Conserved Protein Domain Family
RRM1_PTBPH1_PTBPH2
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cd12686: RRM1_PTBPH1_PTBPH2 
RNA recognition motif 1 (RRM1) found in plant polypyrimidine tract-binding protein homolog 1 and 2 (PTBPH1 and PTBPH2)
This subfamily corresponds to the RRM1 of PTBPH1 and PTBPH2. Although their biological roles remain unclear, PTBPH1 and PTBPH2 show significant sequence similarity to polypyrimidine tract binding protein (PTB) that is an important negative regulator of alternative splicing in mammalian cells and also functions at several other aspects of mRNA metabolism, including mRNA localization, stabilization, polyadenylation, and translation. Both, PTBPH1 and PTBPH2, contain three RNA recognition motifs (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain).
Links
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Statistics
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PSSM-Id: 410087
Aligned: 10 rows
Threshold Bit Score: 140.714
Created: 22-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to Homo sapiens polypyrimidine tract binding protein.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # ##                       # #     ### #                                   
Q9MAC5        15 PSKVVHLRNLPWECVEEELIDLCKRFGKIVNTKSNVGa-NRNQAFVEFADL----------------------------- 64  thale cress
Q9FGL9        16 PSKVLHLRNLPWECTEEELIELGKPFGTVVNTKCNVGa-NRNQAFIEFEDL----------------------------- 65  thale cress
ABK24339      16 PSKVLHLRNLPWECTEEELIELCKPFGRIVNTKCNVGa-NHNQAFVEFADL----------------------------- 65  Sitka spruce
EFJ11787      16 PSKVLHIRNLPWECTEEELIELCKMFGKVVNTKCNVGt-NRNQAFVEFADL----------------------------- 65  Selaginella moe...
EIE19256      13 PSKVLHIRNLPYETTEEELRELCSNFGPIVQTKLNVGt-NKNQAFVEFPDM----------------------------- 62  Coccomyxa sp. C...
XP_019577498  16 PSKVLHLRNLPWECTEDELIELGKPFGTVVNTKCNVGa-NRNQAFIEFEDL----------------------------- 65  Chinese rufous ...
PNR27394      16 PSKVLHVRNLPWECSEEELIELCKPFGKVVNTKVNVGa-NHNQAFVEFADL----------------------------- 65  Physcomitrella ...
XP_013897669  14 PSKVLHVRNLPPEAKEADVLGLCRPFGRMVRIKLTGAgtIKNQAFVEFVDM----------------------------- 64  Monoraphidium n...
PRW58890      16 PTKVIHFRNLPFDLTIEEIREFCAPWGTVVAVKEKVGa-NKNQCFVEFASI----------------------------- 65  Chlorella sorok...
KYP64649      15 PSKVLHLRNLPWECSEDELRDLCKPFGKIVNTKCNVGa-NRNQAFVEFGFQfrsglliggtrsivagveftpcatmavqi 93  pigeon pea

Feature 1                                                                        #####
Q9MAC5        65 --------------------------------------NQAISMVSYYASSSEPAQIRGKTVYIQYSNR 95  thale cress
Q9FGL9        66 --------------------------------------NQAIQMISYYASSSEPAQVRGKTVYLQYSNR 96  thale cress
ABK24339      66 --------------------------------------NQAIAMVSYYASSSEPAQVRGKSVYLQYSNR 96  Sitka spruce
EFJ11787      66 --------------------------------------NQAIAMVSFYASSSEPAQVRGKTVYLQYSNR 96  Selaginella moellendorffii
EIE19256      63 --------------------------------------NMAIQMVSYFANAADPAKVRGKTVYLQYSTR 93  Coccomyxa sp. C-169
XP_019577498  66 --------------------------------------NQAIQMISYYASSSEPAQVRGKTVYLQYSNR 96  Chinese rufous horseshoe bat
PNR27394      66 --------------------------------------NQAIAMVSYYASSSEPAQVRGKTVYLQYSNR 96  Physcomitrella patens
XP_013897669  65 --------------------------------------RSAIHMISYFVGNADPPRVCQKTVYLQYSTR 95  Monoraphidium neglectum
PRW58890      66 --------------------------------------DQALSIVNHYASSANPASFRGRPTWLSYSGR 96  Chlorella sorokiniana
KYP64649      94 cyelkkpsrkvvsasgltlvfinqglefnpylgqmadlNQAISMVSYYASSSEPAMVRGKTVYIQYSNR 162 pigeon pea

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