnlavilnvstitgrsaavspkpphlfcrwtddrp 1642 platypus
XP_003221124  904 skngslyglqlsemgla--------------------------------------------------------------- 920  green anole
XP_416143    1141 nkngfpyglqldeigle--------------------------------------------------------------- 1157 chicken
XP_002935372      --------------------------------------------------------------------------------      western clawe...
CAI21367      730 gfrytqqirdieieyek--------------------------------------------------------------- 746  zebrafish

Feature 1                                                                                         
Q9QZC2       1266 --lqvgtrqkelldidsssviledgitklntighyeisngstikvfkkianftsdveysddhchlilpdseafqvvqgkr 1343 house mouse
XP_003431068 1643 liqlqldgcqkelldidnssvtledgimklntighyeisngatlsvfkkinftsdmeysdehchlilpdseafqdvqgkr 1722 platypus
XP_003221124  921 --lqsgaytkelldvdsssvtledgitklntighyeifneatikvfkkektvlsdeeysdaychlilpdseavkdvqgtk 998  green anole
XP_416143    1158 --lvseeqqrelldidgssemmedgirklntiahykiangatikvlkkktntrsdvdysdehchlilpdseankdmkgsg 1235 chicken
XP_002935372 1104 ----------------------------lntlkhykiedgvtvkviiqkncdvqdlensskychlvlpssqgseqiegee 1155 western clawe...
CAI21367      747 --egkfvmlqevddtseirghvtmlntlkhyqvgdgacikvitpkihaplktqnsvkddknfsikyfhlvdpdidtdlsn 824  zebrafish

Feature 1                                                                               #       ##
Q9QZC2       1344 hrgkhKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLR 1423 house mouse
XP_003431068 1723 hkgkhKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNNRAPVAIKYFFDFLDAQAELKKITDPDVVHIWKTNSLPLR 1802 platypus
XP_003221124  999 hkgkqKFKVKEMYLTKLLSTKIAVHSVVEKLFRSIWTLPNNKAPVAIKYFFDFLDAQAENKKITDPDVLHIWKTNSLPLR 1078 green anole
XP_416143    1236 hkgkqKFKVKEMYLTKLLSTKVAIHSVVENLFRSIWSLPNNKAPVAIKYFFDFLDAQAESKRITDPDVVHIWKTNSLPLR 1315 chicken
XP_002935372 1156 nqgkhKFQVKELYLTKLLSTKVAIHSSVEKLFRSIWTIPTNKPPTAVKYFFDLLDSQAEIKKITDLDVLHIWKTNSLPLR 1235 western clawe...
CAI21367      825 hpekkALKIKEMYLIKLLSTKVAVHSFVENLFKSIWGLPNNKAPLAVKYFFDFLDEQAERKKITDPDVLHIWKTNSLPLR 904  zebrafish

Feature 1           ##                          #      # #      ##                                
Q9QZC2       1424 FWVNILKNPQFVFDIK-KTPHIDSCLSVIAQAFMDAFSLTEQqlGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDlppLS 1502 house mouse
XP_003431068 1803 FWVNILKNPQFVFDIK-KTPHIDGCLSVIAQAFMDAFSLAEQqlGKEAPTNKLLYAKDIPNYKEEVKSYYKAIRDlppLS 1881 platypus
XP_003221124 1079 FWVNILKNPQFVFDIK-KTPHMDGCLSVIAQAFMDSFSLSEQqlGKEAPTNKLLYAKDIPRYKEEVKAFYKAIKDlppLS 1157 green anole
XP_416143    1316 FWVNILKNPQFVFDVK-KTSHIDGCLSVIAQAFMDAFSLAEQtmGKEAPTNKLLYAKDIPLYKKEVKAYYKAIRDlppLT 1394 chicken
XP_002935372 1236 FWVNILKNPQFVFDLK-KTHLLESCLSVIAQAFMDSFSISEQhlGKSSPTNKLLYAKDIPMFKEEVKNYYKGIRDappVS 1314 western clawe...
CAI21367      905 FWVNILKNPDFVFSDMeKSPHLDGCLSVIAQAFMDSFSLTDThlDKHSPTNKLLYGKDIPQYKQEVKSYYKLVKDqtsIS 984  zebrafish

Feature 1                                                                                
Q9QZC2       1503 SLEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYfDEILNKLERERGlEEAQKQLLHVKVLFDEKKKCKW 1573 house mouse
XP_003431068 1882 TSEIEEFLTQESKKHENEFNEEVALTEIYKYIIKYfDEIINKLERERGlEDARKQLLKVKDLFDEKKKCKW 1952 platypus
XP_003221124 1158 TSEIEDFLTQESKKHENEFNEAAALMKIYQYIAKYfDEILNKLEKERGlEEVQQQLLHIKSLVEEKKKCKW 1228 green anole
XP_416143    1395 TSEVEEFLTQESKKHENEFNEEVALMEIYRYIVKYyDEIVSKLERERGfEEVQKQLQQVKALFDEKKKCKW 1465 chicken
XP_002935372 1315 SAELNEFLMAESKKHENEFKEDVALLELYKYIKRYhQVVLDMLEKEPGfEDEQKQLLDITALMEDKKKCMW 1385 western clawed frog
CAI21367      985 SQELKTFLQEESKKHQNEFNESAALRELYKYMQRYfTEIFQKLEQTDApSNLKENMHRVKELFDNMKRSGW 1055 zebrafish

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