Conserved Protein Domain Family
RRM3_ROD1
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cd12697: RRM3_ROD1 
RNA recognition motif 3 (RRM3) found in vertebrate regulator of differentiation 1 (Rod1)
This subgroup corresponds to the RRM3 of ROD1 coding protein Rod1, a mammalian polypyrimidine tract binding protein (PTB) homolog of a regulator of differentiation in the fission yeast Schizosaccharomyces pombe, where the nrd1 gene encodes an RNA binding protein negatively regulates the onset of differentiation. ROD1 is predominantly expressed in hematopoietic cells or organs. It might play a role controlling differentiation in mammals. Rod1 contains four repeats of RNA recognition motifs (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain) and does have RNA binding activities.
Links
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Statistics
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PSSM-Id: 410097
Aligned: 3 rows
Threshold Bit Score: 156.284
Created: 14-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to Homo sapiens polypyrimidine tract binding protein.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           # ##                        # #     # #                          # # ### 
O95758       358 SVLLVTNLNPdlITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQ 433 human
NP_001120518 325 SVLLVSNLNPdaILPHGLFILFGVYGDVQRVKILFNKKENALVQMTDATQAQFAMSHLNGQRLHGRVLRITLSKHQ 400 western clawed frog
XP_424912    358 SVLLVSNLNPeaITPHGLFILFGAYGDVLRVKIMFKNKENALVQMADATQAQIAISNLNGQKLYGKFIRATLSKHQ 433 chicken

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