Conserved Protein Domain Family
RRM1_HuB

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cd12771: RRM1_HuB 
RNA recognition motif 1 (RRM1) found in vertebrate Hu-antigen B (HuB)
This subgroup corresponds to the RRM1 of HuB, also termed ELAV-like protein 2 (ELAV-2), or ELAV-like neuronal protein 1, or nervous system-specific RNA-binding protein Hel-N1 (Hel-N1), one of the neuronal members of the Hu family. The neuronal Hu proteins play important roles in neuronal differentiation, plasticity and memory. HuB is also expressed in gonads and is up-regulated during neuronal differentiation of embryonic carcinoma P19 cells. Like other Hu proteins, HuB contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). RRM1 and RRM2 may cooperate in binding to an AU-rich RNA element (ARE). RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions.
Statistics
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PSSM-Id: 410164
Aligned: 4 rows
Threshold Bit Score: 170.677
Created: 1-Feb-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on similarity to the sequence of Homo sapiens HuR protein.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             # # ##  #                    # #       ### # #                       ## #  
Q12926        35 EDSKTNLIVNYLPQnMTQEELKSLFGSIGEIESCKLVRDKIT-GQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVS 113 human
Q91903        62 EDSKTNLIVNYLPQnMTQEELKSLFGSIGEIESCKLVRDKITeGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVS 141 African clawed ...
NP_001002172  64 EDSKTNLIVNYLPQnMTQEELKSLFGSIGEIESCKLVRDKIT-GQSLGYGFVNYMEPKDAEKAINTLNGLRLQTKTIKVS 142 zebrafish
KQK83885      63 EDSKTNLIVNYLPQnMTQEELKSLFGSIGEIESCKLVRDKIT-GQSLGYGFVNYVEPKDAEKAINTLNGLRLQTKTIKVS 141 blue-fronted am...
Feature 1         #  
Q12926       114 YARP 117 human
Q91903       142 YARP 145 African clawed frog
NP_001002172 143 YARP 146 zebrafish
KQK83885     142 YARP 145 blue-fronted amazon

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