Conserved Protein Domain Family
RRM1_hnRNPA3

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cd12763: RRM1_hnRNPA3 
RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
This subgroup corresponds to the RRM1 of hnRNP A3 which is a novel RNA trafficking response element-binding protein that interacts with the hnRNP A2 response element (A2RE) independently of hnRNP A2 and participates in the trafficking of A2RE-containing RNA. hnRNP A3 can shuttle between the nucleus and the cytoplasm. It contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), followed by a long glycine-rich region at the C-terminus.
Statistics
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PSSM-Id: 410156
Aligned: 6 rows
Threshold Bit Score: 158.292
Created: 20-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on similarity to the sequence of Homo sapiens hnRNP A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           # # ##                     # # #        ### #                      #  # #####
P51991        33 QLRKLFIGGLSfetTDDSLREHFEKWGTLTDCVVMRDpqtkrsRGFGFVTYSCVEEVDAAMCArpHKVDGRVVEPKRAVS 112 human
P51992        25 QLRKLFIGGLSfetTDDSLREHFEQWGKLTDCVVMRDpqtkrsRGFGFVTYSCVEEVDASMSArpHKVDGRVVEPKRAVS 104 African clawed ...
P51968        25 QLRKLFIGGLSfetTDDSLREHFEQWGKLTDCVVMRDpqtkrsRGFGFVTYSCVEEVDASMSArpHKVDGRVVEPKRAVS 104 African clawed ...
RLW01075       9 QLRKLFIGGLSfetTDDSLREHFEKWGTLTDCVVMRDpqtkrsRGFGFVTYSCVEEVDAAMSArpHKVDGRVVEPKRAVS 88  Gouldian finch
XP_014349355  11 QLRKLFIGGLSfetTDESLREHFEQWGTLTDCVVMRDpqtkrsRGFGFVTYSCVSEVDAAMAArpHKVDGRIVEPKRAVS 90  coelacanth
XP_007883080   6 QLRKLFIGGLSfetTDDSLRTHFEQWGRLTDCVVMRDpqtkrsRGFGFVTYSCVSEVDEAMSArpHKVDGRVVEPKRAVS 85  elephant shark
Feature 1        #
P51991       113 R 113 human
P51992       105 R 105 African clawed frog
P51968       105 R 105 African clawed frog
RLW01075      89 R 89  Gouldian finch
XP_014349355  91 R 91  coelacanth
XP_007883080  86 R 86  elephant shark

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