2MKI


Conserved Protein Domain Family
RRM2_CPEB2_like

?
cd12726: RRM2_CPEB2_like 
Click on image for an interactive view with Cn3D
RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
This subgroup corresponds to the RRM2 of the paralog proteins CPEB-2, CPEB-3 and CPEB-4, all well conserved in both, vertebrates and invertebrates. Due to the high sequence similarity, members in this family may share similar expression patterns and functions. CPEB-2 is an RNA-binding protein that is abundantly expressed in testis and localized in cytoplasm in transfected HeLa cells. It preferentially binds to poly(U) RNA oligomers and may regulate the translation of stored mRNAs during spermiogenesis. Moreover, CPEB-2 impedes target RNA translation at elongation; it directly interacts with the elongation factor, eEF2, to reduce eEF2/ribosome-activated GTP hydrolysis in vitro and inhibit peptide elongation of CPEB2-bound RNA in vivo. CPEB-3 is a sequence-specific translational regulatory protein that regulates translation in a polyadenylation-independent manner. It functions as a translational repressor that governs the synthesis of the AMPA receptor GluR2 through binding GluR2 mRNA. It also represses translation of a reporter RNA in transfected neurons and stimulates translation in response to NMDA. CPEB-4 is an RNA-binding protein that mediates meiotic mRNA cytoplasmic polyadenylation and translation. It is essential for neuron survival and present on the endoplasmic reticulum (ER). It is accumulated in the nucleus upon ischemia or the depletion of ER calcium. CPEB-4 is overexpressed in a large variety of tumors and is associated with many mRNAs in cancer cells. All family members contain an N-terminal unstructured region, two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a Zn-finger motif. In addition, they do have conserved nuclear export signals that are not present in CPEB-1.
Statistics
?
PSSM-Id: 410125
Aligned: 30 rows
Threshold Bit Score: 141.409
Created: 21-Sep-2011
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2MKI_A        121 KTIFVGGVPrplrAVELAMIMdrlYGGVCYAGIDTDpELKYPKGAGRVAFSnqQSYIAAISARFVQLqhgeidKRVEVKP 200  human
CBY23134      369 KTIFVGGVPrplrAVELAIIMerlYGSVCYAGIDTDpELKYPKGAGRVAFSsqQSYIAAISARFVQLqygdidKRVEVKP 448  Oikopleura di...
Q03571        366 RTVFIGGVPrptrAQDLARCLeghYGKVSYVGIDIDpELKYPKGAARVTFStsQAFVRAISGRFVQVnhaennKRVEIKP 445  nematode
XP_003383311  259 KTIFIGGVPrplkAAELADIFnsrYGNVCYAGIDCDpDLKYPKGAGRVTFSsrVSFMSAVSCRFFQVtygdidKKVEVKP 338  Amphimedon qu...
XP_002114738  184 KTIFVGGVPrplrACELAKIMndfYGGVCYAGIDTDpELKYPKGAGRVAFSnqQSYIAAISARFVQLqhgdidKRVEVKP 263  Trichoplax ad...
EFX86208      152 KTVFVGGVPrplkAVELALIMdrlYGGVCYAGIDIDpELKYPKGAGRVAFSnqQSYIAAISARFVQLqhgdidKRVEVKP 231  common water ...
GAA28518      854 KTIFVGGVPrplrAIELALIMdrlYSGVCYAGIDTDpELKYPKGAGRVAFSnqQSYIAAISARFVQLqhneidKRVEVKP 933  Clonorchis si...
XP_001640766  122 KTIFVGGVPrplrAIELAMIMdrlYGGVCYAGIDVDpELKYPKGAGRVAFSnqQSYIAAISARFVQLqhgdidKRVEVKP 201  starlet sea a...
ELU07792      155 KTIFVGGVPrplrARELAMIMnqlYGGVCYAGIDTDpELKYPKGAGRVAFSnqQSYIAAISARFVQLqhgdidKRVEVKP 234  Capitella teleta
PIK49486      504 KTIFVGGVPrpmrAVELAVTMdrlYGGVCYAGIDTDpELKYPKGAGRVAFSnqQSYIAAISARFVQLkqgdidKRVEVKP 583  Japanese sea ...
2MKI_A        201 Y 201  human
CBY23134      449 Y 449  Oikopleura dioica
Q03571        446 Y 446  nematode
XP_003383311  339 Y 339  Amphimedon queenslandica
XP_002114738  264 Y 264  Trichoplax adhaerens
EFX86208      232 Y 232  common water flea
GAA28518      934 Y 934  Clonorchis sinensis
XP_001640766  202 Y 202  starlet sea anemone
ELU07792      235 Y 235  Capitella teleta
PIK49486      584 Y 584  Japanese sea cucumber
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap