Conserved Protein Domain Family
RRM4_Nop4p
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cd12677: RRM4_Nop4p 
RNA recognition motif 4 (RRM4) found in yeast nucleolar protein 4 (Nop4p) and similar proteins
This subgroup corresponds to the RRM4 of Nop4p (also known as Nop77p), encoded by YPL043W from Saccharomyces cerevisiae. It is an essential nucleolar protein involved in processing and maturation of 27S pre-rRNA and biogenesis of 60S ribosomal subunits. Nop4p has four RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).
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Statistics
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PSSM-Id: 410078
Aligned: 6 rows
Threshold Bit Score: 190.841
Created: 7-Feb-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P37838       458 HLSMTRLAIRNLPRaMNDKALKALARKAVVeFATEVKNKERHPLSKEEiirstkekykfmgp--deieaqkkkdkksGVV 535 Saccharomyces c...
O74400       458 HLSLNRLSIRNISRhIDPKILAMLGRQAIRgFMDDVSKGLRANITEEEenldkghr--------------lkrgksgGVL 523 Schizosaccharom...
EHA20356     490 HLSLTRLSIRNIPRhVTTKDLKQLARQAIAgFAEDAKKGLRQPLSKEElnraadimre---------aeqlrkkkgvGVV 560 Aspergillus nig...
XP_023897287 491 HMSLTRLSIRNIPRsVGSKELKALAREAIVgFATEVKGGKRHRLSKEElarggdemva---------aeaarkkagkGVV 561 Quercus suber
CCJ30685     145 YISLTRLAVRNIPKdISDKDLKALARKACVdFAKEVKEKKRAPLTREEnlrdgn-----------------pkkgkkGIV 207 Pneumocystis ji...
KXN82917     530 YISRTRLSIRQIPIfVTERVLKRLALHAVRaFEAEVKEGRRNGLTDDEladppqvndevgnehpvskkkqkqlggrsTGV 609 Leucoagaricus s...

P37838       536 KQAKVIMEVKgs-------taGRSRGYGFVEFRdHKNALMGLRWLNCHAVTSDeileglnddek---------------- 592 Saccharomyces c...
O74400       524 KQAKVETEKAg---------aGRSKGFGFMQFIsHKYALMALRWLNGREITVKkiidaeiewarkhki------------ 582 Schizosaccharom...
EHA20356     561 RQAKIVFETRdghkvgedkaaGRSRGYGFIEYYtHRHALMALRWLNGHAVEAPatgsed--------------------- 619 Aspergillus nig...
XP_023897287 562 RQAKVVFEGAggskvseetgaGRSRGYGFIEYYtHRSALMGLRWLNGHAVGYQvknneaskktkp--------------- 626 Quercus suber
CCJ30685     208 RQAKILQEKN-----------GQARGCGFIEYVgHRWALMGLRWLNGRKISSKkne------------------------ 252 Pneumocystis ji...
KXN82917     610 RQAKIIRQRErvda---itgkGRSKGYGFIEMHkHSDALRVLRWANCNAGIGPlfeewykeemedllkiektkgeerdda 686 Leucoagaricus s...

P37838       593 --------kqvdndlgkgRRLCVEFAIENSNVVKRR 620 Saccharomyces cerevisiae S288c
O74400       583 ----pepqlpnidyndrpRRLIVEFAIENIQVVKRR 614 Schizosaccharomyces pombe 972h-
EHA20356     620 -------------akdkkKRLIVEFAIENAQVVKRR 642 Aspergillus niger ATCC 1015
XP_023897287 627 -------sigkdemqdrkKRLIVEFAIENAQVVQRR 655 Quercus suber
CCJ30685     253 ---------------nvkKRLIVEFALENINVVNRR 273 Pneumocystis jirovecii
KXN82917     687 kikrmreeiengpgkkggKTLIVEFSIENVQVVQRR 722 Leucoagaricus sp. SymC.cos
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