1FXL


Conserved Protein Domain Family
RRM2_HuD
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cd12774: RRM2_HuD 
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RNA recognition motif 2 (RRM2) found in vertebrate Hu-antigen D (HuD)
This subgroup corresponds to the RRM2 of HuD, also termed ELAV-like protein 4 (ELAV-4), or paraneoplastic encephalomyelitis antigen HuD, one of the neuronal members of the Hu family. The neuronal Hu proteins play important roles in neuronal differentiation, plasticity and memory. HuD has been implicated in various aspects of neuronal function, such as the commitment and differentiation of neuronal precursors as well as synaptic remodeling in mature neurons. HuD also functions as an important regulator of mRNA expression in neurons by interacting with AU-rich RNA element (ARE) and stabilizing multiple transcripts. Moreover, HuD regulates the nuclear processing/stability of N-myc pre-mRNA in neuroblastoma cells and also regulates the neurite elongation and morphological differentiation. HuD specifically binds poly(A) RNA. Like other Hu proteins, HuD contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). RRM1 and RRM2 may cooperate in binding to an ARE. RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410167
Aligned: 7 rows
Threshold Bit Score: 164.896
Created: 15-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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RNA binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1FXL_A; Homo sapiens HuD protein in complex with AU-rich element, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # #                          #             #   # #                        
1FXL_A        84 ASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGV---SRGVGFIRFDKRIEAEEAIKGLNGQKPSGATE 160 human
Q7SZT7       161 ASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGV---SRGVGFIRFDKRIEAEEAIKGLNGQKPSGAAE 237 African clawed ...
NP_990161    132 ASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGV---SRGVGFIRFDKRIEAEEAIKGLNGQKPSGATE 208 chicken
NP_571528    161 ASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGPtggSRGVGFIRFDKRIEAEEAIKGLNGQKPSGAAE 240 zebrafish
XP_014350421 148 ASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGV---SRGVGFIRFDKRIEAEEAIKGLNGQKPSGATE 224 coelacanth
AAH99348     121 ASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGV---SRGVGFIRFDKRIEAEEAIKGLNGQKPSGAAE 197 African clawed ...
XP_007901849 127 ASIRDANLYVSGLPKSMTQKELEQMFSQYGRIITSRILVDQVTGV---SRGVGFIRFDKRIEAEEAIKGLNGQKPSSATE 203 elephant shark

Feature 1            # #
1FXL_A       161 PITVKFA 167 human
Q7SZT7       238 PITVKFA 244 African clawed frog
NP_990161    209 PITVKFA 215 chicken
NP_571528    241 PITVKFA 247 zebrafish
XP_014350421 225 PITVKFA 231 coelacanth
AAH99348     198 PITVKFA 204 African clawed frog
XP_007901849 204 PITVKFA 210 elephant shark

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