Conserved Protein Domain Family
RRM_RCAN3

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cd12710: RRM_RCAN3 
RNA recognition motif (RRM) found in vertebrate regulator of calcineurin 3 (RCAN3)
This subgroup corresponds to the RRM of RCAN3, also termed calcipressin-3, or Down syndrome candidate region 1-like protein 2 (DSCR1L2), or myocyte-enriched calcineurin-interacting protein 3 (MCIP3), encoded by a ubiquitously expressed DSCR1L2 gene. Overexpressed RCAN3 binds and inhibits the Ca2+/calmodulin-dependent phosphatase calcineurin (also termed PP2B or PP3C), and further down-regulates nuclear factor of activated T cells (NFAT)-dependent cytokine gene expression in activated human Jurkat T cells. Moreover, RCAN3 interacts with cardiac troponin I (TNNI3), a heart-specific inhibitory subunit of the troponin complex, and may play a role in cardiac contraction. RCAN3 consists of an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and an unrecognized C-terminal TxxP motif of unknown function.
Statistics
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PSSM-Id: 410109
Aligned: 6 rows
Threshold Bit Score: 162.8
Created: 29-Feb-2012
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9UKA8        47 TSLFACSVHEAVfeareqKERFEALFTiYDDQVTFQLFKSFRRVRINFSKPeAAARARIELHETDFnGQKLKLYFAQ 123 human
NP_001005392  46 TALFACSVHEAVfeddryRERFEALFRiYDDQTSFQMFKSFRRVRISFSTPeAAARARIELHESDFnGTKLKLYFAQ 122 zebrafish
NP_001096163  49 TSLFACSVHDSVfeveeqKERFTALFRiYDEQVSFQMFKSFRRVRINFSNPeAAARARIELHESDFnGKKLKLYFAQ 125 western clawed frog
Q5ZJV6        47 TSLFACSVHEAVfevqeeKERFEALFTvYDNQVTFQLFKSFRRVRINFSNPeAAARARIELHETDFsGKKLKLYFAQ 123 chicken
XP_005988819  48 TALFACSVHDAVfeeelqRERFEALFQiYDGHVTFQLFKSFRRVRINFSNPeAAARARIELHESDFnGKKLKLYFAQ 124 coelacanth
XP_007902429  46 TALFACSVLEAVfedqehRDRFEALFRvYDNQATFQLFRSFRRIRINFSNPeAATRARIELHESDFsGSKLKLYFAQ 122 elephant shark
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