Conserved Protein Domain Family
RRM_BRAP2

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cd12718: RRM_BRAP2 
RNA recognition motif (RRM) found in BRCA1-associated protein (BRAP2)
This subgroup corresponds to the RRM of BRAP2, also termed impedes mitogenic signal propagation (IMP), or ring finger protein 52, or renal carcinoma antigen NY-REN-63, a novel cytoplasmic protein interacting with the two functional nuclear localisation signal (NLS) motifs of BRCA1, a nuclear protein linked to breast cancer. It also binds to the SV40 large T antigen NLS motif and the bipartite NLS motif found in mitosin. BRAP2 may serve as a cytoplasmic retention protein and play a role in the regulation of nuclear protein transport. It contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), followed by a C3HC4-type ring finger domain and a UBP-type zinc finger.
Statistics
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PSSM-Id: 410117
Aligned: 20 rows
Threshold Bit Score: 139.317
Created: 15-May-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7Z569       160 SAMLCILTVPAaMTSHDLMKFVAPfnevIEQMKIIRDstPNQYMVLIKFRaqaDADSFYMtCNGRQFNSIEDDv-CQLVY 238 human
Q9VDZ1       147 SNQLCLLAVPAtLNCHDLLNFIAPchaeIKHIQIVRDgsPNQFMVLLEFRsneSALEFYKsYNGSTYNSLEPDslCHAVW 226 fruit fly
EFX84242     106 SQMICMLAIPAwLSCHDLLNFLAPccpgIRRVRIIRDktPNQYMALVLFRsqeEADECYKtFNGTPYNSIESEh-CHIVY 184 common water flea
XP_002115256  39 SEMLCMLAVPAtMSCNDLIQFAAPyspnIEHIKIIRDstPNEYMVLIKFKdqtCSDEFFKlYNGRTYHSLEDKi-CHLVY 117 Trichoplax adha...
XP_002605621 101 SEMICILNTPCsMLTCDLLKFMSPvrdrVEYMRIIRGsqPNHYMVLLKFHcqeYADEFYKnYNGMNYSSLEESv-CHLIY 179 Florida lancelet
GAA55637      64 STMLCIFSVPSyLTVKDLLSFLAPmrdsVEELKVVKNggPNHYMALLKFRseqETDQFYRtYNNTCYRNLESEv-CQLMY 142 Clonorchis sine...
CBY19618      86 SDMLLLVHVPVdLDTHDLLRFLGNydqkLEYIKIVRDqtLHQYMVLLKFDgqtSADTFYHsINGQKFNSLLEEt-CQVAY 164 Oikopleura dioica
PIK60048     201 SEMLCMLAVPAsMTCHSLLQFLAPcgegLLYVRIIRNntPNEFMVLLKFVdqrAADEVYKeFNNQPFNSFEDSc-CHLVF 279 Japanese sea cu...
ELU05344     165 SEMICILKVPAsIMSQDLIQFLAPvqsgLEIIRIIRDstPSQYMVLLKFVnqvAADEFYKnFNNKSFNSIEEDi-CYLVY 243 Capitella teleta
XP_012555942  63 SDTICMLGVPAkYSCQDLQNFIAPtgetVRHIQIIRDgnANQYMVLIRFKdqeSSDAFYReYEGKAYNMLEDEc-THLMF 141 Hydra vulgaris
Q7Z569       239 VERAE 243 human
Q9VDZ1       227 VSEVE 231 fruit fly
EFX84242     185 VAKVD 189 common water flea
XP_002115256 118 VSLVE 122 Trichoplax adhaerens
XP_002605621 180 VARVE 184 Florida lancelet
GAA55637     143 VSHVD 147 Clonorchis sinensis
CBY19618     165 VGKVE 169 Oikopleura dioica
PIK60048     280 ISRVE 284 Japanese sea cucumber
ELU05344     244 VARLE 248 Capitella teleta
XP_012555942 142 VSKVE 146 Hydra vulgaris
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