1X4F


Conserved Protein Domain Family
RRM2_MATR3

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cd12715: RRM2_MATR3 
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RNA recognition motif 2 (RRM2) found in vertebrate matrin-3
This subgroup corresponds to the RRM2 of Matrin 3 (MATR3 or P130), a highly conserved inner nuclear matrix protein with a bipartite nuclear localization signal (NLS), two zinc finger domains predicted to bind DNA, and two RNA recognition motifs (RRM), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), that are known to interact with RNA. MATR3 has been implicated in various biological processes. It is involved in RNA processing by interacting with other nuclear proteins to anchor hyperedited RNAs to the nuclear matrix. It plays a role in mRNA stabilization through maintaining the stability of certain mRNA species. Besides, it modulates the activity of proximal promoters by binding to highly repetitive sequences of matrix/scaffold attachment region (MAR/SAR). The phosphorylation of MATR3 is assumed to cause neuronal death. It is phosphorylated by the protein kinase ATM, which activates the cellular response to double strand breaks in the DNA. Its phosphorylation by protein kinase A (PKA) is responsible for the activation of the N-methyl-d-aspartic acid (NMDA) receptor. Furthermore, MATR3 has been identified as both a Ca2+-dependent CaM-binding protein and a downstream substrate of caspases. Additional research indicates that matrin 3 also binds Rev/Rev responsive element (RRE)-containing viral RNA and functions as a cofactor that mediates the post-transcriptional regulation of HIV-1.
Statistics
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PSSM-Id: 410114
Aligned: 7 rows
Threshold Bit Score: 153.451
Created: 27-Sep-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1X4F_A        26 RVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRmKSQAFIEMETREDAMAMVDHCLkkaLWFQGRCVKVDLSEKYKKL 105  house mouse
12643409     496 RVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRmKSQAFIEMETREDAMAMVDHCLkkaLWFQGRCVKVDLSEKYKKL 575  human
NP_989478    487 RVIHLSNLPHSGYSDNAVLKLAEPYGKIKNYILMRmKSQAFIEMETREDALAMVEHCAnkaLWFQGRCVKVDLSEKYKKL 566  chicken
Q6DFS8       439 RVVHLSNLPHSGYSDSAVIKLAEAYGKVKTYILMRkKNQAFIEMENKEDVQTMIDMCEknpLWFQGKHLKVDLSGKYKRL 518  western clawed...
XP_006003754 490 RVIHLSNLPFSGYTENSVLKLAEPYGKVKNYIFMKmKCQAFLEMESRADALAMVDHCRkksLWFQGRSLNVDLSDKYRTL 569  coelacanth
XP_007889545 574 RVVHISNLPSVGYSDAEIVSLGMPFGRVTNYLLMRvKNQVFLEMESHQAGMTMVEKFKkmpLLFHGRELKVYLSQKYKNL 653  elephant shark
XP_007889543 478 RVALFQNLPPSGYSDADVVKMGAGFGKVLNYIIMRlRNQAFLEMESKKALMDMVKHYKktpLIFRGRKVTVDASQKYKTL 557  elephant shark
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