2MKK,2MKH


Conserved Protein Domain Family
RRM1_CPEB1

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cd12723: RRM1_CPEB1 
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RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
This subgroup corresponds to the RRM2 of CPEB-1 (also termed CPE-BP1 or CEBP), an RNA-binding protein that interacts with the cytoplasmic polyadenylation element (CPE), a short U-rich motif in the 3' untranslated regions (UTRs) of certain mRNAs. It functions as a translational regulator that plays a major role in the control of maternal CPE-containing mRNA in oocytes, as well as of subsynaptic CPE-containing mRNA in neurons. Once phosphorylated and recruiting the polyadenylation complex, CPEB-1 may function as a translational activator stimulating polyadenylation and translation. Otherwise, it may function as a translational inhibitor when dephosphorylated and bound to a protein such as maskin or neuroguidin, which blocks translation initiation through interfering with the assembly of eIF-4E and eIF-4G. Although CPEB-1 is mainly located in cytoplasm, it can shuttle between nucleus and cytoplasm. CPEB-1 contains an N-terminal unstructured region, two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a Zn-finger motif. Both of the RRMs and the Zn finger are required for CPEB-1 to bind CPE. The N-terminal regulatory region may be responsible for CPEB-1 interacting with other proteins.
Statistics
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PSSM-Id: 410122
Aligned: 23 rows
Threshold Bit Score: 158.236
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2MKK_A        17 YSCKVFLGGVPWDITEAGLVNTFRvFGSLSVEWPGKDgkhpr--cppkGYVYLVFELEKSVRSLLQACshdplspdglse 94  human
EFX72448      34 YSCKVFLGGVPWDITEVSLTNAFKqFGSIKVEWPGKDnvan----ppkGYVYIIFDNEKHVKSLLQACthdys---nggs 106 common water flea
XP_002127649 372 YSPKVFVGGVPWDITEAALHMTFKpYGLVRVEWPGKDmkgpr-yplraGYVYLLFESDKSIKSLLLNCthdv----ttne 446 Ciona intestinalis
XP_003388697 225 YSPRVFLGGVPWDTTEATLLALFQpFGNLSVDWPGKEnkhnr--hppkGYVYLTFEMEKSVKALLMTCgqnps---nagq 299 Amphimedon quee...
NP_732850    218 YSPKVFLGGIPWDISEQSLIQIFKpFGSIKVEWPGKEqqaa----qpkGYVYIIFESDKQVKALLSACvlqvddshcgrn 293 fruit fly
XP_002116321  31 YSVKVFIGGVPWDITEVELLASFGtYGNVTVEWPGKDcdhsk--hppkGYVYLIFNSSESVKKLLQNCsrs------ddk 102 Trichoplax adha...
XP_019644852 444 YSPKVFLGGVPWDITEVGLQAAFKpFGPIKVEWPGKDnkhpr-yppkaGYVYVLFESDKAVKALLQACthdfs---hgge 519 Belcher's lancelet
ELT91350      58 YSCKVFLGGVPWDITESGLQYAFRtFGAMKIEWPGKEgkhpr-yppkaGYVYVLFESDKSVKSLLQACthdfs---ngge 133 Capitella teleta
PFX22355     243 YSTKVFLGGVPWDITEASLVMSFKpFGSVKVEWPGKAdgrhl-hhppkGYVYLIFDSEKSVKALLASCthdfc---nggd 318 Stylophora pist...
PAA91457     439 FSRKVFLGGVPWDVSDLDLQQAFLrFGTLQVLWPAREasnvqirssprGYCYLIFDQELSVRNLLKQCtrdat---nige 515 Macrostomum lig...
2MKK_A        95 YYFKMSSRRmRCKEVQVIPWVLADS 119 human
EFX72448     107 WYYKISSRRmRSKEVQVIPWMLSDS 131 common water flea
XP_002127649 447 CFFRLSSRRmRSKEVQIIPWVVSDS 471 Ciona intestinalis
XP_003388697 300 YFCKVSSRRiRNKEVQVIPWALSDS 324 Amphimedon queenslandica
NP_732850    294 YFFKISSRRiKSKDVEVIPWIIADS 318 fruit fly
XP_002116321 103 YYQLVSSRQrKSKEVQVIPWALNDS 127 Trichoplax adhaerens
XP_019644852 520 YFYKISSRRmRCKEVQIIPWVTSDS 544 Belcher's lancelet
ELT91350     134 YYYKVSSRRmRSKEVQVIPWVMGDS 158 Capitella teleta
PFX22355     319 WYFKISSRRmRCKEVQVIPWVLSDT 343 Stylophora pistillata
PAA91457     516 YYFKISSSKmKAKEVQVIPWCINDS 540 Macrostomum lignano
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