Conserved Protein Domain Family
RasGAP_plexin_D1
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cd12788: RasGAP_plexin_D1 
Ras-GTPase Activating Domain of plexin-D1
Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Links
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Statistics
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PSSM-Id: 213348
Aligned: 5 rows
Threshold Bit Score: 846.197
Created: 1-Aug-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Rap
Feature 1:putative Rap interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
Q9Y4D7    1344 QGIPFLEYKHFVTRTFFPKCsslyeeryvlp--------------------------sqtlnsqgssQAQETHPLLg-EW 1396 human
AAI68545  1358 QGIPFLEYKHFVTRTFFPKCsslyeeryilp--------------------------tqnfntqlgfQVPETHPLLcgEW 1411 western clawed frog
NP_991260 1299 QGIPFLEYKQFVTRTFFPKMccdyerrlvqp--------------------------vyendplgprAHSETHPLLq-DW 1351 zebrafish
XP_414455 1346 QGIPFLEYKHFVTRTFFPKCsslyeecyvlp--------------------------sqqlnsqvgsQVQETHPLLvgEW 1399 chicken
CAG11333   919 QGIPFLEYKQFVTRTFFPKLglfaslqlgfcltvvfllvswelsqmcsdyerslvqhayendgiaprVLPETHPLLq-DW 997  spotted green pu...

Feature 1                                                  #                                   
Q9Y4D7    1397 KIPESCRPNMEEGISLFSSLLNnKHFLIVFVHALEQQKDFavRDRCSLASLLTIALHGkleYYTSIMKELLVDLIDASAa 1476 human
AAI68545  1412 KVPENCRTNMEEGITLLSTLLNnRHFLVTFIHAVELQKDFavRDRCNLASHLTIALHGkleYYTSIMKDLLVDLIDSSAs 1491 western clawed frog
NP_991260 1352 QPAGSVRPNLEEGITLFSTLLNnKHFLVTFVHALEQQRDFavRDRCNLASLLTIALHGkleYYTSIMKDLLVDLIDASAt 1431 zebrafish
XP_414455 1400 KIPESCRPNMEEGISLFSTLLNnKHFLIVFVHALEQQKDFavRDRCNLASLLTIALHGkleYYTSIMKDLLVDLIDASAs 1479 chicken
CAG11333   998 QATNATRPNVEEGITLFSTLLNnKHFLVTFVHALEQQKDFavRDRCSLASLLTIALHGkleYYTSIMKDLLVDLIDASAs 1077 spotted green pu...

Feature 1         #   #####      #                                                             
Q9Y4D7    1477 kNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAItgkarytlseewllrenieakpr 1556 human
AAI68545  1492 kNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAItgkarytlneewllrenieakpm 1571 western clawed frog
NP_991260 1432 kNPKLMLRRTESVVEKMLTNWMSICMYSYLKETVGEPFFLLLCAIKQQINKGSIDVLtgkarytlneewllrenieakpq 1511 zebrafish
XP_414455 1480 kNPKLMLRRTESVVEKMLTNWMSICMYSYLRETVGEPFFLLICAIKQQINKGSIDAItgkarytlneewllrenieakpr 1559 chicken
CAG11333  1078 kNPKLMLRRTESVVEKMLTNWMSICMYSYLKETVGEPFFLLLCAIKQQINKGSIDAItgkarytlneewllrenvearpq 1157 spotted green pu...

Feature 1                                                                                      
Q9Y4D7    1557 nlnvsfqgcgmdslsvramdtdtltqvkekileafcknvpysqwpraedvdlewfasstqsyilrdlddtsvvedgrkkl 1636 human
AAI68545  1572 nlnvsfqgcgmdslcvrvldtdtvsqckekileafcknlpysqwprvedvdlewfasssksyilrdlddssimedgkkkl 1651 western clawed frog
NP_991260 1512 nvmvsfqglgmdsvcvrvmnsdticqvkekileafyknlpysqwpreedvelewfpegrssrilqdlddssvmedgrkkl 1591 zebrafish
XP_414455 1560 nlnvsfqgcgmdslsvramdtdtlsqvkekileafcknvpysqwprvedvdlewfatstdsyilrdlddtsvvedgrkkl 1639 chicken
CAG11333  1158 ninvsfqgcgmdslsvrvmhtdticqvkekiieafyknlpfsqwpraedvdlewldsggnskllqdldnssvmedgrkkl 1237 spotted green pu...

