2AD9,2N3O,1SJQ


Conserved Protein Domain Family
RRM1_PTBP1

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cd12777: RRM1_PTBP1 
Click on image for an interactive view with Cn3D
RNA recognition motif 1 (RRM1) found in vertebrate polypyrimidine tract-binding protein 1 (PTB)
This subgroup corresponds to the RRM1 of PTB, also known as 58 kDa RNA-binding protein PPTB-1 or heterogeneous nuclear ribonucleoprotein I (hnRNP I), an important negative regulator of alternative splicing in mammalian cells. PTB also functions at several other aspects of mRNA metabolism, including mRNA localization, stabilization, polyadenylation, and translation. PTB contains four RNA recognition motifs (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain). RRM1 and RRM2 are independent from each other and separated by flexible linkers. By contrast, there is an unusual and conserved interdomain interaction between RRM3 and RRM4. It is widely held that only RRMs 3 and 4 are involved in RNA binding and RRM2 mediates PTB homodimer formation. However, new evidence shows that the RRMs 1 and 2 also contribute substantially to RNA binding. Moreover, PTB may not always dimerize to repress splicing. It is a monomer in solution.
Statistics
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PSSM-Id: 410169
Aligned: 8 rows
Threshold Bit Score: 175.939
Created: 14-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2AD9; Homo sapiens polypyrimidine tract binding protein RNA recognition motif 1 binds a CUCUCU oligonucleotide, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           # ##                       # #  ### #                              #####  ###
2AD9_A        32 RVIHIRKLPiDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYtsvtPVLRGQPIYIQFSNHKELKT 111 human
NP_001026106  29 RVIHVRKLPsDVTEAEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYttvtPVLRSQPIYIQFSNHKELKT 108 chicken
NP_001080169  56 RVIHVRKLPgDVTEAEVISLGLPFGKVTNLLMLKGKNQAFLEMNTEEAANTIINYYsnvaPVLRGQPIYIQYSNHKELKT 135 African clawed ...
NP_001018313  74 RVIHVRKLPnDINEAEVISLGLPFGKVTNLLMLKGKNQAFLEMNTEESAQTMVSYYssvtPVIRNHPIFMQYSNHKELKT 153 zebrafish
2N3O_A        19 RVIHIRKLPiDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYtsvtPVLRGQPIYIQFSNHKELKT 98  human
1SJQ_A        17 RVIHIRKLPiDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYtsvtPVLRGQPIYIQFSNHKELKT 96  human
XP_007899192  72 KVIHIRKLPnDITEAEVISLGLPFGKVTNLLMLKGKNQAFIEMNSEEAANTMVSYYstvtPYLRNHPIYIQYSNHKELKT 151 elephant shark
XP_005991998  58 RVIHVRKLPnDITEAEVISLGLPFGKVTNLLMLKGKNQAFLEMSTEEAANTMMSYYttvtPVLRNQAIYVQFSNHRELKT 137 coelacanth
Feature 1         
2AD9_A       112 D 112 human
NP_001026106 109 D 109 chicken
NP_001080169 136 D 136 African clawed frog
NP_001018313 154 D 154 zebrafish
2N3O_A        99 D 99  human
1SJQ_A        97 D 97  human
XP_007899192 152 D 152 elephant shark
XP_005991998 138 D 138 coelacanth

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