2E5I


Conserved Protein Domain Family
RRM2_hnRPLL
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cd12786: RRM2_hnRPLL 
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RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
The subgroup corresponds to the RRM2 of hnRNP-LL which plays a critical and unique role in the signal-induced regulation of CD45 and acts as a global regulator of alternative splicing in activated T cells. It is closely related in domain structure and sequence to heterogeneous nuclear ribonucleoprotein L (hnRNP-L), which is an abundant nuclear, multifunctional RNA-binding protein with three RNA-recognition motifs (RRMs), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain).
Links
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Statistics
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PSSM-Id: 241230
Aligned: 5 rows
Threshold Bit Score: 199.084
Created: 14-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative RNA
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to Homo sapiens polypyrimidine tract binding protein.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # #                          # # #   # #                            #  ##  
2E5I_A        22 GNKVLLLSIQNplypiTVDVLYTVCNPVGkVQRIVIFKRNGIQAMVEFESvLCAQKAKAALNGADIYagCCTLKIEYARP 101 house mouse
NP_001133491 170 GNKVLLLSIQNplypiTTDVLYTVCNPIGsVMRIVIFKRNGIQAMVEFESiECAQKAKAALNGADIYagCCTLKIEYARP 249 Atlantic salmon
NP_001120904 154 GNKVLLLSIQNplypiTVDVLYSVCNPVGkVERIVIFKRNGIQAMVEFDSvHSAQKAKSSLNGADIYagCCTLKIEYARP 233 western clawed ...
NP_001292580 166 GNKVLLLSIQNplypiTVDVLYTVCNPVGkVQRIVIFKRNGIQAMVEFESvFCAQKAKAALNGADIYagCCTLKIEYARP 245 chicken
XP_006007837 166 GNKVLLLSIQNplypiTVDVLYNVCNPVGnVQRIVIFKRNGIQAMIEFNSvECAQKAKAALNGADIYagCCTLKIEYARP 245 coelacanth

Feature 1          #####         
2E5I_A       102 TRLNVIRNDNDSWDYT 117 house mouse
NP_001133491 250 TRLNVIRNDNESWDYT 265 Atlantic salmon
NP_001120904 234 TRLNVIRNDNDSWDYS 249 western clawed frog
NP_001292580 246 TQLNVIRNDNDSWDYT 261 chicken
XP_006007837 246 TRLNVIRNDNDSWDYT 261 coelacanth

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