Feature 1                                                                                      
Q9Y4D7    1637 ntlahykipegaslamslidkkdntlgrvkdldtekyfhlvlptdelaepkkshrqshrKKVLPEIYLTRLLSTKGTLQK 1716 human
AAI68545  1652 ntlahykvhdgaslamslkdkrddtlgrvkdldtdkyfhlvlptddlaetkrshrqshrKKVLPEIYLTRLLSTKGTLQK 1731 western clawed frog
NP_991260 1592 ntvfhyqipdgaslamslkdkrentlgrvkdldtekyvhlvlphdelmesrkthrqsqrKKVLPEIYLTRLLSTKGTLQK 1671 zebrafish
XP_414455 1640 ntlahykipegaslamslsdkkdgtlsrvkdldtekyfhlvlptdesvehkkshrqshrKKVLPEIYLTRLLSTKGTLQK 1719 chicken
CAG11333  1238 ntvfhyqvpegaslamslkdkkentlgrvkdldtekyvhlvlphdelmetrkshrhshrKKVLPEIYLTRLLSTKGTLQK 1317 spotted green pu...

Feature 1                                                  #       ##  ##                      
Q9Y4D7    1717 FLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGIsDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKtDHIDACLS 1796 human
AAI68545  1732 FLDDLFRAILSIHEDRPPLAIKYFFDFLEEQAEKRGIsDPDTLHIWKTNSLPLRFWVNILKNPEFVFDMDKsDHMDACLS 1811 western clawed frog
NP_991260 1672 FLDDLFQAILSVPAENPPLAIKYFFDFLEEQADKRGItDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIEKtDHMDACLS 1751 zebrafish
XP_414455 1720 FLDDLFKAILSIRDDKPPVAVKYFFDFLEEQAEKRGItDPDTMHIWKTNSLPLRFWVNILKNPQFVFDIDKtDHIDACLS 1799 chicken
CAG11333  1318 FLDDLFQAILSIPLDRPPLAVKYFFDFLEEQADKRGItDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKtDHMDACLS 1397 spotted green pu...

Feature 1         #      # #      ##                                                           
Q9Y4D7    1797 VIAQAFIDACSISDLQlgKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMtpLSEQEMNAHLAEESRKyqNEFNTNVAMAE 1876 human
AAI68545  1812 VIAQAFIDACSISDMQlgKDSPTNKLLYAKEIPEYRKIVQRYYQKIKEMspLSEQEMNAHLAEESRKyrNKFNTNVAMAE 1891 western clawed frog
NP_991260 1752 VIAQAFIDACSLSDLQlgKDSPTNKLLYAKEIPEYKKRVQSFYRQIQELpaLSEQEMNTHLAEESRKhrNEFNTTLALTE 1831 zebrafish
XP_414455 1800 VIAQAFIDACSLSDLQlgKDSPTNKLLYAKEIPEYRKIVQRYYKQIHDMppLSEQEMNAHLAEESRKyrNEFNTNVAMAE 1879 chicken
CAG11333  1398 VIAQAFIDACSISDLQlgKDSPTNKLLYAKEIPEYKKRVQLYYQQIQEMapLSEQEMNAHLAEESRKyrNEFNTNLALTE 1477 spotted green pu...

Feature 1                                                      
Q9Y4D7    1877 IYKYAKRYRPQIMAALEANPTaRRTQLQHKFEQVVALMEDNIYECYSE 1924 human
AAI68545  1892 IYKYAKKYRTQIVTALETNPTtKRGQLQHKFDQVIVLMEDDIYSCSSE 1939 western clawed frog
NP_991260 1832 VYKYAKRYRAQVASALDSNPTaRRTQLQHKFEQVIALVEDNIYECSSE 1879 zebrafish
XP_414455 1880 IYKYAKRYRSQIVAALDSNPTtKRTQLQHKFEQVIALMEDNIYECCSE 1927 chicken
CAG11333  1478 IYKYAKRYRNQVVSALESNPTaRRTQLHHKFEQVIALVEDNIYECCSE 1525 spotted green pufferfish

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