Conserved Protein Domain Family
RRM2_ROD1
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cd12784: RRM2_ROD1 
RNA recognition motif 2 (RRM2) found in vertebrate regulator of differentiation 1 (Rod1)
This subgroup corresponds to the RRM2 of ROD1 coding protein Rod1, a mammalian polypyrimidine tract binding protein (PTB) homolog of a regulator of differentiation in the fission yeast Schizosaccharomyces pombe, where the nrd1 gene encodes an RNA binding protein and negatively regulates the onset of differentiation. ROD1 is predominantly expressed in hematopoietic cells or organs. It might play a role controlling differentiation in mammals. Rod1 contains four repeats of RNA recognition motifs (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain) and does have RNA binding activities.
Links
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Statistics
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PSSM-Id: 410176
Aligned: 6 rows
Threshold Bit Score: 215.253
Created: 14-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to Homo sapiens polypyrimidine tract binding protein.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # #                          # # #  # # #                            #  ##
O95758       177 GQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFS 256 human
NP_001120518 146 GQSPVLRIIVENLFYPVTLEVLHQIFSKFGTVIKIITFTKNNQFQALLQYADPMNAHHAKVALDGQNIYNACCTLRIEFS 225 western clawed ...
RXN21408     147 GQSPVLRIIVENLYYPVSLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPMNAHHAKVALDGQNIYNGCCTLRVEFS 226 rohu
KYO35147     146 GQSSVLRIVVENLFYPVTLEVLYQIFSKFGTVLKIITFTKNNQFQALLQYADPMNAHYAKMALDGQNIYNACCTLRIDFS 225 American alligator
XP_007904702 167 GQSPVLRIIVENLFYPVTLEVLHQIFTKYGTVLKIITFTKNNQFQALLQYADPMHAHHAKLALDGQNIYNACCTLRIEFS 246 elephant shark
XP_014342432 177 GQSPVLRIIVENLYYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYAEPMNAHHAKVALEGQNIYNACCTLRIEFS 256 coelacanth

Feature 1        ##  ##### ###               
O95758       257 KLTSLNVKYNNDKSRDFTRLDLPTGDGQ 284 human
NP_001120518 226 KLTSLNVKYNNDKSRDFTRLDLPTGDGQ 253 western clawed frog
RXN21408     227 KLTSLNVKYNNDKSRDFTRLDLPSGDGQ 254 rohu
KYO35147     226 KLTSLNVKYNNDKSRDFTRLDLPSGDGQ 253 American alligator
XP_007904702 247 KLTALNVKYNNDKSRDFTRLDLPSGDGQ 274 elephant shark
XP_014342432 257 KLTSLNVKYNNDKSRDFTRIDLPSGDGQ 284 coelacanth

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