1HD0,5IM0,5IM0


Conserved Protein Domain Family
RRM1_hnRNPD

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cd12756: RRM1_hnRNPD 
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RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
This subgroup corresponds to the RRM1 of hnRNP D0, also termed AU-rich element RNA-binding protein 1, which is a UUAG-specific nuclear RNA binding protein that may be involved in pre-mRNA splicing and telomere elongation. hnRNP D0 contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), in the middle and an RGG box rich in glycine and arginine residues in the C-terminal part. Each of RRMs can bind solely to the UUAG sequence specifically.
Statistics
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PSSM-Id: 410150
Aligned: 8 rows
Threshold Bit Score: 130.887
Created: 20-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HD0_A         2 MFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRA 75  human
NP_001103930  56 MFVGGLSWDTTKKDLKDYFTKFGEVVDCTLKLDPLTGRSRGFGFVLFKEAESVEKVITQKEHKLNGKVIDPKKA 129 zebrafish
NP_001088992  40 MFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESEGVDKVMEQKEHKLNGKVIDPKRA 113 African clawed frog
NP_001026314   1 MFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRA 74  chicken
5IM0_B         5 XFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVXDQKEHKLNGKVIDPKRA 78  human
5IM0_A        11 XFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVXDQKEHKLNGKVIDPKRA 84  human
XP_007887160  77 MFVGGLSWDTTKKDLKDYFSKYGEVVDCTLKLDPITGRSRGFGFVLFKEAESVDKVMEMKEHKLNGKVIDPKRA 150 elephant shark
XP_006010156  53 MFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMELKEHKLNGKVIDPKRA 126 coelacanth
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