4ED5,4EGL


Conserved Protein Domain Family
RRM2_HuR

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cd12773: RRM2_HuR 
Click on image for an interactive view with Cn3D
RNA recognition motif 2 (RRM2) found in vertebrate Hu-antigen R (HuR)
This subgroup corresponds to the RRM2 of HuR, also termed ELAV-like protein 1 (ELAV-1), the ubiquitously expressed Hu family member. It has a variety of biological functions mostly related to the regulation of cellular response to DNA damage and other types of stress. HuR has an anti-apoptotic function during early cell stress response. It binds to mRNAs and enhances the expression of several anti-apoptotic proteins, such as p21waf1, p53, and prothymosin alpha. HuR also has pro-apoptotic function by promoting apoptosis when cell death is unavoidable. Furthermore, HuR may be important in muscle differentiation, adipogenesis, suppression of inflammatory response and modulation of gene expression in response to chronic ethanol exposure and amino acid starvation. Like other Hu proteins, HuR contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). RRM1 and RRM2 may cooperate in binding to an AU-rich RNA element (ARE). RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions.
Statistics
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PSSM-Id: 410166
Aligned: 7 rows
Threshold Bit Score: 174.329
Created: 15-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # #                       ## # #        #   # #                            # ##
4ED5_A        89 ANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQttGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAA 168 human
NP_990164    106 ANLYISGLPRSMTQKDVVDMFSRFGRIINSRVLVDQttGLSRGVAFIRFDKRSEAEEAITNFNGHKPPGSSEPITVKFAA 185 chicken
AAA96938      25 ANLYISGLPKTMTQKDVEEMFGRYGRIINSRVLVDQasGLSRGVAFIRFDKRAEAEDAIKDLNGQKPPGAAEQMTVKFAA 104 zebrafish
Q5U259       106 ANLYISGLPRTMTQKDVEDMFLPFGHIINSRVLVDQatGLSRGVAFIRFDKRSEAEEAIASFNGHKPPGSSEPITVKFAA 185 African clawed ...
4EGL_A        89 ANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQttGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVXFAA 168 human
XP_005989935 106 ANLYISGLPRTMTQKDVEDMFSHYGRIINSRVLVDQatGLSRGVAFIRFDKRGEAEDAIRNLNGHKPAGATEPVTVKFAA 185 coelacanth
XP_007899292 124 ANLYVSGLPKTMTQKDLEQLFGRYGRIITSRVLVDQvsGMSRGVAFIRFDRKSEADEAIKNLNGHKPPGAVEPITVKLAA 203 elephant shark
Feature 1            
4ED5_A       169 NLEH 172 human
NP_990164    186 NPNQ 189 chicken
AAA96938     105 SPNQ 108 zebrafish
Q5U259       186 NPNQ 189 African clawed frog
4EGL_A       169 NLEH 172 human
XP_005989935 186 NPNQ 189 coelacanth
XP_007899292 204 NPNQ 207 elephant shark

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