2HGM,1WG5,2KG0,6DG1,6DHS


Conserved Protein Domain Family
RRM2_hnRNPH_hnRNPH2_hnRNPF

?
cd12731: RRM2_hnRNPH_hnRNPH2_hnRNPF 
Click on image for an interactive view with Cn3D
RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
This subgroup corresponds to the RRM2 of hnRNP H (also termed mcs94-1), hnRNP H2 (also termed FTP-3 or hnRNP H') and hnRNP F. These represent a group of nuclear RNA binding proteins that play important roles in the regulation of alternative splicing decisions. hnRNP H and hnRNP F are two closely related proteins, both of which bind to the RNA sequence DGGGD. They are present in a complex with the tissue-specific splicing factor Fox2, and regulate the alternative splicing of the fibroblast growth factor receptor 2 (FGFR2) transcripts. The presence of Fox 2 can allows hnRNP H and hnRNP F to better compete with the SR protein ASF/SF2 for binding to FGFR2 exon IIIc. Thus, hnRNP H and hnRNP F can function as potent silencers of FGFR2 exon IIIc inclusion through an interaction with the exonic GGG motifs. Furthermore, hnRNP H and hnRNP H2 are almost identical; both have been found to bind nuclear-matrix proteins. hnRNP H activates exon inclusion by binding G-rich intronic elements downstream of the 5' splice site in the transcripts of c-src, human immunodeficiency virus type 1 (HIV-1), Bcl-X, GRIN1, and myelin. It silences exons when bound to exonic elements in the transcripts of beta-tropomyosin, HIV-1, and alpha-tropomyosin. hnRNP H2 has been implicated in pre-mRNA 3' end formation. Members in this family contain three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). RRM1 and RRM2 are responsible for the binding to the RNA at DGGGD motifs, and they play an important role in efficiently silencing the exon. In addition, the family members have an extensive glycine-rich region near the C-terminus, which may allow them to homo- or heterodimerize.
Statistics
?
PSSM-Id: 410130
Aligned: 10 rows
Threshold Bit Score: 189.837
Created: 21-Sep-2011
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2HGM_A        35 NSADSANDGFVRLRGLPFGCTKEEIVQFFsGLEIVPNGITLPVDpeGKITGEAFVQFASQELAEKALGKHKERIGHRYIE 114 human
1WG5_A         8 NSPDTANDGFVRLRGLPFGCSKEEIVQFFsGLEIVPNGMTLPVDfqGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIE 87  human
P55795       103 NSPDTANDGFVRLRGLPFGCSKEEIVQFFsGLEIVPNGMTLPVDfqGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIE 182 human
NP_989827    153 NSPDTANDGFVRLRGLPFGCSKEEIVQFFsGLEIVPNGITLPVDfqGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIE 232 chicken
NP_991247     99 NCPETGGDGLVRLRGLPFGCSKEEIVQFFaGLEIVPNGITLPVDfqGRSTGEAFVQFASQDIAEKALKKHKERIGHRYIE 178 zebrafish
AAH74690     102 NSPDTANDGFVRLRGLPFGCSKEEIVQFFsGLEIVPNGITLPVDfqGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIE 181 western clawed ...
NP_001086923 102 NSPDTANDGFVRLRGLPFGCSKEEIVQFFsGLEIVPNGITLPVDfqGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIE 181 African clawed ...
2KG0_A        35 NSADSANDGFVRLRGLPFGCTKEEIVQFFsGLEIVPNGITLPVDpeGKITGEAFVQFASQELAEKALGKHKERIGHRYIE 114 human
6DG1_A        14 NSPDTANDGFVRLRGLPFGCSKEEIVQFFsGLEIVPNGITLPVDfqGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIE 93  human
6DHS_A        97 NSPDTANDGFVRLRGLPFGCSKEEIVQFFsGLEIVPNGITLPVDfqGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIE 176 human
2HGM_A       115 VFKSSQEEVR 124 human
1WG5_A        88 IFKSSRAEVR 97  human
P55795       183 IFKSSRAEVR 192 human
NP_989827    233 IFKSSRAEVR 242 chicken
NP_991247    179 IFKSSRAEVR 188 zebrafish
AAH74690     182 IFKSSRAEVR 191 western clawed frog
NP_001086923 182 IFKSSRAEVR 191 African clawed frog
2KG0_A       115 VFKSSQEEVR 124 human
6DG1_A        94 IFKSSRAEVR 103 human
6DHS_A       177 IFKSSRAEVR 186 human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap