2LKZ


Conserved Protein Domain Family
RRM2_RBM5

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cd12755: RRM2_RBM5 
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RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)
This subgroup corresponds to the RRM2 of RBM5, also termed protein G15, or putative tumor suppressor LUCA15, or renal carcinoma antigen NY-REN-9, a known modulator of apoptosis. It may also act as a tumor suppressor or an RNA splicing factor. RBM5 shows high sequence similarity to RNA-binding protein 6 (RBM6 or NY-LU-12 or g16 or DEF-3). Both, RBM5 and RBM6, specifically bind poly(G) RNA. They contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two C2H2-type zinc fingers, a nuclear localization signal, and a G-patch/D111 domain.
Statistics
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PSSM-Id: 410149
Aligned: 7 rows
Threshold Bit Score: 153.929
Created: 17-Jan-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2LKZ_A         8 HMDTIILRNIAPhTVVDSIMTALSPYASLAvNNIRLIKDKQtQQNRGFAFVQLSsAMDASQLLQILqsLHPPLKIDGKTI 87  human
A0JMV4       239 VSSAIILRNIGPhTVVDSILSALAPYVSLVvSNIRLIKDKQtQQNRGFAFVQLPsALEASQLLQILqtLHPPLKIDGKTI 318 African clawed ...
NP_001012798 327 YCDTIILRNIAPhTVVESIMTALSPYASLAvNNIRLIKDKQtQQNRGFAFVQLSsAMDASQLLQILqsLQPPLKIDGKTI 406 chicken
Q6DDU9       239 VSSAIILRNIGPhTVVDSILSALAPYVSLVvSNIRLIKDKQtQQNRGFAFVQLPsALEASQLLQILqtLHPPLKIDGKTI 318 African clawed ...
P52756       229 YCDTIILRNIAPhTVVDSIMTALSPYASLAvNNIRLIKDKQtQQNRGFAFVQLSsAMDASQLLQILqsLHPPLKIDGKTI 308 human
XP_014344031 232 YSDTIILRNIAPhTSVEAIMTGLSPYAALSvGNIRLIKDKQtQQNRGFAFVQLSsALEASQLLQILqaLQPPLKIDGKTI 311 coelacanth
NP_001093608 246 YGDTIILRNIAPlSTVEAILGALAPFANLLpGNIRLIKDKQtGQNRGFAFVQLAsPLEASQLLTILqgLQPPLKLDGKTI 325 zebrafish
2LKZ_A        88 GVDFAK 93  human
A0JMV4       319 GVDFAK 324 African clawed frog
NP_001012798 407 GVDFAK 412 chicken
Q6DDU9       319 GVDFAK 324 African clawed frog
P52756       309 GVDFAK 314 human
XP_014344031 312 GVDFAK 317 coelacanth
NP_001093608 326 GVDYAK 331 zebrafish
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