3HM6


Conserved Protein Domain Family
RasGAP_plexin_B
?
cd12787: RasGAP_plexin_B 
Click on image for an interactive view with Cn3D
Ras-GTPase Activating Domain of type B plexins.
Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Links
?
Statistics
?
PSSM-Id: 213347
Aligned: 3 rows
Threshold Bit Score: 739.049
Created: 1-Aug-2012
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative Rap
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Rap interface [polypeptide binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                  #   
3HM6_X      71 GIPFLDYKVYAERIFFPGHresplhrd----lgvpesrRPTVEQGLGQLSNLLNsKLFLTKFIHTLETQRTFsaRDRAYV 146  human
O15031    1271 GIPVLDYKTYTDRVFFLPSkdgdkdvmitgkldipeprRPVVEQALYQFSNLLNsKSFLINFIHTLENQREFsaRAKVYF 1350 human
NP_005384 1327 GIPFLDYRTYAERAFFPGHggcplqpkp--egpgedghCATVRQGLTQLSNLLNsKLFLLTLIHTLEEQPSFsqRDRCHV 1404 human

Feature 1                                          #   #####      #                            
3HM6_X     147 ASLLTVALHGKleYFTDILRTLLSDLVAQYVa-KNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKH 225  human
O15031    1351 ASLLTVALHGKleYYTDIMHTLFLELLEQYVvaKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430 human
NP_005384 1405 ASLLSLALHGKleYLTDIMRTLLGDLAAHYVh-RNPKLMLRRTETMVEKLLTNWLSICLYAFLREVAGEPLYMLFRAIQY 1483 human

Feature 1                                                                                      
3HM6_X     226 QVDKGPVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltq 305  human
O15031    1431 QVEKGPVDAVQKKakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510 human
NP_005384 1484 QVDKGPVDAVTGKakrtlndsrllredvefqpltlmvlvgpgaggaagssemqrvparvldtdtitqvkekvldqvykgt 1563 human

Feature 1                                                                                      
3HM6_X     306 rpdprtldvewrsgvaghlilsd-------edvtsevqglwrrlntlqhykvpdgatvalvpcltkhvlrenqdyvpger 378  human
O15031    1511 dsvvlewrpgstaqilsd------------------ldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqq 1572 human
NP_005384 1564 pfsqrpsvhaldlewrsglaghltlsdedltsvtqnhwkrlntlqhykvpdgatvglvpqlhrgstisqslaqrcplgen 1643 human

Feature 1                                                                                      
3HM6_X     379 tpmledvdeggirpwhlvkpsdepepprprrgslrggereRAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPL 458  human
O15031    1573 dlpgerhalleeenrvwhlvrptdevdegkskrgsvkekeRTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPP 1652 human
NP_005384 1644 iptledgeeggvclwhlvkateepegakvrcsslrerepaRAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPIPI 1723 human

Feature 1                               #       ##  ##                         #      # #      
3HM6_X     459 AVKYFFDLLDEQAQQHGIsdqDTIHIWKTNSLPLRFWINIIKNPQFVFDVQtsdNMDAVLLVIAQTFMDACTLADHklgr 538  human
O15031    1653 AVKYFFDFLDEQAEKHNIqdeDTIHIWKTNSLPLRFWVNILKNPHFIFDVHvheVVDASLSVIAQTFMDACTRTEHklsr 1732 human
NP_005384 1724 AVKYLFDLLDELAEKHGIedpGTLHIWKTNSLLLRFWVNALKNPQLIFDVRvsdNVDAILAVIAQTFIDSCTTSEHkvgr 1803 human

Feature 1      ##                                                                              
3HM6_X     539 DSPINKLLYARDIPRYKRMVERYYADIRQtvpaSDQEMNSVLAELSWNysgdLGARVALHELYKYINKYyDQIITALEED 618  human
O15031    1733 DSPSNKLLYAKEISTYKKMVEDYYKGIRQmvqvSDQDMNTHLAEISRAhtdsLNTLVALHQLYQYTQKYyDEIINALEED 1812 human
NP_005384 1804 DSPVNKLLYAREIPRYKQMVERYYADIRQsspaSYQEMNSALAELSGNytsaPHCLEALQELYNHIHRYyDQIISALEED 1883 human

Feature 1                           
3HM6_X     619 GtaqKMQLGYRLQQIAAAVEN 639  human
O15031    1813 PaaqKMQLAFRLQQIAAALEN 1833 human
NP_005384 1884 PvgqKLQLACRLQQVAALVEN 1904 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap