1FNX,1D8Z


Conserved Protein Domain Family
RRM1_HuC
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cd12772: RRM1_HuC 
Click on image for an interactive view with Cn3D
RNA recognition motif 1 (RRM1) found in vertebrate Hu-antigen C (HuC)
This subgroup corresponds to the RRM1 of HuC, also termed ELAV-like protein 3 (ELAV-3), or paraneoplastic cerebellar degeneration-associated antigen, or paraneoplastic limbic encephalitis antigen 21 (PLE21), one of the neuronal members of the Hu family. The neuronal Hu proteins play important roles in neuronal differentiation, plasticity and memory. Like other Hu proteins, HuC contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). RRM1 and RRM2 may cooperate in binding to an AU-rich RNA element (ARE). The AU-rich element binding of HuC can be inhibited by flavonoids. RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410165
Aligned: 5 rows
Threshold Bit Score: 164.906
Created: 15-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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RNA binding
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1FNX; Mus musculus HuC protein RMM1/2 in complex with the AU-rich element, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # # ##  #                    #### #   ##### #                       #### # 
1FNX_H         1 MDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSY 80  house mouse
NP_571524     34 DDSKTNLIVNYLPQNMTQEEFKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYVDPNDADKAINTLNGLKLQTKTIKVSY 113 zebrafish
Q91584        30 DDSKTNLIVNYLPQNMTQEEFKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYVDPNDADKAINTLNGLKLQTKTIKVSY 109 African clawed ...
XP_014375295  41 DDSKTNLIVNYLPQNMTQEEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYVDPNDADKAISTLNGLKLQTKTIKVSY 120 Chinese alligator
1D8Z_A         1 MDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSY 80  house mouse

Feature 1        ##   
1FNX_H        81 ARPSS 85  house mouse
NP_571524    114 ARPSS 118 zebrafish
Q91584       110 ARPSS 114 African clawed frog
XP_014375295 121 ARPSS 125 Chinese alligator
1D8Z_A        81 ARPSS 85  house mouse

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